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Background: There are two conceptually different surgical treatment options for patients with T1 colorectal cancer (CRC): radical surgical resection and local resection. In addition, adjuvant chemotherapy is recommended in cases with lymph node metastases. However, surgical overtreatment of early CRC is a concern and may be related to limitations in preoperative work-up as well as tumour risk clas

Rates of cognitive decline in Alzheimer’s disease (AD) are extremely heterogeneous. Although biomarkers for amyloid-beta (Aβ) and tau proteins, the hallmark AD pathologies, have improved pathology-based diagnosis, they explain only 20–40% of the variance in AD-related cognitive impairment (CI). To discover novel biomarkers of CI in AD, we performed cerebrospinal fluid (CSF) proteomics on 3,397 ind

Parkinson's disease (PD) is a progressive neurodegenerative disorder with a growing global burden. Current pharmacological therapies remain limited to symptomatic management, owning to an incomplete understanding of the mechanisms driving α‑synuclein aggregation and disease progression. This review provides an integrated overview of PD across epidemiological, etiological, pathophysiological, and c

Background: Virtual imaging trials (VITs) are in silico studies that simulate medical imaging and disease processes, offering a cost-effective and reproducible addition to traditional imaging trials. While VITs are well established in breast imaging, most existing implementations simulate imaging based on static anatomical models, capturing only a single time point. This limits their ability to st

Perceiving appreciation at work has positive individual and organizational outcomes. Managers in particular are attributed with responsibility to communicate appreciation to employees and to support cultivating an appreciative working environment. This study aims to provide an in-depth analysis of managers’ communication responsibility based on qualitative diaries conducted in five European countr

Background: Surviving sudden cardiac arrest often lead to long-term cognitive, emotional, and physical consequences. Although clinical guidelines recommend structured post-cardiac arrest follow-up, such follow-up is often lacking or inconsistent. Tailored digital interventions are scarce but may help address gaps in follow-up resources. The CARDIS trial evaluates the effects on patient-reported ouBackground: Surviving sudden cardiac arrest often lead to long-term cognitive, emotional, and physical consequences. Although clinical guidelines recommend structured post-cardiac arrest follow-up, such follow-up is often lacking or inconsistent. Tailored digital interventions are scarce but may help address gaps in follow-up resources. The CARDIS trial evaluates the effects on patient-reported ou

With the increasing prevalence of microplastics (MPs) and nanoplastics (NPs) in global aquatic environments, their potential ecotoxicological and health impacts have become a major concern in environmental science. Slow sand filtration (SSF) is widely recognized for its low energy demand, ecological compatibility, and operational stability; however, its efficiency in removing small or neutrally bu

Background People with Parkinson’s disease (PD) need life-long rehabilitative interventions to slow disease progression and reduce impact of the disease on daily life activities. To be sustainable for the individual, activities should have a positive impact on physical, cognitive and mental health, and should be appealing and meaningful. Aim To quantitatively evaluate the health-related effects of

Background and aims: Gynoid fat (hip-thigh subcutaneous adiposity) is metabolically favorable, yet its genetic architecture and impact on liver diseases are unknown. We aimed to identify genetic determinants of gynoid tissue fat percentage (GTFP) and explore their clinical implications to liver disease. Methods: We conducted a genome-wide association study (GWAS) in 37,385 European individuals fro

BackgroundOsteocalcin is a bone-specific protein involving many physiological processes, primarily bone turnover. Also closely related to the musculoskeletal system is the frailty syndrome.AimTo investigate if circulating osteocalcin levels and frailty are associated in the old, and in addition, if the presumed association is mediated through alterations in bone.Methods999 community-dwelling women

Polyunsaturated fatty acids (PUFA) have been shown to reduce liver fat compared to saturated fat, but effects of a novel “anti-lipogenic” diet replacing carbohydrates with PUFA (LCPUFA) or a low-fat healthy Nordic diet (HND) rich in whole-grains are unknown. The objective of this study was to investigate the effects of these diets, as compared with usual care (UC), on liver fat (primary outcome) a

Context. The chemical abundances of alpha elements in Galactic Centre (GC) supergiants provide key insights into the chemical enrichment and star formation history of the Milky Way’s nuclear star cluster. Previous studies have reported enhanced alpha-element abundances, which raises questions about the chemical evolution of this unique region. Aims. We aim to reassess the alpha-element abundances

Background The answer to whether females or males have better health, and which sex is the more disadvantaged, has depended in part on the metric and how the inequality is measured. This study introduces a new method for analyzing and interpreting sex inequalities in health outcomes—defined as the avoidable sex differences in health outcomes—that is systematic and potentially more objective. For t

Wearable devices are becoming a cornerstone for personalized and long-term health monitoring, enabling early intervention and data-driven medical decisions. In this work, we present e-Glass, a state-of-the-art smart wearable device that enables unobtrusive real-time electroencephalography (EEG) monitoring. Our evaluation shows that e-Glass adheres to the established international guidelines for cl

We present a novel method combining existing cosmological simulations and orbital integration to study the hierarchical assembly of globular cluster (GC) populations in the Milky Way (MW). Our method models the growth and evolution of GC populations across various galactic environments as well as the dynamical friction and mass loss experienced by these objects. This allowed us to follow the traje

The cell cycle is a key regulator of endothelial cell specification into tip and stalk cell phenotypes, which are essential for angiogenesis in both normal development and pathological conditions. While the tumor suppressor p53 is known to regulate the cell cycle and influence cell fate, its role in modulating the cell fate of these phenotypes remains unclear. Using non-genotoxic small molecule an

Scholte wave surveys were conducted at both the laboratory and field scales to evaluate the reliability of distributed acoustic sensing (DAS) with a fiber-optic cable resting on top of unconsolidated sedimentary deposits to determine the distribution of S-wave velocity underneath. Laboratory measurements performed in a controlled environment at the Deltares Laboratory facility demonstrated that DA