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The key steps in cellular signaling and regulatory pathways rely on reversible noncovalent protein-ligand binding, yet the equilibrium parameters for such events remain challenging to characterize and quantify in solution. Here, we demonstrate a microfluidic platform for the detection of protein-ligand interactions with an assay time on the second timescale and without the requirement for immobili

Background: Migraine and Cluster Headache (CH) are two primary headaches with severe disease burden. The disease expression and the mechanisms involved are poorly known. In some attacks of migraine and in most attacks of CH, there is a release of vasoactive intestinal peptide (VIP) originating from parasympathetic cranial ganglia such as the sphenopalatine ganglion (SPG). Patients suffering from t

Denna rapport vänder sig i huvudsak till arbetsterapeuter och arbetsstuderande som arbetar eller kommer att arbeta med personer med psykiskt funktionshinder och deras aktivitetsproblematik. I början av rapporten beskrivs kortfattat vad psykiskt funktionshinder innebär och vad det kan betyda för en person att leva med psykiskt funktionshinder, främst gällande aktiviteter i vardagen utifrån aktuellFSA anser att det ligger ett stort värde i att arbeten av väsentlig betydelse för arbetsterapins och arbetsterapeuters utveckling, presenteras på ett lätttillgängligt sätt. Mot denna bakgrund har förbundet beslutat att ge ut FoU-rapporter. I denna FoU-rapport delger författaren Christel Leufstadius (Leg. Arbetsterapeut, Dr. med.vet.) oss information om att leva med psykiskt funktionshinder samt te

Making decisions between alternatives are challenging when there is weak or unreliable knowledge about the risks and benefits of the alternatives. This requires a trade-off between risks (and benefits). Here, we comment on a recent paper on risk–risk trade-offs and highlight the difficulties of making such trade-offs when the available evidence is of different strength. One current example of a ri

Efficient visible-light-driven photocatalysis can be achieved over conventional wide band gap semiconductor, in which iodinated SnO2 quantum dots (QDs) are synthesized via hydrolysis of crystalline SnI4 in the absence of any additives or templates. The formation of SnO2 QDs reveals a wide preparation window and a very fast growth rate in minute scale. The iodine species may only exist on the surfa

A few central transcription factors inside mouse embryonic stem (ES) cells and induced pluripotent stem (iPS) cells are believed to control the cells' pluripotency. Characterizations of pluripotent state were put forward on both transcription factor and epigenetic levels. Whereas core players have been identified, it is desirable to map out gene regulatory networks which govern the reprogramming o

We used temperature-programmed desorption (TPD) and reflection absorption infrared spectroscopy (RAIRS) to characterize the adsorption of NO on crystalline iron oxide films grown on Ag(111), including a Fe3O4(111) layer, an FeO(111) monolayer, and an intermediate FeOx multilayer structure. TPD shows that the NO binding energies vary significantly among the Fe cation sites present on these FeOx sur

Accumulation of intraneuronal inclusions, containing mainly a protein called alpha-synuclein (asyn), is thought to play a critical role in neurodegenerative disorders such as Parkinson's disease (PD). In these so called Lewy bodies, the majority of asyn is phosphorylated at serine 129 (pS129) suggesting that post-translational modifications may play a critical role in the process of aggregate form

The combination of complementary measurement techniques has become a frequent approach to improve scientific knowledge. Pairing of the high lateral resolution scanning force microscopy (SFM) with the spectroscopic information accessible through scanning transmission soft x-ray microscopy (STXM) permits assessing physical and chemical material properties with high spatial resolution. We present pro

Children of immigrants inherit human capital attainment from their parents that impact on their innovative performance. Some of this stem from their migrant parents’ positive and negative selection traits, part from their physical or cognitive proximity of country of origin to the host society. In this paper, I examine how second-generation immigrants (with at least one foreign-born parent), takin

Disaster risk management (DRM) requires the collaboration of a variety of stakeholders working in different sectors. They depend on each other to share risk information, and effective collaboration requires efficient communication. Clearly, the communication of risk descriptions is a key issue for the success of DRM activities. This study investigated the communication of risk-related information

Basophils are emerging as immunoregulatory cells capable of interacting with their environment not only via their characteristic IgE-mediated activation, but also in an IgE-independent manner. Basophils are known to express and respond to stimulation via TLR2, TLR4, DC-SIGN and DCIR, but whether basophils also express other C-type lectin receptors (CLRs) is largely unknown. In this study, we inves

Tropical forest loss and transformation to agroecosystems have serious impacts on biodiversity, associated ecosystem services and the livelihood of local people. The high crop plant biodiversity and low intensity management in many homegardens could play an important role in the preservation of biodiversity in modified landscapes, as well as sustain food security of low income households. In this