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Relapse of acute myeloid leukemia (AML) remains a significant clinical challenge due to limited therapeutic options and poor prognosis. Leukemic stem cells (LSCs) are the cellular units responsible for relapse in AML, and strategies that target LSCs are thus critical. One proposed potential strategy to this end is to break the quiescent state of LSCs, thereby sensitizing LSCs to conventional cytos
Photoionization time delays are measured with two-color (XUV+IR) interferometric techniques. The combination of attosecond temporal resolution and high spectral resolution from narrowband harmonics allows the study of ultrafast dynamics in both time and frequency domain.
Due to increased urbanisation, and climate change, there have been calls for a more sustainable management of stormwater. Blue-green measures have been recognised as a sustainable solution and a necessary complement to pipe-bound approaches. The aim of this study is to identify barriers and drivers in the implementation of blue-green measures in a Swedish context, to increase the understanding of
A literary manifesto is not a program. Even so, many are irritated by the doctrinal constraints of any manifesto or by its imprecision. There is confusion between the theoretical reinforcement of the manifesto, which has rather a conative function (to use a term in linguistics), of conviction. Predictive and limitative is the program. Politically speaking, the former proves "creative political ind
This article investigates how donation behavior to charitable organizations and helping intentions toward begging European Union (EU)-migrants are related. This question was tested by analyzing survey responses from 1,050 participants sampled from the general Swedish population. Although the overall results suggested that donations to charitable organizations were positively related to helping int
Statistical techniques exist for inferring community assembly processes from community patterns. Habitat filtering, competition, and biogeographical effects have, for example, been inferred from signals in phenotypic and phylogenetic data. The usefulness of current inference techniques is, however, debated as a mechanistic and causal link between process and pattern is often lacking, and evolution
Rapport över utredning i Sydvästra Lund. Utredningen berörde perioderna neolitikum till tidigmoderntid och utgör en ledtråd till att förstå uppkomsten och placering av Lund.
Since economic reforms were introduced in the late 1970s, China has undergone significant political, economic, and social transformations. The Chinese Communist Party (CCP)- led government has encountered massive student-led protests, outlasted both Eastern European and Soviet variants of communism, and weathered ethnic riots. Despite numerous predictions of its impending demise and anticipation o
Christianity has not only provided theological justification and imaginary to globalization processes but is also, in itself, a globalizing movement. Within Christianity, one can trace several types of globalizations; in this article, its global character with its huge variations is studied in light of globalization considered by contemporary scholarship under the labels “grobalization”, “grocaliz
Gene fusion transcripts containing PRDM10 were recently identified in low-grade undifferentiated pleomorphic sarcomas (UPS). Here, we describe the morphologic and clinical features of 9 such tumors from 5 men and 4 women (age: 20 to 61 y). Three cases had previously been diagnosed as UPS, 3 as superficial CD34-positive fibroblastic tumor (SCD34FT), 2 as pleomorphic liposarcoma, and 1 as pleomorphi
Two signals are required for induction of cell proliferation and cytokine production in resting T cells. Occupancy of the T cell receptor by antigen/MHC complexes delivers the first signal to the T cell, while the second signal is provided by interaction with costimulatory ligands on APC. CD2, LFA-1, and CD28 are the major costimulatory and adhesive molecules on T cells and bind to the LFA-3, ICAM
