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Psoriasis (PSO) and psoriatic arthritis (PsA) are two related chronic inflammatory diseases. A proportion of people with PSO also develop PsA. PSO and PsA seem to have multiple impacts; from the health and well-being of the individual; to the need for healthcare resources for disease management; to the loss of productivity. Compared with other chronic diseases, such as heart disease and diabetes,

A method for optimization of PID controller parameters and measurement filter time constant is presented. The method differs from the traditional approach in that the controller and filter parameters are simultaneously optimized, as opposed to standard, sequential, design. Control performance is maximized through minimization of the integrated absolute error (IAE) caused by a unit step load distur

The genus Bicyclus is one of the largest groups of African butterflies, but due to the generally cryptic nature and seasonal variation of adult wing patterns, there has been a lot of systematic confusion. With a large research community working with the model species Bicyclus anynana there has been increasing interest in the evolutionary history of the genus. A previous phylogeny started to unrave

The surface charging behavior as a function of pH and isoelectric points (IEPs) of single-crystal α-Al2O3 (0001) and (1102) and α-Fe2O3 (0001) was determined by streaming potential measurements using an electrokinetic analyzer. The IEPs of α-Al2O3 (0001) and (11-02)$(1\overline1 02)$ and α-Fe2O3 (0001) were found to be 4.5, 5.1, and 6.5, respectively. These IEP values for oriented single crystals

Antibody-based proteomics offers distinct advantages in the analysis of complex samples for discovery and validation of biomarkers associated with disease. However, its large-scale implementation requires tools and technologies that allow development of suitable antibody or antibody fragments in a high-throughput manner. To address this we designed and constructed two human synthetic antibody frag

The relay autotuner provides a simple way offinding PID controllers of sufficient performance. By usingan asymmetric relay function the excitation of the process isimproved. This gives better models, and hence a better tuning,without increasing the time consumption or complexity of theexperiment. Some processes demand more accurate modelingand tuning to obtain controllers of sufficient performanceThe relay autotuner provides a simple way offinding PID controllers of sufficient performance. By usingan asymmetric relay function the excitation of the process isimproved. This gives better models, and hence a better tuning,without increasing the time consumption or complexity of theexperiment. Some processes demand more accurate modelingand tuning to obtain controllers of sufficient performance

Severe cerebral intraventricular hemorrhage (IVH) in preterm infants continues to be a major clinical problem, occurring in about 15-20% of very preterm infants. In contrast to other brain lesions the incidence of IVH has not been reduced over the last decade, but actually slightly increased. Currently over 50% of surviving infants develop post-hemorrhagic ventricular dilatation and about 35% deve

Background: There is a lack of understanding of the factors that influence independent mobility and participation in meaningful activities. The purpose of this study was to analyse physical factors influencing independent use of manual and power wheelchairs in a total population of children with cerebral palsy (CP). Methods: A cross-sectional study based on the most recent examination of all child

Next generation sequencing (NGS) methods have been widely used for diagnosis. As time and cost of sequencing has reduced sharply during the last decade, genome and exome-wide sequencing have increasingly been used. The genome and exome projects produce large amounts of variation data and the clinical relevance of large proportions of them are not known. Among various types of genetic variations, t

Grand challenges such as climate change put focus away from innovations and innovation policy as engines of economic growth towards fulfilling societal goals and sighting sustainable development. The literature on the geography of innovation has provided valuable insights on innovation activities of firms and industries and how they are positively influenced by co-location. In particular, short ge

The roots of mission studies are in the western missionary movement which had its heyday at the same time with the colonialist era. Academic mission studies which began a hundred years ago were confessional and served the interests of the western missions. With decolonisation and indigenisation of the majority world churches also mission studies underwent great changes. The study of world Christia

We present an intensive monitoring of high-resolution spectra of the Ca ii K line in the A7IV shell star φ Leo at very short (minutes, hours), short (night to night), and medium (weeks, months) timescales. The spectra show remarkable variable absorptions on timescales of hours, days, and months. The characteristics of these sporadic events are very similar to most that are observed toward the debr

Background While effective vocational methods for gaining employment exist for people with schizophrenia and similar conditions, no evidence exists with regard to people with affective disorders. We aimed to study the effectiveness of a newly developed Individual Enabling and Support (IES) model adapted for the target group and compared to traditional vocational rehabilitation (TVR). Methods An as

Introduction Inhibitor development in people with haemophilia is a serious complication that may require intensive and costly interventions. The goal of inhibitor management should be permanent inhibitor eradication through immune tolerance induction (ITI), but well-designed studies are lacking and the management of patients is therefore defined by the experience and views of the clinician. Object

Background: Parkinson's disease (PD) diagnosis is mainly based on clinical criteria, with a high risk of misdiagnosis. The identification of reliable biomarkers for disease diagnosis and progression has a key role for developing disease-modifying therapies. In this article, we investigated the longitudinal changes of CSF α-synuclein species in early PD patients and explored the potential use of th

Cognitively-normal people with evidence of β-amyloid (Aβ) pathology and subtle cognitive dysfunction are believed to be at high risk for progression to mild cognitive impairment due to Alzheimer's disease (AD). Clinical trials in later stages of AD typically include a coprimary endpoint to demonstrate efficacy on both cognitive and functional assessments. Recent trials focus on cognitively-normal

The aim of this study was to further investigate the psychometric properties (with focus on construct validity and scale function) of the Swedish version of the Person-centred Care Assessment Tool (P-CAT) in a sample consisting of staff working in elderly care units (N = 142). The aim was also to further develop and psychometrically test a modified, noncontext-specific version of the instrum