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Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG-expansion in the gene encoding the protein huntingtin. The disease is characterized by progressive motor disturbances, cognitive defects, dementia, and weight loss. Using western blotting and immunohistochemistry we have assessed the expression levels and patterns of a number of proteins involved in neuro

With a simplified model in the Hartree-Fock-Bogoliubov (HFB) approximation, the behavior of weakly bound s(1/2) neutrons in the many-body pair correlation is studied by solving the HFB equation in coordinate space with the correct asymptotic boundary conditions. It is shown that in one-neutron pickup reactions on the even-even neutron-drip-line nuclei, which contain loosely bound s(1/2) neutrons,

This paper presents the experimental results of two different techniques, inductive degeneration and capacitive filtering, for reducing the phase noise in tail-biased RF CMOS voltage-controlled oscillators (VCOs). Both techniques prevent the low-frequency tail current noise from being converted into phase noise. The techniques are applied to two distinct VCO designs, showing that the largest phase

In this work it is shown that domains of ordered dipoles are formed in large droplets made from dipolar particles provided that the dipole-dipole interaction between nearest neighbors is larger than the thermal energy. The size of the domains grows almost linearly with the size of the droplets for droplets containing 1000-30 000 particles. The largest domains occupy around 25-35% of the droplet vo

Ab initio calculations including relativistic and correlation corrections were performed to obtain energy spectra and lifetimes for all states of first five configurations of Cl X.

Innovation has moved to the foreground in regional policy in the last decade. Concrete policies were shaped by “best practice models” derived from high-tech areas and well performing regions. These are often applied in a similar way across many types of regions. Here an attempt is made to show that there is no “ideal model” for innovation policy as innovation activities differ strongly between cen

The properties of quasi-two-dimensional semiconductor quantum dots are reviewed. Experimental techniques for measuring the electronic shell structure and the effect of magnetic fields are briefly described. The electronic structure is analyzed in terms of simple single-particle models, density-functional theory, and "exact" diagonalization methods. The spontaneous magnetization due to Hund's rule,

Nefrotoxicitet efter kontrastmedelstillförsel, räknat som en 25-procentig stegring av kreatinin i plasma, förekom hos 12 procent i en oselekterad grupp patienter som genomgått datortomografi. Generell arterioskleros kan läggas till övriga kända riskfaktorer för utveckling av kontrastmedelsnefrotoxicitet. Uppskattning av njurfunktion, t ex med hjälp av lämplig formel, bör göras före kontrastmedelst

Quantum oscillations of the spin conductance through regular and chaotic 2D quantum dots under the varying Rashba spin-orbit interaction and at zero magnetic field have been investigated numerically by summing up the spin evolution matrices for classical transmitting trajectories. The Fourier analysis of these oscillations indicates a strong geometry dependence of the power spectra. The spectra fo

Johannes of Rheinfelden’s treatise on card-playing, the Ludus cartularum moralisatus (“the moral meaning of card-playing”) is not only an important source of the history of plays and pastimes but also gives valuable information about late medieval thinking concerning the organization of human society. Johannes writes that the newly introduced cards were something of a revelation for him and that h

This study applies a state feedback-based Closed-Loop Combustion Control (CLCC) using Fast Thermal Management (FTM) on a multi-cylinder Variable Compression Ratio (VCR) engine. At speeds above 1500 rpm is the FTM's bandwidth broadened by using the VCR feature of this engine, according to a predefined map, which is a function of load and engine speed. Below 1500 rpm is the PID-based CLCC using VCR

The aim was to evaluate the clinical impact of P-glycoprotein in primary non-metastatic high-grade osteosarcoma patients, treated with neoadjuvant chemotherapy protocols. P-glycoprotein was assessed by immunohistochemistry on paraffin-embedded tissue samples collected at time of diagnosis from 94 osteosarcoma patients, treated with the Italian Sarcoma Group/Scandinavian Sarcoma Group 1 (ISG/SSG 1)

We analyze how the interaction between two hydrophobic surfaces in water depends on the amount of dissolved gas. At equilibrium there is, for a truly hydrophobic surface with contact angle theta > 90degrees, a long range attractive force. The attraction is due to the formation of a gaseous film between the surfaces. For a completely degassed sample the gas consists of water vapor and the range of

Popular Abstract in Swedish Faktor H är den viktigaste cirkulerande hämmare av den alternativa komplementvägen. Den fungerar som co-faktor för faktor-I medierad C3b nedbrytning, hindrar bildning av C3bBb konvertas och främjar dess nedbrytning. Genom att skilja mellan kroppens egna och främmande celler kan faktor H inhibera komplementmedierad värdcellsskada. Mutationer i faktor H har hittats hos paFactor H is the main fluid phase regulator of the alternative pathway of complement. Factor H acts as a co-factor for factor I-mediated C3b degradation, inhibits the formation of the C3bBb convertase and accelerates its decay. By discriminating between host and foreign cells, factor H inhibits complement-mediated injury to host cells. Factor H mutations have been associated with atypical hemolytic