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In septic shock, administration of large fluid volumes is associated with poor outcomes. Recent evidence shows that non-resuscitation fluids are the major modifiable source of fluids for patients with septic shock in intensive care units (ICUs). This clinical trial is designed to test the hypothesis that restrictive administration of non-resuscitation fluids improves outcomes compared to usual car

The human cathelicidin LL-37 is active against both bacteria and viruses, but it also shows immunomodulatory properties. Here, we assess the impact of LL-37 on viral signaling in human airway epithelial BEAS-2B cells infected with the respiratory pathogen rhinovirus (RV). We show that LL-37 (4 μM) enhances RV-induced expression of interferon β (IFNβ) transcript and reduces viral-load. LL-37-evoked

Ordered arrays of nanocrystals, called supercrystals, have attracted significant attention owing to the collective quantum effects arising from the coupling between neighboring nanocrystals. In particular, lead halide perovskite nanocrystals are widely used because of the combination of the optical properties and faceted cubic shape, which enables the formation of highly ordered supercrystals. The

We carried out the first high-resolution transit observations of the exoplanet WASP-49 Ab with Keck/HIRES. Upon custom wavelength calibration we achieve a Doppler RV precision of < 60 m s−1. . This is an improvement in RV stability of roughly 240 m s−1 with respect to the instrument standard. We report an average sodium flux residual of (Formula presented) per cent t (8.0σ) comparable to previous

The presence of microplastics (MPs) in water represents a current problem for marine life and a future serious issue for human health. This is pushing towards new approaches for the removal of MPs and, hence, their characterization and evaluation, which up to now has represented a limit for tentative procedures for their degradation. Herein, we reported on a new facile, in situ and non-destructive

Super-resolution microscopy (SRM) has revolutionized life sciences by overcoming the diffraction limit, enabling the visualization of biological structures at the nanoscale. Expansion Microscopy (ExM) has emerged as a powerful and accessible technique that enhances resolution by physically enlarging the specimen. Importantly, the principles of ExM provide a unique foundation for combinations with

Variance-reduced stochastic gradient methods have gained popularity in recent times. Several variants exist with different strategies for storing and sampling gradients, and this work concerns the interactions between these two aspects. We present a general proximal variance-reduced gradient method and analyze it under strong convexity assumptions. Special cases of the algorithm include SAGA, L-SV

Background and Aims: Previous studies have shown that procalcitonin (PCT) concentration is elevated in patients with liver disease without evidence of bacterial infection. We aimed to investigate the association between elevated PCT and the future risk of liver disease. Method: PCT was measured in 3897 individuals without known liver disease in the Malmö Diet and Cancer Cardiovascular Cohort (MDC-

Business Continuity Management (BCM) is an approach aimed at ensuring the continued delivery of essential functions during crises. While BCM originates from the private sector, it has increasingly also been adopted by public sector organizations. Yet, no comprehensive overview of peer-reviewed literature on public sector BCM and its largely equivalent counterpart, Continuity of Operations Planning

Early B-type stars with initial masses between 8 and 15 M are frequently found in multiple systems, as is evidenced by multi-epoch spectroscopic campaigns in the Milky Way and the Large Magellanic Cloud (LMC). Previous studies have shown no strong metallicity dependence in the close-binary (a < 10 au) fraction or orbital-period distributions between the Milky Way’s solar metallicity (Z) and that o

Background: Perioperative myocardial injury (PMI) is associated with increased short-term major adverse cardio- and cerebrovascular events (MACCE) and mortality. We evaluated how different phenotypes of PMI based on timing of injury impact long-term MACCE and mortality among patients undergoing major noncardiac surgery (NCS). Methods: A prospective, observational study was carried out in 1290 pati

Objective: Classification of fetal heart rate (FHR) decelerations as suspicious or pathological differs between current interpretation templates for intrapartum cardiotocography. Decelerations are the most frequent FHR pattern irregularities during labour. The aim of this study was to assess the association between different types and characteristics of decelerations and acidemia at birth. Methods

This book provides a highly accessible and user-friendly overview of the essential concepts and terms related to the current global endeavour to implement the Sustainable Development Goals.With the first decade of the 15-year timespan of the 2030 Agenda now past, the SDGs show limited progress and several goals are even regressing. It is imperative that SDG implementation is accelerated until 2030

This A-Z Guide offers an accessible and user-friendly overview of the essential concepts and terms needed to understand the implementation of the SDGs. Crafted in the form of an encyclopaedia, the volume presents 105 entries on important concepts and terms and their links to academic and policy debates. Each entry offers basic definitions of the concept or term at issue, followed by a brief discus

In 2013, the United Nations General Assembly established the High-level Political Forum on Sustainable Development (HLPF) as a central platform for the review and follow-up of the 2030 Agenda and the Sustainable Development Goals (SDGs). Every year, government representatives and societal stakeholders meet to assess progress of SDG implementation. The HLPF can be seen as a soft governance instrume

International organizations within and outside the United Nations system provide platforms for multilateral cooperation and give impulses for national policymaking to promote the implementation of the Sustainable Development Goals (SDGs). They set agendas, coordinate efforts across regions and countries, offer technical assistance and expertise, compile data and monitor progress, and raise awarene