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Objective: The objective of this study was to determine the predictive value of amyloid-positron emission tomography (PET) versus the plasma ratio of phosphorylated tau at threonine 217 (p-tau217) to non-phosphorylated tau217 (%p-tau217) for tau-PET transitions (T− to T+). The added value of combining plasma amyloid-β 42 and amyloid-β 40 (Aβ42/40) and %p-tau217 into an amyloid probability score (A

IMPORTANCE Upper gastrointestinal bleeding is common after myocardial infarction. OBJECTIVE To determine whether routine screening for Helicobacter pylori infection during hospitalization for myocardial infarction reduces bleeding events and improves clinical outcomes. DESIGN, SETTING, AND PARTICIPANTS A nationwide, open-label, 2-period, 2-sequence, cluster randomized, crossover clinical trial usi

INTRODUCTION: Since the last two decades, there has been a dramatic rise in caesarean sections (CS) throughout the world. This increase has been seen even in Europe, where rates vary significantly from 17% in Northern Europe to 56% in the South. Although, CS can be a lifesaving intervention when medically necessary, non-essential CS are associated with short- and long-term complications for both t

Importance Substantial improvements in childhood cancer survival have created a critical need to address serious long-term health complications, such as valvular heart disease (VHD). Objective To identify treatment-related risk factors for VHD in a large European cohort of long-term childhood cancer survivors. Design, Setting, and Participants This nested case-control study used data from the PanC

Nitrogen and phosphorous compounds are secreted by humans and treated in wastewater treatments plants. These substances are also found in agricultural fertilisers and needed for plant growth. Nutrient recycling is limited in conventional treatment systems and valuable products are lost. Urine contains most of the nutrients from humans and by separating it from wastewater it is possible to close th

Importance Identifying early proteomic profiles in infants who develop severe retinopathy of prematurity (ROP) may reveal targets for preventive interventions to reduce retinal vessel loss and the subsequent risk of severe ROP. Objective To assess early longitudinal profiles of blood protein levels in preterm infants with or without severe ROP and the effect of arachidonic acid (AA) and docosahexa

Importance: Understanding the relationship between patients' clinical characteristics and outcomes is fundamental to medicine. When critically ill patients die after withdrawal of life-sustaining therapy (WLST), the inability to observe the potential for recovery with continued aggressive care could bias future clinical decisions and research. Objective: To quantify the frequency with which expert

RATIONALE: Very preterm infants (i.e. born before 32 weeks of gestation) are at risk of cerebral injury and long-term neurodevelopmental impairment. Cerebral near-infrared spectroscopy (NIRS) enables continuous monitoring of cerebral oxygenation to guide clinical management. Interest in NIRS has grown in recent years, highlighting the need for better evidence to support its clinical efficacy in im

Background: Mammography screening programmes have been widely implemented across European countries over the past 40 years with the main aim to detect breast cancer earlier and thereby reduce breast cancer mortality. This study aimed to analyse and compare changes over time in breast cancer incidence, by stage at diagnosis, and breast cancer mortality across countries in relation to the timing of

Context. The Near InfraRed Planet Searcher (NIRPS) joined HARPS on the 3.6-m ESO telescope at La Silla Observatory in April 2023, dedicating part of its Guaranteed Time Observations (GTO) program to the radial velocity follow-up of TESS planet candidates to confirm and characterize transiting planets around M dwarfs. Aims. We present the “Sub-Neptunes” subprogram of the NIRPS-GTO, aimed at investi

The last decades have shown increased nitrogen leeching from soil to water recipients. This is in Sweden mainly due to over-manuring of agriculture land, effectivization of drainage systems and the declining extent of wetlands. The accumulated amount of nitrogen in water doesn’t only make it unsuitable for use by humans and cattle, but also decreases the biological diversity as well as negatively

Tidewater glaciers on Svalbard are sensitive indicators of climate change and play a crucial role for Arctic ecosystems. The widespread retreat of tidewater glaciers across Svalbard highlights the need to quantify retreat rates and project when these glaciers will become land-terminating. This study investigates tidewater glacier retreat during historical (1936–1990) and present (2012–2024) period

As cities increasingly turn to nature-based solutions (NBS) as panaceas for addressing climate challenges and other social, economic, and environmental issues, questions of urban governance and justice have become more prominent. While much of the existing literature on NBS justice assessments focuses on distributional aspects through quantitative methods, procedural justice remains underexplored,

Tropical peatlands in Central Kalimantan, Indonesia, represent important terrestrial carbon stores and support highly diverse tropical rainforest ecosystems with significant ecological, hydrological, and climatic functions. However, decades of drainage development, deforestation, plantation expansion, land-use change, and recurrent fire have contributed to extensive peatland degradation across the

This is a construction manual for the latest SolarFood indirect solar dryer at the time of publication. It is intended as a practical guide for carpenters, and assumes a basic level of carpentry experience.A Blender 3D model is also included alongside the manual.Further informationThe standard capacity of the dryer is around 5-10 kg depending on the crop, but can be scaled up or down as needed by

Super-resolution describes a technique for upscaling images from lower to higher resolution. This has proven successful for various applications, ranging from medical image analysis to building segmentation in remote sensing. However, the application of super-resolution to highly complex and dense surfaces, such as informal settlements, has not been widely examined. This is particularly relevant b

Importance Double awareness, the ability to live meaningfully while preparing for the end of life, is central to serious illness conversations. In hematology, prognostic uncertainty and expectations of novel therapies often delay prognostic dialogue, limiting opportunities to cultivate double awareness in patients and caregivers. Objective To explore how patients, caregivers, and hematology clinic