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Cells synthesize proteins using 20 standard amino acids and expand their biochemical repertoire through intricate enzyme-mediated post-translational modifications (PTMs). PTMs can either be static and represent protein editing events or be dynamically regulated as a part of a cellular response to specific stimuli. Protein histidine methylation (Hme) was an elusive PTM for over 5 decades and has on

Background: Salivary mucin MUC5B seems to promote biodiversity in dental biofilms, and thereby oral health, for example, by inducing synergistic 'mucolytic' activities in a variety of microbial species that need to cooperate for the release of nutrients from the complex glycoprotein. Knowledge of how early colonizers interact with host salivary proteins is integral to better understand the maturat

#95. The Old Folks at Home, for solo voice (2016)TITLE: The Old Folks at HomeCAT# (YEAR COMPOSED): 95 (2016) INSTRUMENTATION: solo voicePAGES: 15DURATION (APPROX): 5’00PUBLICATION: BABELSCORES®

This chapter analyses volunteer work for identifying and reporting accessibility faults in urban settings. By looking closely at how people monitor adherence to the accessibility standards of laws and human rights, it is possible to recognise and understand their concrete fight against exclusion and discrimination. The author uses ethnographic data from go-alongs with two ‘accessibility detectives

Accessibility today has a contradictory character. One the one hand, people with disabilities are welcomed and included, with ambitious promises in policies and declarations. On the other hand, they are still excluded in everyday practices. This volume explores this contradiction in three areas: city and transport, knowledge and education, and law, institutions and history. Sweden is the primary cAccessibility today has a contradictory character. One the one hand, people with disabilities are welcomed and included, with ambitious promises in policies and declarations. On the other hand, they are still excluded in everyday practices. This volume explores this contradiction in three areas: city and transport, knowledge and education, and law, institutions and history. Sweden is the primary c

I show that the act-type theories of Soames and Hanks entail that every sentence with alternative analyses (including every atomic sentence with a polyadic predicate) is ambiguous, many of them massively so. I assume that act types directed toward distinct objects are themselves distinct, plus some standard semantic axioms, and infer that act-type theorists are committed to saying that ‘Mary loves

The paper proposes a way for adherents of Fregean, structured propositions to designate propositions and other complex senses/concepts using a special kind of functor. I consider some formulations from Peacocke's works and highlight certain problems that arise as we try to quantify over propositional constituents while referring to propositions using "that"-clauses. With the functor notation, by c

Semantic Dispositionalism is roughly the view that meaning a certain thing by a word, or possessing a certain concept, consists in being disposed to do something, e.g., infer a certain way. Its main problem is that it seems to have so many and disparate exceptions. People can fail to infer as required due to lack of logical acumen, intoxication, confusion, deviant theories, neural malfunctioning,

It is argued that although George Bealer's influential ‘Self-Consciousness argument’ refutes standard versions of reductive functionalism (RF), it fails to generalize in the way Bealer supposes. To wit, he presupposes that any version of RF must take the content of ‘pain’ to be the property of being in pain (and so on), which is expressly rejected in independently motivated versions of conceptual

I here defend a theory consisting of four claims about ‘property’ and properties, and argue that they form a coherent whole that can solve various serious problems. The claims are: (1) ‘property’ is defined by the principles (PR): ‘F-ness/Being F/etc. is a property of x iff F(x)’ and (PA): ‘F-ness/Being F/etc. is a property’; (2) the function of ‘property’ is to increase the expressive power of En

The article first rehearses three deflationary theories of reference, (1) disquotationalism, (2) propositionalism (Horwich), and (3) the anaphoric theory (Brandom), and raises a number of objections against them. It turns out that each corresponds to a closely related theory of truth, and that these are subject to analogous criticisms to a surprisingly high extent. I then present a theory of my ow

A new kind of defense of the Millian theory of names is given, which explains intuitive counter-examples as depending on pragmatic effects of the relevant sentences, by direct application of Grice’s and Sperber and Wilson’s Relevance Theory and uncontroversial assumptions. I begin by arguing that synonyms are always intersubstitutable, despite Mates’ considerations, and then apply the method to na

Aim: Studies have suggested that there is a difference in risk of local recurrence(LR) with circumferential resection margins (CRM) less than 1.0 mm. We aimed toexamine how exact resection margins affect LR risk.Method: Data from the Swedish Colorectal Cancer Registry (SCRCR) were usedfor retrospective analysis of resected rectal cancers between 2005 and 2013. Primaryendpoint was LR.Results: 12146

Background/Aim To evaluate circumferential resection margin(CRM) as a risk factor for distant metastasis (DM) in rectal cancer.The treatment of rectal cancer has evolved over the last decades.Surgical radicality is the single most important factor in preventingrecurrences, both locally and distantly. CRM B 1.0 mm is consideredto increase recurrence risk. However, not all patients with CRMB 1.0 mm

For two decades, Sébastien Tutenges has conducted research in bars, nightclubs, festivals, drug dens, nightlife resorts, and underground dance parties in a quest to answer a fundamental question: Why do people across cultures gather regularly to intoxicate themselves?Vivid and at times deeply personal, this book offers new insights into a wide variety of intoxicating experiences, from the intimate