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TRIM22 (Staf50) is an interferon (IFN)-inducible protein with unknown function. Recently, we identified TRIM22 as a novel p53 target gene and showed that overexpression of TRIM22 inhibits the clonogenic growth of monoblastic U937 cells. Moreover, expression of TRIM22 is high in lymphoid tissue, and levels decrease during T lymphocyte activation with CD3/CD2/CD28, suggesting that TRIM22 could exert
1. We and others have shown that extracellular ATP (adenosine triphosphate), released from sympathetic nerves and platelets, stimulates growth of vascular smooth muscle cells (SMC). To study the importance of tyrosine kinases for ATP-mediated proliferation in vascular smooth muscle cells we used tyrphostins, a recently developed group of highly specific inhibitors of tyrosine kinases. 2. ATP induc
Process development, optimisation and robustness analysis for chromatography separations are often entirely based on experimental work and generic knowledge. The present study proposes a method of gaining process knowledge and assisting in the robustness analysis and optimisation of a hydrophobic interaction chromatography step using a model-based approach. Factorial experimental design is common
A set $C$ in a topological vector space is said to be weakly convex if for any $x,y$ in $C$ there exists $p$ in $(0,1)$ such that $(1-p)x+py\in C$. If the same holds with $p$ independent of $x,y$, then $C$ is said to be $p$-convex. Some basic results are established for such sets, for instance: any weakly convex closed set is convex.
Leukocyte recruitment in the liver includes a two-step procedure in which selectin-dependent leukocyte rolling is a prerequisite for subsequent CD18-dependent leukocyte firm adhesion in postsinusoidal venules. However, the roles of the individual selectins in leukocyte rolling and adhesion, hepatocellular injury, and apoptosis remain elusive. Therefore, we examined the pathophysiological role of P
Popular Abstract in Swedish Hjärnan är ett energikrävande organ och förbrukar ca 20% av blodets syre trots att den bara utgör 1-2% av kroppsvikten. Mitokondrien är den del av cellen där syre och näringsämnen förbränns till koldioxid och vatten, och mitokondrien kallas ofta för cellens kraftstation. Denna process, den så kallade cellandningen, är kopplad till produktion av den energirika molekylen There is currently no clinically available drug with neuroprotective properties to limit the evolving cell death following e.g. stroke or traumatic brain injury. The mitochondrial permeability transition (mPT) is a potential pathological mechanism causing cell death in the CNS. As the name implies, the mPT is defined by a sudden increase in permeability of the inner mitochondrial membrane, whose n
Placental grading was studied prospectively with real-time ultrasound in 654 consecutive pregnancies. The placental maturation was clearly demonstrated in both unselected and hypertensive pregnancies. No differences in placental grading were found between normotensive and hypertensive pregnancies. Fetal outcome was not associated with different placental grades and a grade III placenta was not pre
A record conversion efficiency of 11.4% at 100 GHz using a heretostructure barrier varactor (HBV) quintuplet is demonstrated. The quintupler is based on a microstrip circuit mounted in a full-height crossed-Nvaveguide block. The nonlinear element consists of a planar HBV diode fabricated in InGaAs/InAlAs/AlAs epitaxial layers on an InP substrate.
Pure Sb0.9V0.9O4 and various preparations with excess of either vanadia or antimony oxide, including mechanical mixtures, have been investigated for propane ammoxidation to acrylonitrile. The catalysts were characterized before and after use in catalysis by various methods, including electron microscopy, infrared spectroscopy and XPS. The catalytic data show that preparations with approximate to S
The construction sector has been criticised in recent years for being inefficient. The critique involved describes finished buildings as having flaws and there being a lack of interest within the construction sector in assembling knowledge and sharing experience. The construction industry has started working with questions of how efficiency can be increased by reducing the errors made. Knowledge
A kinetic model describing the enzymatic saccharification of wheat starch by a mixture of ol-amylase and amyloglucosidase has been developed. The model describes the influence of pH, glucose inhibition and starch and enzyme concentration, The results of experimental saccharification under different physical conditions, eg pH and temperature, were used to determine the parameters in the model. The
I rapporten redogörs för ett fältförsök med renovering av krypgrundläggning för småhus. För detta ändamål studerades sju likadana hus i samma kvarter under tre år. Fem hus försågs med markisolering i efterhand efter det att underkanten på bjälklaget i krypgrunden hade behandlats med borsyra. En annan förberedande åtgärd var att byta ut en på marken befintlig byggplastfolie mot fiberduk. Ett hus ha
In the past, little attention has been given to the role of brain plasticity for the long term functional outcome in experimental stroke although there is substantial evidence for plasticity in other experimental models of neurological disorders. Under clinical conditions, functional improvement occurs in most stroke survivors during the initial months after the ischemic incidence. Recent PET stud
The pathologic mechanisms of chronic obstructive pulmonary disease (COPD) most certainly involves neutrophil granulocytes, cytotoxic T-cells, macophages and mast cells. The aim of this study was to investigate the relation between the number of mast cells in different compartments in bronchial biopsies of central proximal airways to structural changes, lung function tests and emphysema detected by
