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An experimental and numerical study has been conducted to analyze the effects of rib configurations on heat transfer in U-turn rotating rectangular channels with smooth walls. A new model of a wavy rib is studied and compared with traditional ribs in a rectangular cross-section. Heat transfer coefficients for all rib configurations were measured from Reynolds numbers 4000 to 12000, whereas rotatio
Vascular smooth muscle cell plasticity plays a pivotal role in the pathophysiology of vascular diseases. Despite compelling evidence demonstrating the importance of transcription factor GATA6 in vascular smooth muscle, the functional role of GATA6 remains poorly understood. The aim of this study was to elucidate the role of GATA6 on cell migration and to gain insight into GATA6-sensitive genes in
During the first half of 2022, the World Health Organization reported an outbreak of acute severe hepatitis of unknown aetiology (AS-Hep-UA) in children, following initial alerts from the United Kingdom (UK) where a cluster of cases was first observed in previously well children aged <6 years. Sporadic cases were then reported across Europe and worldwide, although in most countries incidence did n
The correspondence between galaxy major mergers and starburst activity is well established observationally and in simulations of low-redshift galaxies. However, the evolution of the properties of interactions and of the galaxies involved suggests that the starburst response of galaxies to merger events could vary across cosmic time. Using the vintergatan cosmological zoom-in simulation of a Milky
The star formation history of a galaxy is modulated by a plethora of internal processes and environmental conditions. The details of how these evolve and couple together are not fully understood yet. In this work, we study the effects that galaxy mergers and morphological transformations have on setting different modes of star formation at galactic scales and across cosmic time. We monitor the glo
The focus of this study is threefold: (1) to examine how jaw displacement patterns vary with prosodic focus in American English, (2) to determine whether narrow focus induces greater jaw lowering than broad focus, and (3) to compare two different techniques for recording these jaw displacement patterns—Electromagnetic Articulography (EMA) and the new, innovative MARRYS helmet system. Simultaneous
Anxiety disorders are common in children and adolescents, but constrained resources limit access to cognitive-behavioral therapy (CBT). Stepped and stratified care models offer different ways to organize care. Stepped care starts with lower-resource CBT and escalates when needed, whereas stratified care matches CBT format to patient complexity from the outset. Economic evidence comparing these mod
Lake Titicaca in South America is highly sensitive to climatic variability, making it particularly vulnerable to climate change and raising concerns about long-term drying. Fluctuations in lake-water-levels (LWLs) can trigger cascading impacts across the downstream Titicaca-Desaguadero-Poopó-Salares (TDPS). This study evaluates the dependence of Lake Titicaca’s water level on air temperature and p
In the Swedish universal healthcare system, persons living with rare diseases (PLWRD) face major challenges in receiving diagnosis and accessing care,stemming in part from heterogeneity of disease and systemic barriers to care. This contributes to health inequity and a lack of visibility for PLWRD within thehealth system. This Perspective paper provides an overview of the facilitators and challeng
Reliable force estimation is essential for tool design, process stability, and adaptive control, yet direct force measurement is often impractical in production machining. This study presents a hybrid experimental-analytical framework for inverse identification of time-resolved cutting forces and process parameters during orthogonal cutting of compacted graphite iron under dry and minimum quantity
Background: Patient expectations are important psychological determinants of health outcomes. The Treatment Expectation Questionnaire (TEX-Q) is a validated, multidimensional instrument for assessing treatment expectations; however, no Danish version has previously been available. This study aimed to translate and conduct an initial psychometric evaluation of a Danish version of the TEX-Q in patie
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in Type 1 Diabetes (T1D), but a subset of individuals remains free from macrovascular or renal complications despite decades of hyperglycaemia and a significant risk factor burden. We used a targeted proteomic approach (Olink Cardiovascular panel III, targeting 92 proteins) to characterize the proteomic profile of cardiov
Monitoring suspended sediment concentration (SSC) is essential for water-quality management and for anticipating sediment-related impacts. Yet sparse in situ measurements limit tracking SSC at high temporal and spatial resolution. We address this gap with a scalable approach that couples multispectral imagery (Landsat-8/9, Sentinel-2), remote sensing precipitation product (CHIRPS), and soil proper
Complement factor D (FD) (adipsin), is an adipokine essential for the activation of the complement alternative pathway (AP), contributing to inflammation but also to metabolic homeostasis through C3a production. We investigated the metabolic regulation of Cfd expression in mouse models. A diet-induced model of insulin resistance reduced expression of key AP components, including adipose Cfd, hepat
Urocanate reductase (UrdA) is a bacterial enzyme that converts urocanic acid to imidazole propionate. Its catalytic residue Arg411 undergoes a large conformational change in the substrate-bound versus product-bound states. In contrast to previously studied cryo-conditions, the room-temperature X-ray data of UrdA presented here show that the occupancy distribution of Arg411 is affected by crystal c
