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Mechanisms of injury and repair in alveolar epithelial cells (AECs) are critically involved in the progression of various lung diseases including idiopathic pulmonary fibrosis (IPF). Homeobox only protein x (HOPX) contributes to the formation of distal lung during development. In adult lung, alveolar epithelial type (AT) I cells express HOPX and lineage-labeled Hopx+ cells give rise to both ATI an
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The aim of the Massive Open Online Course (MOOC) ‘Work and Technology on Human Terms’ was to be a modern, highly accessible study material in Ergonomics/Work science to contribute to safer and healthier workplaces. The course targets engineering students, but also students in economics, human relations, physiotherapy, occupational health, as well as professionals. The purpose of this paper is to d
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A recent approach for measurement program planning, GQM+Strategies, provides an important extension to existing approaches linking measurements and improvement activities to strategic goals and ways to achieve these goals. There is a need for instruments aiding in eliciting information from stakeholders to use GQM+Strategies. The success of GQM+Strategies highly depends on accurately identifying g
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An Inverse Heat Conduction Problem (IHCP) is considered in order to estimate the transient heat flux extracted from a hot solid surface by an impinging droplet. The resolution of the IHCP is made with the so-called quadrupole method, which provides an analytical expression of the temperature and the heat flux at the front surface of the solid wall, where the drop impact takes place. In the experim
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Several large-scale genome-wide association studies have identified single-nucleotide polymorphisms in the genomic region of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 repeats (ADAMTS)-7 and associations to coronary artery disease. Experimental studies have provided evidence for a functional role of ADAMTS-7 in both injury-induced vascular neointima formation and development of
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The specific way the Athenians set up their democracy presents both theoretical and empirical challenges. Decisions were taken by majority vote in the Assembly. To keep politicians in line, the Athenians first used ostracism, which however was replaced by the graphe paranomon around 415 BCE. The latter provided that anybody who had made a proposal in the Assembly could be accused of having made an
