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Atrial fibrillation (AF) is a prevalent and morbid abnormality of the heart rhythm with a strong genetic component. Here, we meta-analyzed genome and exome sequencing data from 36 studies that included 52,416 AF cases and 277,762 controls. In burden tests of rare coding variation, we identified novel associations between AF and the genes MYBPC3, LMNA, PKP2, FAM189A2 and KDM5B. We further identifie
Neural simulation-based inference (NSBI) is a powerful class of machine-learning-based methods for statistical inference that naturally handles high-dimensional parameter estimation without the need to bin data into low-dimensional summary histograms. Such methods are promising for a range of measurements, including at the Large Hadron Collider, where no single observable may be optimal to scan ov
A set of measurements for the production of a W-boson in association with high-transverse-momentum jets is presented using 140 fb-1 of proton–proton collision data at a centre-of-mass energy of s=13 TeV collected by the ATLAS detector at the LHC. The measurements are performed in final states in which the W-boson decays into an electron or muon plus a neutrino and is produced in association with j
This paper presents measurements of top-antitop quark pair (tt¯) production in association with additional b-jets. The analysis utilises 140 fb−1 of proton–proton collision data collected with the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV. Fiducial cross-sections are extracted in a final state featuring one electron and one muon, with at least three or four b
In parallel with the exponential increase in extractivism around the world, comes social movements resisting such processes and advocating for alternative forms of development. Extractivism - a mode of accumulation associated with capitalism - is problematic due to the socio-ecological destruction that is embedded in its logics. Opposition to extractivism has intensified and in many instances, wom
We provide a detailed characterization of the planetary system orbiting HD 85426 (TOI-1774). This bright G-type star (: 0.99;: 1.13; age: 7.4 Gyr; V mag: 8.25) hosts a transiting sub-Neptune, HD 85426 b, with an orbital period of 16.71 d and a blackbody equilibrium temperature of K. By jointly analysing HARPS-N RVs, TESS, and CHEOPS photometric data and using two different stellar activity mitigat
Aging buildings will sooner or later be in need of renovation, which opens opportunities to reduce energy use. Even if economically feasible energy measures or technologies exist, they are not always implemented, leading to an energy efficiency gap. This dissertation deals with how energy measures are handled and why they are enabled or disabled during the planning and design of renovations. Durin
Estimations show that approximately US $23 billion is required for Georgia to meet its climate and environmental targets up to 2030. As the current Nationally Determined Contribution reveals, considering 1990 as a base year, the Republic of Georgia plans a 35% decrease in greenhouse gas emissions by 2030. If the country has financial and technical support, commitment to limit emissions may rise as
Water scarcity is one of the major challenges in semi-arid and arid areas. Drivers for water scarcity include climate change, population growth, economic, and agricultural development. This paper presents a framework for assessing water scarcity under the impact of climate, industry, and socio-economic changes in the Qazvin Plain, Iran. A system dynamics model is developed and calibrated using his
Herein, the grown-into-glass (GIG) CsPbBr3:Ln3+ (Ln = La, Lu) nanocrystals (NCs) are designed and fabricated using an in situ nanocrystallization method. It is shown that a substitution of Pb2+ sites with Ln3+ ions leads to a blueshift of emission position induced by an increase of the bandgap of CsPbBr3. Additionally, the GIG-samples are found to feature excellent photoluminescent (PL) properties
Antiarrhythmic effects of melatonin have been demonstrated ex vivo and in rodent models, but its action in a clinically relevant large mammalian model remains largely unknown. Objectives of the present study were to evaluate electrophysiological and antiarrhythmic effects of melatonin in a porcine model of acute myocardial infarction. Myocardial ischemia was induced by 40-min coronary occlusion in
This thesis investigates the weaponisation of healthcare in Ukraine during the ongoing conflict, analysing how deliberate attacks on medical infrastructure are not just violations of humanitarian law but systemic assaults on development, governance, and human security. Framed through a three-stage model: Disruption, Destabilisation, and Reconstruction, the study draws on Amartya Sen’s Development
As demand for nicotine pouches continues to grow globally, especially in the form of tobacco-free snus, efficient and scalable packaging solutions have become essential for producers. This report presents the design, development, and testing of a fully automated end-of-line packaging station using a collaborative robot (cobot), specifically the UR10e. The project was carried out in collaboration w
This study examines whether machine learning (ML) models can forecast daily Bitcoin price directions and generate statistically significant alpha in trading strategies. Employing a dual-model approach, we utilize a Random Forest (RF) classifier, leveraging its non-linear strengths and a LASSO-penalized logistic regression as a linear benchmark. Both models are trained on a comprehensive dataset o
