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Concrete is one of the most commonly used construction material on the earth after water. The compressive strength of concrete is an important parameter and is considered in all structural designs. Production of the cement is directly proportional to carbon emissions. The cement content in the concrete can be partially replaced with waste materials like steel fibers, silica fumes, etc. Calculating
Columns are the important structural elements to transfer the superstructures load to the foundation. Deterioration and degradation of the structural elements is the critical issue facing by the entire world. Corrosion is one of the most common cause responsible for the deterioration. To maintain structural safety as well as serviceability, it is important to estimate the residual capacity of the
The term smart grid refers to an electrical grid system that incorporates a range of operating and energy initiatives including advanced metering, intelligent distribution boards and circuit breakers, load control switches and smart devices, and renewable energy resources. The incorporation of the internet of things (IoT) into the smart grid, called the internet of energy things-smart grid (IoET-S
This chapter presents a simulation model for the optimization of a reservoir system that is being developed. Simulation studies were carried out, firstly to determine the best (and by how much) irrigation facilities to provide in the proposed new scheme, and secondly, to see the applicability of simulation in reservoir planning. A computer simulation model using MATLAB has been developed to analyz
Agriculture is a backbone of the Indian economy, nowadays farmers are facing manpower problem, it may be due to migration of the manpower, and they need to manage the infinite resources in agriculture. Computer application for precise management is a novel weapon to increase the utilization of resources efficiently. Crop-dusting is a farmer's tedious, repetitive work, which drones will take over t
Many filters such as triple-band filter, multiband filter, UWB filter, and notch band filters have been investigated in recent decades [1]. Bandpass filters with the features of good performance, micro-package, ease of use, and low cost have been the focus of device miniaturization. However, most of these UWB filters with band-notched have been designed by using various slots either in the ground
Background: Employment is a vital source for experiencing well-being and lowering the risk of long-term social marginalisation and poverty. For persons with alcohol and drug addiction, it may also improve sobriety. However, the unemployment situation for this group reflects the knowledge gap in effective interventions to support employment. While Individual Placement and Support (IPS) is recognise
Insulin is packaged into secretory granules that depart the Golgi and undergo a maturation process that involves changes in the protein and lipid composition of the granules. Here, we show that insulin secretory granules form physical contacts with the endoplasmic reticulum and that the lipid exchange protein oxysterol-binding protein (OSBP) is recruited to these sites in a Ca2+-dependent manner.
Cemented carbide inserts coated with CVD α-alumina, particularly those exhibiting a (0001) texture, have proven highly effective in steel turning. Despite the established superior performance of (0001) textured alumina coatings, the underlying reasons remain unclear. This study explores the influence of the crystallographic texture of alumina on wear mechanisms in various chip-tool contact zones o
OBJECTIVE: The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are inflammatory disorders with ANCA autoantibodies recognising either proteinase 3 (PR3-AAV) or myeloperoxidase (MPO-AAV). PR3-AAV and MPO-AAV have been associated with distinct loci in the human leucocyte antigen (HLA) region. While the association between MPO-AAV and HLA has been well characterised in East A
OBJECTIVE: Niemann-Pick Type C (NPC) is a genetic neurodegenerative lysosomal storage disorder commonly associated with psychiatric symptoms and delays to accurate diagnosis and treatment. This study investigated biomarker levels and diagnostic utility of plasma neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in NPC compared to healthy controls. METHODS: Patients with NP
Introduction: Neurofilament light chain (NfL), a blood biomarker of neuronal injury, shows promise in distinguishing neurodegenerative disorders from psychiatric conditions. This is especially relevant in psychosis, given neurological conditions such as autoimmune encephalitis and Niemann Pick Type C disease (NPC) may initially present with psychotic symptoms. Whilst NfL levels have been studied i
BackgroundSocial and geographical inequity in access to primary healthcare is an ongoing concern in Sweden. Digital care can potentially decrease geographical inequity. This study aimed to evaluate how urbanicity affects the utilization of a public digital primary healthcare service - PHC Online.MethodsWe performed an ecological cross-sectional study of 4,482 PHC Online visits grouped by 83 public
In the cell, stalled ribosomes are rescued through ribosome-associated protein quality-control (RQC) pathways. After splitting of the stalled ribosome, a C-terminal polyalanine 'tail' is added to the unfinished polypeptide attached to the tRNA on the 50S ribosomal subunit. In Bacillus subtilis, polyalanine tailing is catalyzed by the NEMF family protein RqcH, in cooperation with RqcP. However, the
Bacteria have evolved sophisticated mechanisms to deliver potent toxins into bacterial competitors or into eukaryotic cells in order to destroy rivals and gain access to a specific niche or to hijack essential metabolic or signaling pathways in the host. Delivered effectors carry various activities such as nucleases, phospholipases, peptidoglycan hydrolases, enzymes that deplete the pools of NADH
The target of zero emissions sets a new standard for industry and industrial policy. Industrial policy in the twenty-first century must aim to achieve zero emissions in the energy and emissions intensive industries. Sectors such as steel, cement, and chemicals have so far largely been sheltered from the effects of climate policy. A major shift is needed, from contemporary industrial policy that ma
This thesis has investigated three different diagnoses where cardiac microvascular disease is suspected: hypertrophic cardiomyopathy (HCM), systemic sclerosis (SSc), and patients with suspected microvascular angina (MVA).Study I of this thesis investigated patients with HCM. We investigated the myocardial perfusion (MP) using cardiac magnetic resonance imaging (CMR) in young patients with HCM or t
