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Human carbonic anhydrase IX (CA IX) is a multi-domain membrane protein that is therefore difficult to express or crystalize. To prepare crystals that are suitable for neutron studies, we are using only the catalytic domain of CA IX with six surface mutations, named surface variant (SV). The crystallization of CA IX SV, and also partly deuterated CA IX SV, was enabled by the use of microseed matrix

Stricter building regulations have resulted in the construction of buildings with a low energy use during the operation phase. It has now become increasingly important to also look at the embodied energy, because it might, over the lifespan of the building, equal the energy used for operating the building. One way to decrease the embodied energy is to reuse building materials and components or to

Aims: Chronic left atrial enlargement (LAE) increases the risk of atrial fibrillation. Electrocardiogram (ECG) criteria might provide a means to diagnose LAE and identify patients at risk; however, current criteria perform poorly. We seek to characterize the potentially differential effects of atrial dilation vs. hypertrophy on the ECG P-wave. Methods and results: We predict effects on the P-wave

This paper presents a procedure to derive a thermal lumped-parameter grey-box model of an electric machine built for traction. The procedure includes experimental data logged under overload conditions for accurate temperature prediction at high currents, and features a relatively simple loss estimation approach. Validation of the model shows a good fit between measured and simulated results. Possi

This article presents a concept of direct cooled windings for electrical machines, pumping air through hollow rectangular copper windings. The thermal constraints pose a serious limitation in the performance of many applications of electrical machines, not least in electrical vehicles. The difference between temporary maximum output and continuous output is often substantial. This difference can b

This paper explores and assesses power loss generation and heat extraction in a stator with directly air-cooled laminated winding. An electrical machine winding made of an electric conducting sheet, which have slotted structure for accommodating a magnetic core, is denoted a laminated winding. A space is introduced between the conducting sheets so that the heating power is removed right where it i

This paper presents and assesses the cooling integration of electrical machines with concentrated windings. A conventional coil in a concentrated winding with forced cooling applied on the exterior coil surfaces is replaced by an alternative solution where the coil is opened up in a laminar structure with the intention of the coolant fluid penetrating the coil and removing the interior heat. This

This paper explores the urban form, demographic and socio-economic dependencies of walking, cycling and e-biking in Beijing based on a survey (N = 1427) of daily travel among residents in eight neighborhoods, enriched with urban form variables. The results show that walking is most frequently used, followed by cycling, which in turn is more frequent than e-biking. Walking and cycling are preferred

The ISO 22400 has defined a set of Key Performance Indicators (KPIs) to evaluate the performance of manufacturing operation. Though the calculation formulas and tendency analysis of KPIs are given in the standard, it is important to evaluate how the standard performs when implemented in an industrial setting. Based on analyzing the production process in Volvo car, an aggregation KPI evaluation sys

Cities around the world are constructing bicycle infrastructure to increase cycling. However, identifying efficient design solutions and determining how bicycle infrastructure planning knowledge can be integrated into comprehensive policy remains a challenge. The objective of this paper is to shed light on the strengths and weaknesses of current bicycle infrastructure planning in both an experienc

University teachers’ engagement in teaching is a crucial aspect for the quality of student learning. In this article, we explore where such engagement comes from. We use a sociocultural perspective to investigate how teachers’ colleagues and leaders, in what we call academic microcultures, influence such engagement. A microculture can be a working group such as a teaching team, an educational progUniversity teachers’ engagement in teaching is a crucial aspect for the quality of student learning. In this article, we explore where such engagement comes from. We use a sociocultural perspective to investigate how teachers’ colleagues and leaders, in what we call academic microcultures, influence such engagement. A microculture can be a working group such as a teaching team, an educational prog

Controlled experiments on software variants enable e-commerce companies to increase sales by providing user-adapted functionality. Our goal is to understand how the context of experimentation influences tool support. We performed a case study at Apptus that develops algorithms for e-commerce. We investigated how the case company uses experiments through five semi-structured interviews. We identifi

Cycling plays an important role in low-carbon transitions. Around the globe, cities are constructing bicycle infrastructure. The city of Copenhagen has a bicycle-friendly infrastructure celebrated for its fine-meshed network. This study documents the spatio-temporal development of Copenhagen’s bicycle infrastructure and explores how the development corresponds to other processes of urban transform

Rapid urbanization and the growth in the number of motorized vehicles has dramatically marginalized cycling in Chinese cities since the end of the 1990s. The deterioration in air quality and the urban environment is severely challenging urban livability and public health. The cities are seeking effective policies to alleviate these problems, and revitalizing bicycle transport has received increasi

Objectives: This study examines the prevalence of pregnancy in serodiscordant couples and identifies predictors associated with pregnancy in rural Rakai, Uganda. Study design A population-based cross-sectional study that used data from the Rakai Community Cohort Study (RCCS). Setting and participants: We used data from the RCCS survey round 17 (2015-2016), which included 488 women in serodiscordan