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Complement factor D (FD) (adipsin), is an adipokine essential for the activation of the complement alternative pathway (AP), contributing to inflammation but also to metabolic homeostasis through C3a production. We investigated the metabolic regulation of Cfd expression in mouse models. A diet-induced model of insulin resistance reduced expression of key AP components, including adipose Cfd, hepat
Urocanate reductase (UrdA) is a bacterial enzyme that converts urocanic acid to imidazole propionate. Its catalytic residue Arg411 undergoes a large conformational change in the substrate-bound versus product-bound states. In contrast to previously studied cryo-conditions, the room-temperature X-ray data of UrdA presented here show that the occupancy distribution of Arg411 is affected by crystal c
BACKGROUND: Air pollution is a major public health concern, contributing to cardiovascular and respiratory diseases. One of the main pathways by which air pollution affects cardiovascular health is through dysregulation of the autonomic nervous system (ANS), which impairs cardiac control. Hydrotreated vegetable oil (HVO) is a renewable fuel with unknown toxicity in comparison to conventional diese
The issue of leaders’ influence has not received much attention in civil society studies, classical leadership literature on the voluntary sector and elite research. This article explores self-representations of the different kinds of status and influence among Italian third sector leaders. It is based on 35 interviews with the leaders of major Italian third sector organisations and on an analysis
Addressing sustainability challenges requires profound changes and transformations across all sectors, including tourism. Bound up in the operationalisation of transformation is the discursive aspects of change: the claims around how change can and should happen. This is a hitherto under-researched area, especially in sustainable tourism governance. This paper responds to this gap by investigating
Structural rearrangements have been shown to be important in local adaptation and speciation, but have been difficult to reliably identify and characterize in non-model species. Here we combine long reads, linked reads and optical mapping to characterize three divergent chromosome regions in the willow warbler Phylloscopus trochilus, of which two are associated with differences in migration and on
Proteins are useful chiral selectors. In order to understand the recognition mechanism and chiral discrimination, the binding of the (R)- and (S)-enantiomers of a series of designed amino alcohol inhibitors based on propranolol to cellobiohydrolase Cel7A (Trichoderma reesei) has been studied more closely. X-ray crystal structures were determined of the protein complex with the (R)- and (S)-enantio
Phase change heat storage is the backbone of energy storage technology, but its storage time is affected by the low thermal conductivity of phase change materials. Therefore, the melting performance of a triplex-tube latent heat thermal energy storage unit (T-LHTESU) in a phase change heat storage system is studied in this paper, and the rotation mechanism is applied to the unit. Firstly, a numeri
Importance: Chronic kidney disease (CKD) has been associated with increased plasma concentrations of phosphorylated tau (p-tau) 217 and p-tau181, which potentially decreases their usefulness in the diagnostic workup of Alzheimer disease (AD). Objective: To investigate associations of CKD with plasma ratios of p-tau217 and p-tau181 to the corresponding unphosphorylated peptides in AD. Design, Setti
This study is based on heat transfer and a two-dimensional MHD Walters’ liquid B flow containing copper nanoparticles driven by a stretching sheet in a porous medium. Mass transpiration and thermal radiation effects are considered. The set of partial differential equations affected by the Marangoni boundary condition is used. A nonlinear system of equations is solved to obtain the coupled ordinary
Image interpolation algorithms pervade many modern image processing and analysis applications. However, when their weighting schemes inefficiently generate very unrealistic estimates, they may negatively affect the performance of the end-user applications. Therefore, in this work, the author introduced four weighting schemes based on some geometric shapes for digital image interpolation operations
In this work, the best size for late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) images in the training dataset was determined to optimize deep learning training outcomes. Non-extra pixel and extra pixel interpolation algorithms were used to determine the new size of the LGE-MRI images. A novel strategy was introduced to handle interpolation masks and remove extra class labels in
In recent years, the Inter-American Court of Human Rights (“IACrtHR”) has developed an innovative jurisprudence that has reaffirmed and further developed the right of indigenous peoples as an integrative part of the corpus juris of the international human rights law (“ihrl”). In fact, through a dynamic, systemic, evolutive and effective interpretation of the American Convention on Human Rights (“a
Background: Optimal reconstruction of the perineal defect after extended abdominoperineal excision remains uncertain, and randomized comparisons between biological mesh and myocutaneous flaps are lacking. This trial assessed whether an acellular porcine collagen implant (APCI) is non-inferior to a gluteus maximus myocutaneous flap (GMF) for pelvic floor reconstruction. Methods: NEAPE was a multice
The modification of the electronic properties of CeO2 thin films through Cu doping is a promising approach to enhancing their performance in photoinduced water splitting (WS). In this study, undoped and Cu-doped CeO2 films of 5 nm thickness with 5 and 11% Cu atomic concentrations were characterized under ambient pressure conditions by near-edge X-ray absorption fine structure (NEXAFS) to provide i
This article examines the underexplored issue of public social protection in the artisanal and small-scale mining (ASM) sector. Social protection is defined as public actions taken in response to levels of vulnerability, risk, and deprivation considered socially unacceptable within a given society and polity. Drawing on a study of ASM in Rwanda, the article identifies a range of state-led policies
Hydrogen is a promising candidate to be the main renewable energy source in the future, but there has been limited development of hydrogen storage methods. PtxPd100−x (25 ≤ x ≤ 75) nanostructures composed of a mixture of nanofoams and nanoparticles are synthesized with a Pt-rich core and a Pd-rich shell atomic structure. We observed that the higher the amount of Pd, the higher the hydrogen uptake.
Bimetallic nanoparticles are promising catalysts that can improve performance in heterogeneous catalysis and solid-state electrochemistry. Exsolution is a useful method for forming such nanoparticles; however, it is limited by the elements present within the host oxide lattice. In this work, we develop and demonstrate a strategy to form bimetallic particles from La 0.5Sr 0.5Ti 0.94Ni 0.06O 3
