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This study focuses on understanding how archaeologists interact with and reuse 3D data during excavation, drawing on an ad-hoc experiment and a discourse analysis approach taken from socio-linguistic disciplines. The experiment, conducted during the excavation of an Iron Age ‘central place’ in Sweden, reveals the multifaceted utility of 3D models in archaeological discussions. Our analysis shows t
Prussian blue (PB) nanozymes have emerged as durable enzyme-mimicking catalysts with broad applications across many fields. Practical uses often involve exposure to salinity that influences their colloidal and catalytic behaviors, yet the specific effects of ions on PB particles are underexplored. This study investigates how electrolyte type and concentration affect the colloidal stability and enz
In Alzheimer's disease (AD) there is accumulation of amyloid-β (Aβ) and hyperphosphorylated tau (pTau) in the brain. Aβ activates kinases that phosphorylate tau. Increased pTau181 is a signal for hyperphosphorylation of tau. The generation of Aβ from amyloid precursor protein (APP) and the release of heparan sulfate (HS) from the proteoglycan glypican-1 (GPC1) are interconnected. Release of HS is
Ibrutinib was approved for relapsed/refractory (R/R) mantle cell lymphoma (MCL) based on high response rates in clinical trials, but it is unclear how effective ibrutinib is in the real-world setting. This study provides population-based response rates and survival estimates and characterization of prognostic indicators and adverse events (AEs) to ibrutinib for patients with R/R MCL. All patients
“Seeding” is the addition of preformed fibrils to a solution of monomeric protein to accelerate its aggregation into new fibrils. It is a versatile and widely used tool for scientists studying protein aggregation kinetics, as it enables the isolation and separate study of discrete reaction steps contributing to protein aggregation, specifically elongation and secondary nucleation. However, the see
This paper aims to enhance our understanding of how strategic communication mobilise democratic values and ideals, which civil society is expected to support. Drawing on discourse theory, the paper conceptualises strategic communication as a process that unites various publics. This paper argues that these publics are largely imagined and constructed through communication. It also asserts that the
The Galactic center and inner disk of the Milky Way contain complex stellar populations obscured by heavy dust extinction. To study their chemical composition, high-resolution near-infrared (near-IR) spectroscopy is necessary. Expanding the set of elements measurable in the near-IR, especially neutron-capture elements, improves our ability to trace nucleosynthesis and Galactic chemical evolution.
Introduction: Vulvar cancer may cause serious local symptoms that may impact negatively on the woman's health-related quality of life (HRQOL). However, knowledge about the prevalence of vulvar and lymphedema symptoms at diagnosis and during follow-up is limited. The aim of this study was to evaluate the longitudinal development of vulvar and lymphedema symptoms as well as the trajectory of HRQOL i
In this 5th version of the European LeukemiaNet guidance for adult patients, there are important changes in several areas of management based on evidence available since 2020, including the World Health Organisation’s reclassification of CML as a biphasic disease. Previous advice to switch the tyrosine kinase inhibitor (TKI) on failure of molecular milestones, is modified to better account for ind
Background: Neoadjuvant cisplatin-based combination chemotherapy (NAC) is standard perioperative treatment of patients with muscle-invasive urothelial bladder cancer (MIBC); however, about half of the patients experience recurrence of the disease. Biomarkers for response and survival represent an unmet medical need. We used tumor specimens from transurethral resections of the bladder to explore ge
Background In ovarian cancer (OvCa), achieving complete resection (RO) in initial surgery is crucial for improving prognosis. However, patients with undetected microscopic metastasis post-RO surgery often have poorer outcomes. This study explores prognostic factors for OvCa patients who underwent RO surgery, focusing on the role of ascites cytology as an indicator of microscopic peritoneal metasta
Recent hydrodynamical simulations of isolated barred disc galaxies have suggested a structural change in the distribution of the interstellar medium (ISM) around a stellar mass M∗ of 1010 M⊙. In the higher-mass regime (M∗ ≤ 1010 M⊙), we observe the formation of a central gas and stellar disc with a typical size of a few hundred parsecs connected through lanes to the ends of the stellar bar. In the
Background: There has been an increasing number of single-centre studies describing the long-term outcomes of patients with Hirschsprung disease. This study aimed to systematically review the literature on long-term bowel, urological, and sexual functional outcomes, fertility and quality of life in adults with Hirschsprung disease. Methods: A PROSPERO-registered systematic review of the English li
Background: Decision-making regarding treatment limitations such as “Do not attempt resuscitation” (DNAR) orders for older patients has been found deficient. Patients ≥ 80 years with substantial comorbidity have little chance of surviving cardiac arrest, thus require thorough risk classification focusing on comorbidity and frailty. This study aimed to explore the degree of frailty, comorbidity and
Background: Previous literature indicate retinal hyperspectral imaging as a non-invasive method with the potential for identifying amyloid-beta (Aβ) protein deposits. Current diagnostic methods, such as cerebrospinal fluid analysis or positron emission tomography, are costly, invasive, and non-scalable. Hyperspectral imaging offers a potentially accessible alternative for early detection of Alzhei
Peanut (Arachis hypogaea L.) is globally recognized as an important oilseed crop. Traits related to plant architecture are closely associated with yield in peanut. In this study, we focused on four specific traits related to plant architecture—first branch length (FBL), main stem height (MSH), stem diameter (SD), and the number of nodes on the main stem (NSK)—across three locations. Using whole-ge
The transcriptional co-activators YAP (YAP1) and TAZ (WWTR1) are central regulators of vascular smooth muscle cell (VSMC) phenotype and vascular homeostasis. This study investigates the consequences of VSMC-specific YAP/TAZ deletion and its relevance to atherosclerosis. Using bulk and single-cell RNA sequencing data, we demonstrate that gene expression changes following two (2-week YT) and eight w
Plants take up carbon dioxide (CO2) through photosynthesis. How this will change with rising CO2 concentrations in the atmosphere will strongly determine future climate change. An increase in the seasonal variations of atmospheric CO2 in recent decades indicates a positive trend in photosynthetic carbon uptake. We combined data-driven seasonal cycles of plant productivity with carbon sinks across
This chapter reflects on the experiences – challenges, opportunities, considerations, consequences – of conducting field research as a parent. Through a series of reflections on and from field research, we locate our individual experiences as part of a broader conversation about conducting academic field research while a parent – and various decisions that need to be made, compromises reached, bar
