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Max Bengtsson A Site Selection of An Energy Island in the North Sea: Optimal Location in an Ecological and an Economic Scenario Using a Multicriteria Decision Analysis (MCDA). The Danish Government has decided to build an energy island, either as an artificial island in sand, concrete and steel or as a platform solution in the Danish exclusive economic zone (EEZ) of the North Sea. The idea of the
BackgroundExercise is a cornerstone of chronic obstructive pulmonary disease (COPD) management and improves quality of life, exercise capacity, exacerbation frequency and survival. However, the physiological mechanisms underlying these effects remain unclear. Small airway dysfunction and airway remodeling may not be adequately captured by spirometry, whereas impulse oscillometry (IOS) may be more
CSF concentrations of β-amyloid 42 (Aβ42) and phosphorylated tau (p-tau) are well-established biomarkers of Alzheimer's disease and have been studied in relation to several neuropathological features both in patients and in cognitively unimpaired individuals. The CSF p-tau/Aβ42 ratio, a biomarker combining information from both pathophysiological processes, has emerged as a promising tool for moni
Importance: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive symptoms and amyloid pathology. Objective: To examine the association between depressive symptoms and amyloid pathology and its dependency on age,
Importance: The incidences of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) have increased markedly over recent decades, raising concerns about the emergence of new risk factors. Current literature typically attributes increased rates to changes in diagnostic practice, stigmatization, and awareness, but critically few studies have explored changes in underlying
According to TCO (The Swedish Confederation for Professional Employees) the worst threat to the Swedish welfare is that so many people because of bad health and unemployment are not a part of the labour force. If Sweden could make the number of people with health and unemployment problems half the size as today, the GDP would increase with more than five percent. In real money this means 110 billi
Background Prostate-specific membrane antigen (PSMA)-PET usage in patients with prostate cancer is growing rapidly. Thus, novel risk-group definitions based on PSMA-PET are urgently needed for guidelines, clinical use, and trial study design. We report improved risk classification based on PSMA-PET Prostate Cancer Molecular Imaging Standardized Evaluation (PROMISE; PPP) nomograms (PPP3) to prognos
Most of the key membrane materials used in industry today were developed in the 1960s and 1970s. The dominant materials on the market include polysulfone, polyethersulfone, polyvinylidene fluoride (PVDF), and polyamide. These materials continue to be the backbone of membrane technologies, owing to their well-established performance, durability, and cost-effectiveness. However, despite significant
BACKGROUND: Sexual violence against older adults in humanitarian settings is poorly documented, leading to gaps in prevention and delivery of support services. This study aimed to document differences in assault characteristics between younger and older adults, by sex and displacement and disability status and region. METHODS: This retrospective, descriptive observational, multi-country study incl
Importance: Tau positron emission tomography (PET) allows in vivo detection of neurofibrillary tangles, a core neuropathologic feature of Alzheimer disease (AD). Objective: To provide estimates of the frequency of tau PET positivity and its associated risk of clinical outcomes. Design, Setting, and Participants: Longitudinal study using data pooled from 21 cohorts, comprising a convenience sample
Introduction Parkinson’s disease (PD) is a common neurodegenerative disease, which has extensive pathology that critically includes the loss of midbrain dopaminergic neurons. This loss leads to debilitating motor features such as bradykinesia and rigidity, as well as some non-motor symptoms. Intracerebral dopamine cell transplants have been explored for many years as a new approach to treating PD
BACKGROUND: Limbic-predominant age-related TDP-43 encephalopathy (LATE) clinically mimics and often co-occurs with Alzheimer's disease (AD). Expert consensus criteria have been proposed for the LATE clinical diagnosis, integrating clinical and radiological features, and AD biomarkers. Here, we applied the newly proposed criteria in a tertiary memory clinic population. METHOD: We included participa
IMPORTANCE: Robot-assisted surgery (RAS) is increasingly used for abdominal procedures; however, postoperative pulmonary complications (PPCs) are more frequent in patients undergoing RAS compared with patients undergoing conventional laparoscopic surgery (CLS).OBJECTIVE: To compare the incidence of PPCs after CLS and RAS and to determine which patient-, surgery-, and anesthesia-related factors are
Background: Recent advances have highlighted the potential of artificial intelligence (AI) systems to assist clinicians with administrative and clinical tasks, but concerns regarding biases, lack of regulation, and potential technical issues pose significant challenges. The lack of a clear definition of AI, combined with limited focus on qualitative research exploring clinicians' perspectives, has
2641Background: BI-1808 is an IgG1 mAb that target TNFR2 by blocking interaction of TNFR2 with ligand TNF-α, confers FcγR-dependent depletion of Treg and mediates expansion of intratumoral CD8+ T cells. Upon co-administration of murine surrogate antibodies targeting TNFR2 and anti-PD-1 to immunocompetent tumor-bearing mice with partial sensitivity to checkpoint blockade, complete cures were observ
As media consumption becomes increasingly individualized, people’s desire for shared cultural experiences remains. Reaction media provides one way to fulfil that need, fostering transnational community (Swan 2018) and a sense of co-presence and immediacy. In their most basic form, reaction media show people filming themselves or being filmed while reacting – viewing, eating, playing, trying out or
MASTER (MAnaging Speeds of Traffic on European Roads) aims to provide recommendations for speed management strategies and policies and to elaborate guidelines for the development of innovative speed management tools. Within the framework of the project, field trials with a car equipped with a speed limiter were carried out in three “regional typical” European countries: Sweden, the Netherlands, an
Background: Up-to-date estimates of stroke burden and attributable risks and their trends at global, regional, and national levels are essential for evidence-based health care, prevention, and resource allocation planning. We aimed to provide such estimates for the period 1990–2021. Methods: We estimated incidence, prevalence, death, and disability-adjusted life-year (DALY) counts and age-standard
Rodent models are important research tools for studying the pathophysiology of traumatic brain injury (TBI) and developing new therapeutic interventions for this devastating neurological disorder. However, the failure rate for the translation of drugs from animal testing to human treatments for TBI is 100%. While there are several potential explanations for this, previous clinical trials have reli
Importance: Studies have suggested an increased risk of psychiatric disorders and suicidal behavior among individuals who have undergone tonsillectomy. However, little is known about stress-related disorders. Objective: To investigate whether surgical removal of tonsils or adenoids is associated with a subsequent risk of stress-related disorders. Design, Setting, and Participants: This cohort stud
