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Primary graft dysfunction (PGD), defined as ventricular dysfunction occurring within 24 hours after heart transplantation (HTx) in the absence of identifiable secondary causes, remains a major contributor to early post-transplant mortality. Over the past decade, there has been a growing understanding of the burden of PGD, the clinical relevance of PGD classification and severity grading, and effor

Surface strain rates around the southeastern dome of Hans Tausen Iskappe in Peary Land, North Greenland (82.5° N, 27.5° W), are determined from global positioning system surveys of a strain net. Average longitudinal surface strain rate increases towards the dome, from (1.4 ± 0.2) × 10−4 a−1 at 5–10 ice thicknesses from the divide to (2.4 ± 1.0) × 10−4 a−1 within 1 ice thickness from the divide. An

A snowmobile towed impulse radar measurement was used to produce detailed maps of ice-thickness in two areas, one on a local dome (the Hans Tausen ice cap), and one on an outlet glacier north thereof. A constant spatial sampling was achieved by using a device attached to the snowmobile's odometer. The bedrock reflection was automatically detected in the majority of the data, by using digital signa

The expansive carbon reservoirs of the boreal region are becoming some of the most rapidly growing sources of greenhouse gasses under a positive feedback between intensifying fire activity and climate change. However, current regional-scale methods lack the spatial precision needed to improve understanding of the drivers of these fluxes to inform strategies aimed at maximizing landscape carbon sto

This introductory paper outlines the conceptual foundations and research agenda for our special issue Contextual Complexities of Violence on Digital Platforms. We argue that violence on digital platforms cannot be understood as a fixed or self-evident category, but must be situated within the sociotechnical, cultural and political environments that shape its production, circulation and recognition

Part of the online anthology of the artistic research project Costume Dramaturgies – The Dramaturgy of Things in Performance. The project explores the dramaturgy of things – as costume – in performance, where dramaturgy is understood as an assembly of human and nonhuman “things.”

Disruptions in gut microbiome are implicated in cardiometabolic disorders and other health outcomes. Antibiotics are known gut microbiome disruptors, but their long-term consequences remain underexplored. Here we combined individual-level data from the Swedish Prescribed Drug Register with fecal metagenomes of 14,979 adults to examine the association between oral antibiotic use over 8 years and gu

In Charlotte Østergaard’s artistic research practice, co-creation is not merely a matter of establishing horizontal forms of collaboration between people. It is an investigation of how people, textile materials and local atmospheres mutually influence and respond to each other. Here, Charlotte Østergaard provides an insight into her current research and practice.

Klebsiella pneumoniae is a major opportunistic pathogen, where the polysaccharide capsule is traditionally recognized as a critical virulence determinant. However, its role in surface interactions and intracellular adaptation remains incompletely understood. Here, we combined phenotypic assays with physicochemical analyses to dissect the contribution of the capsule. A wza knockout mutant displ

Recension av Anders Edling och Erik Wallrup, red., Emil Sjögren – en vägvisare, 2022. Möklinta: Gidlunds förlag. 252 s. ISBN 978-91-7844-502-8.

Somatostatin, produced by pancreatic islet δ cells, is a key intra-islet paracrine factor that regulates the secretion of the glucoregulatory hormones insulin and glucagon from β cells and α cells, respectively. Here, we show that glutamate and glucagon released by α cells cooperatively activate neighbouring δ cells through AMPA and glucagon receptors, thereby enabling spatiotemporal feedback cont

The physical placement of antennas is a design factor for Distributed Multiple-Input Multiple-Output (D-MIMO) systems, but finding the optimal layout is a computationally intensive, non-convex problem. Prior research often addresses this by directly optimizing the coordinates of each distributed panels using complex numerical techniques, such as convex relaxation or iterative algorithms. While via

Aims: In a co-twin control design, we aimed to examine whether individuals who initiate metformin treatment have an altered risk of incident diagnosis of osteoarthritis (OA), for up to 11 years after starting the treatment, compared with their non-treated co-twin. Methods: In all twin pairs different for metformin treatment (N=1 261 pairs) and all eligible twins/singletons (N=52 341) aged 35–75 ye

Introduction: Despite therapeutic achievements in haemophilia care, there is still the need to monitor and define personal treatment outcomes and document results to achieve the best possible care. Hence, a need for unbiased, timely and comprehensive real-world information exists to support informed shared decision-making regarding treatment and care. Aim: To describe a medical device for people l

Introduction: Vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) is a technique combining vaginal entrance to the abdomen with endoscopic overview. Previous studies have shown that vNOTES decreases operating time, hospitalization, postoperative complications, and pain. We aimed to present patient demographics, costs, and surgical outcomes following the implementation of vNOTES for be

This paper investigates the construction of trust in scientific inquiries and defends the importance of social epistemology in 13th century Parisian astronomy. A major issue in ancient and medieval astronomy is attributed to the difficulty of acquiring precise first-hand knowledge of astral phenomena, making collective work necessary, but raising concerns about trusting second-hand knowledge. The