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Cardiac xenotransplantation has seen remarkable success in recent years and is emerging as the most promising alternative to human cardiac allotransplantation. Despite these achievements, acute vascular rejection still presents a challenge for long-term xenograft acceptance and new insights into innate and adaptive immune responses as well as detailed characterizations of signaling pathways are ne
Intervju med Charlotte Sjödell, avdelningen för industridesign vid LTH, Lunds universitet, i Sydsvenska dagbladet med anledning av AI utställning på Southern Sweden Design Days, 2023. I artikeln nämns också boken om form av Charlotte Sjödell med titeln "The Artifact Description Library" och som är gjord med hjälp av Chat GPT.
The processes responsible for the formation of Earth's most conspicuous diversity pattern, the latitudinal diversity gradient (LDG), remain unexplored for many clades in the Tree of Life. Here, we present a densely sampled and dated molecular phylogeny for the most speciose clade of damselflies worldwide (Odonata: Coenagrionoidea) and investigate the role of time, macroevolutionary processes, and
BakgrundLångvarig behandling med opioida läkemedel, här definierat som> 3 månader, på indikation långvarig icke-malign smärta är vanligt förekommande i smärtvården. Vid undersökningar i Lund och Linköping har noterats att ungefär en tredjedel av populationen vid smärtklinikerna exponeras för opioidbehandling, trots avsaknad av evidens och samtidigt väl kända risker med behandlingen. Nedtrappning a
Preclinical transplantations using human neuroepithelial stem (NES) cells in spinal cord injury models have exhibited promising results and demonstrated cell integration and functional improvement in transplanted animals. Previous studies have relied on the generation of research grade cell lines in continuous culture. Using fresh cells presents logistic hurdles for clinical transition regarding t
Evaluating the (Formula presented.) scaling function of elastic proton–proton ((Formula presented.)) collisions from recent TOTEM data at (Formula presented.) TeV and comparing it with the same function of elastic proton–antiproton ((Formula presented.)) data of the D0 collaboration at (Formula presented.) TeV, we find, from this comparison alone, an at least 3.79 (Formula presented.) signal of od
This book invites you to embark on a journey of discovery, where words become the palette for the expression of design. Furthermore, this book extends its utility to individuals working with Al and text-to-image creation. By enhancing the effectiveness of prompts, it empowers Al systems like Stable Diffusion, DALL-E, and MidJourney to produce refined and contextually relevant visual outputs. The t
This article explores the links between intolerance of urban noise and emerging notions of privacy in mid-eighteenth-century Altona, a southern provincial town in the Danish monarchy. It focuses on Johann Peter Willebrand (1719–86), who dealt with urban noise both as Altona’s police director and as an intellectual and author of several influential books on the ideal organization of early modern ci
Background This study aimed to describe the initial treatment of clubfoot deformity in Sweden using a national cohort. Secondarily we aimed to analyse the results of the initial treatment in relation to foot severity and additional diseases. Methods A national register, the Swedish Pediatric Orthopedic Quality Register, was used to extract data on children born with clubfoot in 2016–2019. Children
The interplay between aging and immune system deterioration presents a formidable challenge to human health, especially in the context of a globally aging population. Aging is associated with a decline in the body’s ability to combat infections and an increased risk of various diseases, underlining the importance of rejuvenating the immune system as a strategy for promoting healthier aging. In iss
A healthy working life is fundamental for individuals and society. To date, increasingly research connects the earlier, pre-working life to later working life experiences and beyond, recognizing that a worker’s health and exposure starts before the working life begins. The research, however, often lacks a fundamental understanding of (i) the underlying mechanisms and pathways accounting for differ
BACKGROUND: This study aimed to identify the roles of L-tryptophan (Trp) and its rate-limiting enzymes on the receptivity of bovine endometrial epithelial cells. Real-time PCR was conducted to analyze the differential expression of genes between different groups of bovine endometrial epithelial cells. Western blot was performed to detect Cyclooxygenase-2 (COX2) expression after treatment with Trp
Aim: There is ongoing controversy regarding the extent to which Hartmann's procedure (HP) should be used in rectal cancer treatment. This study was designed to investigate 30-day postoperative morbidity and mortality following HP, anterior resection (AR) and abdominoperineal resection (APR) for rectal cancer using a national registry. Methods: All patients operated for rectal cancer, tumour height
Rolando Garcı́a nos enseña que el marco socio-polı́tico determina en alguna medida el marco epistémico e influye igualmente en la estructura social del campo cientı́fico. Una recorrida por los acontecimiento principales, para la civilización europea, desde el presente hasta mediados de siglo XIX nos permiten poner a prueba esta tesis. En lugar de una “historia de las ideas”, una narrativa históric
This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High-dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of patients have decreased and 19% severely depleted spermatogonial pool prior to HSCT. Patients with Fanconi a
This article studies the interrelations of memory work and activism in the Iranian context by focusing on the way remembering victims of state violence informs political activism. Due to constant repression, the recurrence of state violence and the criminalisation of oppositional activities and non-conforming lifestyles, the Iranian context is saturated with contentious memories that cannot be bro
Introduction: Galectin-3 is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human KD = 25 nM; rabbit KD = 12 nM) and high oral bioavailability in rabbits and man. In this study the efficacy of
Context. The light element (anti-)correlations shown by globular clusters (GCs) are the main spectroscopic signature of multiple stellar populations. These internal abundance variations provide us with fundamental constraints on the formation mechanism of stellar clusters. Aims. Using Gaia-ESO, the largest and most homogeneous survey of open clusters (OCs), we intend to check whether these stellar
