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Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk : An IMI DIRECT study

Background: Dietary advice remains the cornerstone of prevention and management of type 2 diabetes (T2D). However, understanding the efficacy of dietary interventions is confounded by the challenges inherent in assessing free living diet. Here we profiled dietary metabolites to investigate glycaemic deterioration and cardiometabolic risk in people at risk of or living with T2D. Methods: We analyse

The chair and the performative practice in contemporary church settings. : A study of seating in rooms of worship in the Church of Sweden.

Seating of churches is crucial to how the building is used, experienced and structured. The liturgical practice and contemporary use of seating of chairs play a fundamental part for the participatory performance on a liturgical stage. The long tradition of close interaction between church and nation, society and contemporary material culture, plays part in shaping the design process of the physicaSeating of churches is crucial to how the building is used, experienced and structured. The liturgical practice and contemporary use of seating of chairs play a fundamental part for the participatory performance on a liturgical stage. The long tradition of close interaction between church and nation, society and Contemporary material culture, plays part in shaping the design process of the physica

Multiplicity dependence of π , K, and p production in pp collisions at √s=13 TeV

This paper presents the measurements of π±, K ±, p and p ¯ transverse momentum (pT) spectra as a function of charged-particle multiplicity density in proton–proton (pp) collisions at s=13TeV with the ALICE detector at the LHC. Such study allows us to isolate the center-of-mass energy dependence of light-flavour particle production. The measurements reported here cover a pT range from 0.1 to 20 GeV

Artificial neural networks improve early outcome prediction and risk classification in out-of-hospital cardiac arrest patients admitted to intensive care

BACKGROUND: Pre-hospital circumstances, cardiac arrest characteristics, comorbidities and clinical status on admission are strongly associated with outcome after out-of-hospital cardiac arrest (OHCA). Early prediction of outcome may inform prognosis, tailor therapy and help in interpreting the intervention effect in heterogenous clinical trials. This study aimed to create a model for early predict

Proteomic investigation of protein adsorption to cerebral microdialysis membranes in surgically treated intracerebral hemorrhage patients - A pilot study

Background: Cerebral microdialysis (CMD) is a minimally invasive technique for sampling the interstitial fluid in human brain tissue. CMD allows monitoring the metabolic state of tissue, as well as sampling macromolecules such as proteins and peptides. Recovery of proteins or peptides can be hampered by their adsorption to the CMD membrane as has been previously shown in-vitro, however, protein ad

Synthesis, phase structure and ion conductivity of poly(p-phenylene) functionalized with lithium trifluoromethanesulfonimide and tetra(ethylene oxide) side chains

Rigid-rod polymers tethered with delocalized anions and flexible ion conductive side chains present a synthetic pathway towards thin, single-ion conducting electrolyte membranes with low bulk resistance and high mechanical stability. In the present work we have synthesized poly(p-phenylene) (PpP) copolymers carrying lithium trifluoromethanesulfonimide groups and tetra(ethylene oxide) side chains t

3D Structure and Mechanics of Silk Sponge Scaffolds Is Governed by Larger Pore Sizes

Three-dimensional scaffolds play an essential role in tissue engineering. Although essential, the tunability of the 3D scaffolds mechanical and transport properties remains a challenge. In this work, we present new approaches to advance the field. First, we applied our progressive pH acidification to mimic the natural silk gelation process before ice-templating (−20 and −80°C); second, we fitted t

On the reduction of negative weights in MC@NLO-type matching procedures

We show how a careful analysis of the behaviour of a parton shower Monte Carlo in the vicinity of the soft and collinear regions allows one to formulate a modified MC@NLO-matching prescription that reduces the number of negative-weight events with respect to that stemming from the standard MC@NLO procedure. As a first practical application of such a prescription, that we dub MC@NLO-∆, we have impl

Probing multi-step electroweak phase transition with multi-peaked primordial gravitational waves spectra

Multi-peaked spectra of the primordial gravitational waves are considered as a phenomenologically relevant source of information about the dynamics of sequential phase transitions in the early Universe. In particular, such signatures trace back to specific patterns of the first-order electroweak phase transition in the early Universe occurring in multiple steps. Such phenomena appear to be rather

Hur tolkas och tillämpas begreppet föräldraansvar vad gäller insatser till barn enligt LSS och ersättningar enligt SFB?

På uppdrag av Riksförbundet FUB har en granskning genomförts av tolkning och tillämpning av begreppet ”normalt föräldraansvar” och vad detta innebär i relation till olika stöd- och serviceinsatser enligt lagen om stöd och service till vissa funktionshindrade (LSS). Vidare har Försäkringskassans tolkning och tillämpning av begreppet utifrån ersättningar som ges via Socialförsäkringsbalken (SFB) und