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Optical and laser diagnostics is a field where optical techniques are developed that offer remote, non-intrusive measurements in order to characterise a system. Imaging is a big part of this field and the versatility it offers makes it a great tool in the hands of researchers and in practical applications. In this thesis, multiple applications of imaging are presented, together with possible data
This article analyzes the use of metaphysics to speak of God within theology. More specifically, the charge of ontotheology levelled against Thomas Aquinas, in particular by Jean-Luc Marion and John Caputo, are being analyzed and criticized, not only with the help of thinkers like John Knasas and W. Norris Clarke, but also Marion himself. Because this article also examines the change of heart that
Title: Attitudes, cognition, and functional disability in individuals with self-harm and psychiatric disorders.Background: Self-harm is common and is associated with stigma and an increased risk for suicide attempts. There is a lack of knowledge about this behaviour, especially in clinical samples. Executive functions might be associated with self-harm, and there is also evidence that adverse chil
AbstractBackground: Areal bone mineral density (aBMD) measured by dual-energy X-ray absorptiometry (DXA) is a surrogate estimate of bone strength. The highest value in life is referred to “peak bone mass” (PBM). In the femoral neck (FN), PBM is reached late in the second decade in life, after which there is an age-related decline in aBMD during adulthood. However, a decrease in aBMD may follow a d
This thesis addresses the main challenges in using III-V nanowireMOSFETs for high-frequency applications by building a III-Vvertical nanowire MOSFET technology library. The initial devicelayout is designed, based on the assessment of the current III-V verticalnanowire MOSFET with state-of-the-art performance. The layout providesan option to scale device dimensions for the purpose of designing vari
Background: The effect of change in hip anatomy on change in gait pattern is not well described in current literature. Therefore, our primary aim was to describe and quantify changes in hip geometry and gait pattern 1 year after total hip arthroplasty (THA) in individuals with hip osteoarthritis. Our secondary aim was to explore the effect of postoperative change in femoral neck anteversion (FNA)
Highly pathogenic emm1 Streptococcus pyogenes strains secrete the multidomain Streptococcal inhibitor of complement (SIC) that binds and inactivates components of the innate immune response. We aimed to determine if naturally occurring or vaccine-induced antibodies to SIC are protective against invasive S. pyogenes infection. Immunisation with full-length SIC protected mice against systemic bacter
The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized by large biological heterogeneity with variable clinical outcomes. Here, we perform an integrative multi-omics analysis of patients diagnosed with NMIBC (n = 834). Transcriptomic analysis identifies four classes (1, 2a, 2b and 3) reflecting tumor biology and disease aggressiveness. Both transcriptome-based subty
Background: Detecting subtle-to-moderate biomarker changes such as those in amyloid PET imaging becomes increasingly relevant in the context of primary and secondary prevention of Alzheimer’s disease (AD). This work aimed to determine if and when distribution volume ratio (DVR; derived from dynamic imaging) and regional quantitative values could improve statistical power in AD prevention trials. M
This thesis focusses on a nuclear spectroscopy experiment conducted to study α-decay chains stemming from isotopes of flerovium (element Z = 114). An upgraded TASISpec decay station was placed behind the gas-filled separator TASCA at the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt, Germany. The fusion-evaporation reactions 48Ca + 242Pu and 48Ca + 244Pu provided a total of 29 flerovi
Jet substructure has provided new opportunities for searches and measurements at the LHC, and has seen continuous development since the optimization of the large-radius jet definition used by ATLAS was performed during Run 1. A range of new inputs to jet reconstruction, pile-up mitigation techniques and jet grooming algorithms motivate an optimisation of large-radius jet reconstruction for ATLAS.
A search for heavy resonances decaying into a pair of Z bosons leading to ℓ+ℓ-ℓ′ +ℓ′ - and ℓ+ℓ-νν¯ final states, where ℓ stands for either an electron or a muon, is presented. The search uses proton–proton collision data at a centre-of-mass energy of 13 TeV collected from 2015 to 2018 that corresponds to the integrated luminosity of 139 fb - 1 recorded by the ATLAS detector during Run 2 of the Lar
