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Background: Posttraumatic stress disorder (PTSD) and substance use disorders (SUD) frequently co-occur in youth. Integrated, trauma-focused treatments are recommended, but evidence in youth is limited and the dynamics of symptom change are poorly understood.Objectives: We investigated within-treatment changes in PTSD and substance use, and their temporal sequencing, in a randomised controlled tria
Antibiotic resistance poses a significant threat to human health, and wastewater treatment plants (WWTPs) are important reservoirs of antibiotic resistance genes (ARGs). Here, we analyze the antibiotic resistomes of 226 activated sludge samples from 142 WWTPs across six continents, using a consistent pipeline for sample collection, DNA sequencing and analysis. We find that ARGs are diverse and sim
The first measurement of the polarisation of coherently photoproduced J/ψ mesons in ultra-peripheral Pb–Pb collisions, using data at sNN=5.02 TeV, is presented. The J/ψ meson is measured via its dimuon decay channel in the forward rapidity interval −4.0
Background: Asthma characterization using blood eosinophil count (BEC) (among other biomarkers and clinical indices) is recommended in severe asthma (SA), but the masking effect of oral corticosteroids (OCS), makes this challenging. Aim: Our aim was to explore the effect of OCS use (both intermittent [iOCS] and long-term [LTOCS]) prior to biologic initiation on SA phenotype and biomarker profile i
Six coumarins were isolated from two bioactive fractions of the 70% ethanol extract from the twigs and leaves of Wikstroemia indica (L.) C.A. Mey. (Thymelaeaceae), namely the ethyl acetate fraction (WIE) and the water fraction (WIW). These compounds were identified as umbelliferone (1), daphnoretin (2), daphnorin (3), adicardin (4), wikstronutin (5), and triumbelletin-7-O-β-D-glucoside (6). Compou
Complement factor C3 is one of the most abundant proteins in the bloodstream and a central part of the complement system. Upon activation, C3 facilitates bacterial recognition and clearance in the extracellular environment. Initially regarded as a serum effector component, C3 is also emerging as an intracellular protein regulating basic cellular processes. Previously, we reported that intracellula
We document a substantial glass ceiling in the Swedish labor market: women constitute less than 20% within the top 1% of the earnings distribution. Using a structural micro-founded model of a dual earner household with learning-on-the-job, we link this to the child penalty. While on parental leave, women accumulate less human capital on the job, get promoted to a lesser extent, and hence are less
Kin recognition, the ability to identify genetic relatives, relies on familiarisation for the creation of recognition templates. During development, parent and embryo(s) are exposed to chemical, auditory, and tactile cues that can communicate reliable genetic information. We discuss how these cues can have organisational effects during a time of heightened phenotypic sensitivity, creating postnata
Purpose: Boys with genetic syndromes have an increased risk of undescended testes (UDT), but laparoscopic findings and outcomes after two-stage Fowler-Stephens orchiopexy (FS2) are rarely reported. This study aims to compare laparoscopic findings and results after FS2 between syndromic and non-syndromic boys. Methods: A retrospective cohort study on boys with UDT who underwent laparoscopy between
Questions: Earth observation is an important tool in biological monitoring. Previous studies have shown that variation in grassland canopy reflectance can explain gradients in plant community composition. However, there is a need for methods that allow the interpretation of the overall spectral signal of complex grassland vegetation in terms of existing knowledge about individual species' habitat
A double-swirler ammonia/methane co-flame burner was developed to enhance flame stability and reduce NOx emissions in ammonia combustion. In this system, a premixed ammonia/air mixture is introduced through the inner swirler, while a lean premixed methane/air flame from the outer swirler stabilizes the ammonia/air flame. Experimental results highlight that the Reynolds number of the outer methane/
Kidney paired donation (KPD) programs are organized in various countries to facilitate the donation of kidneys from willing but incompatible donors by matching them with pairs in similar situations. These programs often struggle with an accumulation of difficult-to-match recipients and small pools of incompatible pairs. To address this, several international collaborations have emerged to expand t
Chronic care manages long-term, progressive conditions, while acute care addresses short-term conditions. Chronic conditions increasingly strain health systems, which are often unprepared for these demands. This study examines the burden of conditions requiring acute versus chronic care, including sequelae. Conditions and sequelae from the Global Burden of Diseases Study 2019 were classified into
The shift toward battery electric vehicles (EVs) represents the most profound disruption in the automotive industry in over a century, with far-reaching consequences for European automotive regions. For decades, incremental improvements in internal combustion engine (ICE) technologies have served as the dominant decarbonization pathway, and many regions have built strong innovation systems around
Although Global Digital Elevation Models (GDEMs) are widely used, their spatial error distributions over extensive regions remain insufficiently understood. Using ICESat-2 Reference Control Points (RCPs) (~ 30 points/km²), this paper not only evaluates GDEMs with point-based metrics such as Root Mean Square Error (RMSE) and Mean Error (ME), but also proposes a novel raster-independent Spatial Erro
This article examines forced migrants’ decision-making over time on movement from first country of asylum. Building on 150 in-depth interviews with Syrian refugees (A note on terminology: the term refugee is used colloquially by our participants, other scholars, the legal profession, and international actors to denote most Syrian migrants, yet it often means different things to its users. While ma
This study presents the first measurement of the f1(1285) resonance using the ALICE detector in inelastic proton–proton collisions at a center-of-mass energy of 13 TeV. The resonance is reconstructed at midrapidity (|y|< 0.5) through the hadronic decay channel f1(1285)→KS0K±π∓. Key measurements include the determination of its mass, transverse-momentum integrated yield, and average transverse mome
This study examines disaster risk perception and communication in Albania, focusing on two districts in the cities of Tirana and Fier and the villages of Novosela and Dajç, all affected by severe flooding in recent years. The research highlights how dimensions of national culture - particularly fatalism and attachment to home and hearth - interact with contextual, psychological, and demographic ch
Despite growing emphasis on home-based rehabilitation following stroke, there remains limited understanding of how to effectively tailor services to individual needs. This study employed concept mapping to explore diverse stakeholder perspectives on adapting home-based rehabilitation to better support the recovery process after stroke. Through this mixed-methods participatory approach, we engaged
