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Tuberös skleros är en svår medfödd sjukdom där majoriteten också har epilepsi. Trots tung krampförebyggande medicinering är det få som uppnår anfallsfrihet och många har fortsatt dagliga anfall. Det enda sätt vi i nuläget känner till för att helt bota epilepsi är epilepsikirurgi. Men hur ska vi veta vilka som gynnas av sådan kirurgi och vilka som kan skadas?

Individuals’ use of co-speech gestures mostly parallels the verbal cross-linguistic patterns of spoken languages. In this review paper, we synthesize research findings and discuss individuals’ co-speech gesture production across four concepts (space, time, event, and emotion) that are encoded and expressed differently across languages. These four concepts reflect the wide variation across spoken l

Microbial communities frequently encounter recurrent antibiotic disturbance, yet how ecological, evolutionary, and environmental processes jointly shape community responses remains unresolved. Here, we use priming to describe the history-dependent effect whereby prior exposure alters the response to a subsequent disturbance. Using a 23-species bacterial community exposed to sequential ampicillin p

Importance: The incidences of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) have increased markedly over recent decades, raising concerns about the emergence of new risk factors. Current literature typically attributes increased rates to changes in diagnostic practice, stigmatization, and awareness, but critically few studies have explored changes in underlying

Even though complex microbial communities are ubiquitous and provide essential services for natural and human-associated ecosystems, our knowledge about their assembly and dynamics is incomplete. There is an ongoing debate about whether the behavior of complex communities can be predicted from the outcome of pairwise competition of species, and whether communities reach alternative stable states d

The Creative Health Review (CHR) published in 2023 is an advocacy document by the UK National Centre for Creative Health and the All-Party Parliamentary Group on Arts, Health and Wellbeing. The CHR defines creative health activities as visual and performing arts, crafts, film, literature, cooking, gardening, and visits to cultural centres and heritage sites and claims that active promotion of such

Tool Coating is a method for enhancing cutting efficiency and extending tool life, essential for machining hard materials. While Polycrystalline Cubic Boron Nitride (PcBN) tools are already well-suited for harsh machining conditions, their durability can be further improved with coatings. However, as the machining operation continues, tool coating loss occurs, reducing the durability of the tool a

Insects are the most abundant and ecologically important animal migrants. Yet, we know relatively little about the patterns and processes underlying insect migration. Dragonflies (Anisoptera) and damselflies (Zygoptera) comprise the ancient insect order Odonata, whose ancestors were the first organisms to fly on Earth. Several members of Odonata are known to migrate long distances and have conside

0D Sb3+-based organic-inorganic hybrid metal halide (OIMH) scintillators have gained significant attention due to their efficient self-trapped exciton (STE) emission. However, the interplay between local structural distortion, defect-states, and STE emission remains insufficiently understood. Herein, two structurally distinct 0D Sb3+-based OIMHs, [HP(o-tol)3]2SbBr5 and [HP(m-tol)3]4SbBr7, are inve

The RELOC-AGE program addresses knowledge gaps on associations between housing, relocation, and active and healthy aging. The aim of this study was to investigate preferred housing attributes, and whether such attributes differed depending on desired type of dwelling or individual characteristics, among adults in Sweden aged 55 years and older with an expressed interest in relocation. From the Pro

The present nationwide population-based study compared minimally invasive surgery (MIS) with open surgery (OPEN) for colorectal cancer during a period when MIS was introduced in Sweden. The primary analyses demonstrated that MIS was not inferior compared with OPEN regarding short-term outcome for patients operated 2012-2018, nor for long-term outcome assessed as overall survival with surgery perfo

Magnetic fields are a key factor in the evolution of planets and their atmospheres, but they are still poorly constrained for exoplanets owing to limited direct observations. Ultra-hot Jupiters provide a new avenue to probe magnetic effects, as the circulation of their highly ionized atmospheres could be directly sensitive to the atmospheric magnetic field. However, it remains unclear whether the

Symptomatic knee osteoarthritis at an early structural stage could provide a window of opportunity for intervention. Symptomatic knees without definite radiographic osteoarthritis can already show structural joint changes detectable on MRI; however, the greater sensitivity of MRI must be balanced against the risks of overdiagnosis and overtreatment.

Thyroid function has been suggested to be associated with breast cancer risk, but not much is known about thyroid hormones as a potential prognostic factor for breast cancer. This study investigated the relation between thyroid hormones in breast cancer patients and mortality. A total of 2000 breast cancer patients from the Swedish SCAN-B cohort were followed for 9 years. Blood samples were collec

There is currently widespread concern that rapid technological change will funda-mentally change the nature of work. In this paper we show that, despite 140 years oftechnological change, more than 70 percent of employment today is located in occu-pations whose core economic functions already existed in the late nineteenth century.Full-count Swedish census and administrative data from 1880 to 2019,

Industrial robotic manipulators are widely used in manufacturing for high-speed pick-and-place operations. Therefore, there is value in optimizing the trajectory execution speed and positional accuracy to reduce cycle times. However, pushing these acceleration limits often induces structural residual vibrations at the end-effector, which degrade process quality and necessitate long settling times.

At the European Spallation Source (ESS), the Beamline for European materials Engineering Research (BEER) instrument aims to position samples within the neutron beam using a robotic arm system, given the high flexibility and large end-effector workspace provided by robotic arms. However, precise and accurate sample positioning is limited by the pose accuracy capabilities of industrial robotic arms,

Single-cell RNA sequencing (scRNA-seq) has opened new possibilities for studying the dynamic interplay between circadian rhythms and cell cycle progression at the level of individual cells. This thesis explores circadian-related transcriptional signals and their possible relationship with cell cycle activity in human bone marrow cells using publicly available scRNA-seq data from healthy donors. Si

Recent advancements in GPU-accelerated simulation have made it possible to train reinforcement learning policies for robotic control using large-scale parallel data collection. This thesis explores the pipeline from task description to deployment of control policies on the robot platform Spot. The focus is on two important skills needed for future loco-manipulation tasks: robust standing and comma