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Background: Many severe asthma patients with high oral corticosteroid exposure (HOCS) often do not initiate biologics despite being eligible. This study aimed to compare the characteristics of severe asthma patients with HOCS who did and did not initiate biologics. Methods: Baseline characteristics of patients with HOCS (long-term maintenance OCS therapy for at least 1 year, or ≥4 courses of stero

Objectives To assess whether recommendations of individually oriented lifestyle interventions (IOLIs) in guidelines from the National Institute for Health and Care Excellence (NICE) were underpinned by evidence of benefit, and whether harms and opportunity costs were considered.Design Cross sectional survey.Setting UK.Data sources NICE guidelines and supporting evidence.Eligibility criteria All NI

Purpose: The study aimed to define the genotypic and phenotypic spectrum of reversible acute liver failure (ALF) of infancy resulting from biallelic pathogenic TRMU variants and to determine the role of cysteine supplementation in its treatment. Methods: Individuals with biallelic (likely) pathogenic variants in TRMU were studied through an international retrospective collection of de-identified p

This chapter explores the value of gender equality in two areas of EU external relations: enlargement to include the accession countries of Central and Eastern Europe, and development policy with an emphasis on health, AIDS, and population policies. First, we will analyse the origins, history and institutionalisation of gender equality mechanisms in the European Union. Second, the impact of this v

Net-zero targets imply that continuing residual emissions will be balanced by carbon dioxide removal. However, residual emissions are typically not well defined, conceptually or quantitatively. We analysed governments’ long-term strategies submitted to the UNFCCC to explore projections of residual emissions, including amounts and sectors. We found substantial levels of residual emissions at net-ze

The pathogenic Legionella bacteria are notorious for delivering numerous effector proteins into the host cell with the aim of disturbing and hijacking cellular processes for their benefit. Despite intensive studies, many effectors remain uncharacterized. Motivated by the richness of Legionella effector repertoires and their oftentimes atypical biochemistry, also by several known atypical Legionell

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated wit

Den 9 september 2022 överlämnade Lunds universitet kraniet av en samisk man till Arjeplogs sameförening. Detta var den första återlämningen av en samisk kvarleva ur Lunds universitets anatomiska samling ...

Valutadeprecieringarna som följde på guldmyntfotens upplösning stimulerade den internationella ekonomin. Artikeln visar att länder som deprecierade endast tillfälligt eller inte alls fick fördelar på bekostnad av konkurrentländerna. Valutadeprecieringen ökade guldets värde och därmed de monetära reserverna, vilket gynnade återhämtningen från depressionen även för de länder som inte deprecierade. DThis article is the first examination of competitive devaluation in the 1930s using data on exchange rates. It analyses the impact of currency changes on foreign trade flows of fourteen industrialized countries 1929–1939. It reviews the development of nominal and real effective exchange rates together with trade and economic growth and conducts a disaggregated analysis of trade and bilateral excha

I den här artikeln ska jag framlägga argument för en kontroversiell tes. Nämligen att Islamiska förbundet i Sverige (IFiS), som äger och förvaltar Stora moskén på Södermalm i Stockholm, egentligen är en organisation som ingår i Muslimska brödraskapets (MB) nätverk av nationella organisationer och internationella samverkansorgan. MB är en legendarisk islamistisk organisation med rötter i Egypten, g

Background: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke. Methods: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective

A time projection chamber (TPC) with micropattern gaseous detector (MPGD) readout is investigated as main tracking device of the International Large Detector (ILD) concept at the planned International Linear Collider (ILC). A prototype TPC equipped with a triple gas electron multiplier (GEM) readout has been built and operated in an electron test beam. The TPC was placed in a 1 T solenoidal field

Analysis of DNA methylation is a valuable tool to understand disease progression and is increasingly being used to create diagnostic and prognostic clinical biomarkers. While conversion of cytosine to 5-methylcytosine (5mC) commonly results in transcriptional repression, further conversion to 5-hydroxymethylcytosine (5hmC) is associated with transcriptional activation. Here we perform the first st

Background and aims: Problem gambling causes major social and psychiatric consequences, and there is need to develop feasible harm-reducing or therapeutic interventions. It has been suggested that gambling operators with responsible gambling intentions can intervene in order to identify and help reduce the harm in problem gamblers. However, user satisfaction, and the risk of negative reactions and

Introduction This study aimed to determine the prevalence of unsafe listening practices from exposure to personal listening devices (PLDs) and loud entertainment venues in individuals aged 12-34 years, and to estimate the number of young people who could be at risk of hearing loss from unsafe listening worldwide. Methods We conducted a systematic review and meta-analysis to estimate the prevalence

The honeybee gut microbiome is thought to be important for bee health, but the role of the individual members is poorly understood. Here, we present closed genomes and associated mobilomes of 102 Apilactobacillus kunkeei isolates obtained from the honey crop (foregut) of honeybees sampled from beehives in Helsingborg in the south of Sweden and from the islands Gotland and Åland in the Baltic Sea.

For the supercritical n-decane horizontally flowing in a rectangular channel of an active regenerative cooling system, a transient thermal-fluid-structure coupling method is employed to investigate the unsteady thermal-hydraulic characteristics and the wall deformation at a starting stage. The temperature distributions of the fluid domain and solid domain along the flow direction are investigated

We investigate the quench dynamics of quasi-one- and two-dimensional dipolar Bose-Einstein condensates of Dy164 atoms under the influence of a fast rotating magnetic field. The magnetic field thus controls both the magnitude and sign of the dipolar potential. We account for quantum fluctuations, critical to formation of exotic quantum droplet and supersolid phases in the extended Gross-Pitaevskii

We investigate a Bose-Bose mixture across the miscible-immiscible phase transition governed by quantum fluctuations in one dimension. We find the recently predicted so-called mixed bubbles as ground states close to the mean-field miscible-immiscible threshold. These bubbles form a pocket of miscibility, separated by one of the components. The collective excitations reflect the symmetry breaking re