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Multidimensional encoding of restricted and anisotropic diffusion by double rotation of the q vector

Diffusion NMR and MRI methods building on the classic pulsed gradient spin-echo sequence are sensitive to many aspects of translational motion, including time and frequency dependence ("restriction"), anisotropy, and flow, leading to ambiguities when interpreting experimental data from complex heterogeneous materials such as living biological tissues. While the oscillating gradient technique speci

Knowledge, Attitude and Worry in the Kurdistan Region of Iraq during the Mpox (Monkeypox) Outbreak in 2022 : An Online Cross-Sectional Study

The rapid spread of monkeypox (mpox) has been declared as a public health emergency of international concern (PHEIC). The present study aimed to assess the knowledge, attitude, and worry levels of the general population in the Kurdistan region of Iraq regarding the ongoing mpox multi-country outbreak. An online cross-sectional survey was conducted between 27–30 July 2022, using a convenience sampl

Pancreatic Cancer Organoids : An Emerging Platform for Precision Medicine?

Despite recent therapeutic advances, pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies, with remarkable resistance to treatment, poor prognosis, and poor clinical outcome. More efficient therapeutic approaches are urgently needed to improve patients’ survival. Recently, the development of organoid culture systems has gained substantial attention as an emerging

Searching for the nature of stars with debris disks and planets

The nature of the few known solar-mass stars simultaneously containing debris disks and planets remains an open question. A number of works have shown that this property appears to be independent of planetary masses as well as of stellar age, but possible correlations with stellar kinematics and metallicity have not been investigated. In this paper, we show that the majority of known stars contain

Regional CO2 Inversion Through Ensemble-Based Simultaneous State and Parameter Estimation : TRACE Framework and Controlled Experiments

Atmospheric inversions provide estimates of carbon dioxide (CO2) fluxes between the surface and atmosphere based on atmospheric CO2 concentration observations. The number of CO2 observations is projected to increase severalfold in the next decades from expanding in situ networks and next-generation CO2-observing satellites, providing both an opportunity and a challenge for inversions. This study i

Differential Effects of Iron Chelates vs. Iron Salts on Induction of Pro-Oncogenic Amphiregulin and Pro-Inflammatory COX-2 in Human Intestinal Adenocarcinoma Cell Lines

We previously showed that two iron compounds that are orally ingested by humans, namely ferric EDTA and ferric citrate, can induce an oncogenic growth factor (amphiregulin) in human intestinal epithelial adenocarcinoma cell lines. Here, we further screened these iron compounds, plus four other iron chelates and six iron salts (i.e., 12 oral iron compounds in total), for their effects on biomarkers

Distribution of type 2 biomarkers and association with severity, clinical characteristics and comorbidities in the BREATHE real-life asthma population

Background Type 2 (T2) high asthma is recognised as a heterogenous entity consisting of several endotypes; however, the prevalence and distribution of the T2 biomarkers in the general asthma population, across asthma severity, and across compartments is largely unknown. The objective of the present study was to describe expression and overlaps of airway and systemic T2 biomarkers in a clinically r

Comparison of Ultrafast Dynamic Contrast-Enhanced (DCE) MRI with Conventional DCE MRI in the Morphological Assessment of Malignant Breast Lesions

Ultrafast (UF) dynamic contrast-enhanced (DCE)-MRI offers the potential for a faster and, therefore, less expensive examination of breast lesions; however, there are no reports that have evaluated whether UF DCE-MRI can be used the same as conventional DCE-MRI in the reading of morphological information. This study evaluated the agreement in morphological information obtained from malignant breast

Organometallic complexes with antimalarial properties

Popular Abstract in Swedish Malaria är en allvarlig febersjukdom som varje år drabbar nästan 250 miljoner människor. Sjukdomen är mycket utbredd inom tropiska och subtropiska delar av världen och världshälsoorganisationen (WHO) har beräknat att strax under en miljon människor, majoriteten av dem barn, dör av malaria varje år. Malaria har följt människan under mycket lång tid och var länge vanlig iMalaria is a serious disease that causes around 800 000 deaths per year. Current malaria control efforts are hampered by the widespread resistance to common antimalarial drugs, such as the 4-aminoquinoline derivative called chloroquine. Previous research has shown that specific modifications of chloroquine, including inclusion of organometallic fragments into the organic framework, can result in c

Reflektion och självinsikt i "den kommunikativa pedagogiken"

Popular Abstract in Swedish I Tallsten barnomsorgs- och skolenhet införde man 1996, som del i en omorganisation av verksamheten, ett nytt tanke- och arbetssätt utifrån en kommunikativ pedagogik. Tre mindre organisatoriska enheter, som var mer eller mindre slutna i förhållande till varandra, slogs samman till en enhet. Ett primärt syfte i sammanhanget var att skapa en helhetssyn på barnet från 1?18This thesis focuses on the pedagogue as a social being and how she or he experiences the social life in preschools and schools in Tallsten. In 1996, the child-care and education authorities in Tallsten introduced a new manner of thinking and working based on the communicative pedagogy. The idea of communicative pedagogy was origanlly put forth by the Danish teacher Lars Rokkjaer. One of the goals

Custom Designed Digital Signal Processors Using Bit-Serial Arithmetic

This thesis presents two prime contributions. First, digital filters for both intermediate and base band filtering for mobile communication are presented. Second, a local clock for on-chip clock generation is introduced. The intermediate frequency filter is a digital alternative to today's analog filters. It is a narrow band filter designed for the American digital mobile telephone system accordin

Framgångsrika skolledare i spänningsfält och allianser

Vad gör en skolledare framgångsrik? Och vad gör en framgångsrik skolledare? I denna artikel presenteras några resultat från forskningsprojektet Framgångsrikt skolledarskap i olika skolkulturer, vilka delvis utgör svar på frågorna. Resultaten härrör från intervjuer, enkäter, observationer och elevuppsatser och utgörs av olika skolaktörers kriterier för bedömning av skolledares framgång. I likhet me

Methods for Correction of Images of Origami/Polyhedral Objects

This paper deals with line-drawings, obtained from images of polyhedral objects after edge detection. Such images are used e.g. for recognition and reconstruction. In the presence of noise, in general they do not obey the geometric conditions imposed by the projective imaging process. Under various optimality conditions, algorithms are presented for the correction of such line-drawings, disturbed

World War II at 24 Frames a Second : Scandinavian Examples

Historia förmedlas ofta på ett inflytelserikt sätt på film. I "World War II at 24 Frames a Second" jämförs filmiska representationer av andra världskriget i Danmark, Norge och Sverige med fokus på den senaste tioårsperioden.

Flint and Groundstone Axes in the Scanian Neolithic. An evaluation of raw materials based on experiment

One of the most common Neolithic tool types in Scandinavia which is available to us for study today is the axe. Judging by the thousands of such axes found in museum collections, this tool was an important part of Neolithic man's toolkit. While most of the axes which are considered primarily work axes (as opposed to the more ceremonial so-called battle axes) are made of flint, other, non-flint mat

Bleeding Oesophageal Varices. A Clinical Study of Mesocaval Interposition Shunting and Endoscopic Sclerotherapy

Popular Abstract in Swedish Blödande åderbråck i matstrupen - en jämförande studie mellan kirurgisk shunt och lokal behandling Patienter med skrumplever riskerar många komplikationer. Den mest fruktade är blödning från oesofagusvaricer, dvs åderbråck i matstrupen. Fyrtio procent av patienterna avlider om de inte får behandling. Anledningen till att patienter med skrumplever (cirros) utvecklar oesThis thesis is aimed at evaluating the clinical results of two treatments in patients with bleeding oesophageal varices; the mesocaval interposition shunt (MI shunt) and repeated endoscopic sclerotherapy (ST). 24 patients were randomised to MI shunt and 21 patients to the ST group (mean age 51.6?9.2 and 53.6?10.5 years). Complications include shunt occlusion in 4 %, oesophagitis in 33 % and oesoph

Multilinear Constraints in the Infinitesimal-time Case

In this paper we study the infinitesimal-time case of the so called multilinear constraints that exist for each subsequence in a sequence of images. These constraints link the infinitesimal motion of the image points with the infinitesimal viewer motion. The analysis is done both for calibrated and uncalibrated cameras. Two simplifications are also presented for the uncalibrated camera case. One s

Ischemic Tolerance and Cell Signaling in the Rat Brain

Popular Abstract in Swedish Cellulära mekanismer vid ischemisk tolerans Stroke, hjärntrauma, hjärnblödning och övergående hjärtstillestånd, leder till minskat blodflöde till hjärnan (ischemi) och orsakar hjärnskador. Mot denna skadeutveckling finns ännu inte något medel för kliniskt bruk. I djurexperimentella ischemimodeller har man kunnat skydda hjärnan mot ischemiska skador genom att utsätta hjäA brief period of sublethal ischemia in the brain induces resistance to a subsequent, otherwise lethal ischemic insult. This phenomenon is known as ischemic tolerance or preconditioning. A model of ischemic preconditioning in the rat brain using the two-vessel occlusion model of global cerebral ischemia was established. Using this model we have demonstrated that ischemic preconditioning protects t