Filtyp
The ionizable-lipid component of RNA-containing nanoparticles controls the pH-dependent behavior necessary for an efficient delivery of the cargo - the so-called endosomal escape. However, it is still an empirical exercise to identify optimally performing lipids. Here, we study two well-known ionizable lipids, DLin-MC3-DMA and DLin-DMA using a combination of experiments, multiscale computer simula
Purpose: We assessed long-term outcomes in acutely admitted adult patients with delirium treated in intensive care unit (ICU) with haloperidol versus placebo. Methods: We conducted pre-planned analyses of 1-year outcomes in the Agents Intervening against Delirium in the ICU (AID-ICU) trial, including mortality and health-related quality of life (HRQoL) assessed by Euroqol (EQ) 5-dimension 5-level
Background: Most family studies on venous thromboembolism (VTE) have focused on first-degree relatives. Objectives: We took a pedigree-based approach and examined the risk of VTE and cardiometabolic disorders in offspring from extended pedigrees according to the densities of VTE in pedigrees. Methods: From the Swedish population, we identified a total of 482 185 pedigrees containing a mean of 14.2
Frihetstiden driver fram ett unikt statsskick i Sverige, världens första tryckfrihetslag och en rad civila rättigheter. Tankar om att makten ska var lojal mot folket, snarare än mot Gud och kungen, är upptakten till genomgripande samhällsomvälvningar som tar fart med den europeiska upplysningen.
The use of artificial intelligence (‘AI’) is ubiquitous in society today. It has contributed towards advancements in diverse fields such as healthcare, transportation, public administration and in helping humanity to solve pressing challenges such as climate change. As AI increasingly plays a larger role within our daily lives and in society, it is inevitable that human rights issues will arise in
A stencil-adaptive SBP-SAT finite difference scheme is shown to display superconvergent behavior. As proof of concept, applied to the linear advection equation, it has a convergence rate O(Δx4) in contrast to a conventional scheme, which converges at a rate O(Δx3).
BackgroundRevised diagnostic criteria for infective endocarditis (IE), the 2023 Duke-ISCVID criteria, were recently presented and need validation. Here, we compare the 2000 modified Duke criteria for IE with Duke-ISCVID among patients with bacteremia and relate the diagnostic classification to IE-treatment.MethodsWe reanalyzed patient cohorts with Stapylococcus aureus, Staphylococcus lugdunensis,
Maritime archaeology excavations, even in a more complex environment, have the same objectives and requirements as terrestrial ones: documenting digging operations to analyze data in the best way, interpreting it, and producing new knowledge for the benefit of multiple communities. 3D documentation and management methodologies have spread widely among practitioners; however, 3D comprehensive tools
Transportsektorn är en central och nödvändig del av det moderna samhället samtidigt som den också ger upphov till flera negativa samhällseffekter. Sådana effekter är till exempel emissioner av växthusgaser, partiklar och andra föroreningar som har en negativ påverkan på människors hälsa och miljön. Andra effekter är till exempel buller och olyckor som har en negativ effekt på människors hälsa. Syf
The backbone of modern computing systems rely on two key things: logic and memory, and while computing power hasseen tremendous advancements through scaling of the fundamental building block – the transistor, memory access hasn’tevolved as rapidly, leading to significant memory-bound systems. Additionally, the rapid evolution of machine learningand deep neural network (DNN) applications, has expos
