Sökresultat

Background: We aimed to determine corticosteroid (CS) use in paediatric inflammatory bowel disease (PIBD, < 18 years), which remains common despite recommendations for limited use and the emergence of steroid-sparing therapies. Methods: We conducted a study of all children in Sweden diagnosed with CD (n = 2460) or UC (n = 2470) in 2006–2022. Nationwide health registers provided annual individual-l

GOALS: To assess the incidence, type, and severity of infections in patients with IBD before and after starting thiopurine therapy.BACKGROUND: Thiopurines have been used for decades in the treatment of inflammatory bowel disease (IBD), yet real-world data regarding the extent and types of infections associated with their use are scarce.STUDY: We included all thiopurine-naive adults with IBD who in

ObjectivePediatric cancer patients are at increased risk for sleep disturbances; however, there are no clinical practice guidelines for treating sleep disturbances in pediatric oncology, resulting in variable approaches to sleep management across clinicians. The current study surveyed clinicians regarding their approaches to assessing and treating sleep.MethodsA total of 200 pediatric oncology cli

Daylight is crucial for the well-being of individuals in indoor environments, providing numerous physiological and psychological benefits. Achieving satisfactory daylight levels can be particularly challenging during adaptive reuse of existing buildings for new purposes. This study determined the feasibility of adapting an office for residential use by assessing interior daylight availability and

Background: We aimed to assess the risk of serious infections in patients with inflammatory bowel disease (IBD) exposed to different advanced therapies. Methods: We linked nationwide registers and compared rates of incident serious infections in patients with Crohn’s disease (CD) and ulcerative colitis (UC) exposed to medical therapies versus matched general population comparators during 2007-2023

This paper presents an initial technology assessment of the suitability of using aluminium as an energy carrier in shipping. The overall conclusion is that aluminium may become a suitable future energy carrier. Several advantages of using aluminium exist, including high theoretical energy densities, high resource availability, opportunity for circularity, and future potential for low lifecycle envThis paper presents an initial technology assessment of the suitability of using aluminium as an energy carrier in shipping. The overall conclusion is that aluminium may become a suitable future energy carrier. Several advantages of using aluminium exist, including high theoretical energy densities, high resource availability, opportunity for circularity, and future potential for low lifecycle env

OBJECTIVE: To examine temporal changes in late diagnosis of HIV (LD) among migrant and non-migrant people with HIV in Sweden 2003-2023 and to assess demographic and socioeconomic risk factors for LD in these two populations.METHODS: People with HIV diagnosed with HIV-1 in Sweden 2003-2023 were included (n = 6278). LD was defined as a first CD4+ T-cell count <350 cells/μL or an AIDS-defining event

a craft-participatory durational performance

Innate-like T cells (ILTCs) link innate immune responses with adaptive immune functions. This group includes invariant natural killer T (iNKT) cells, mucosa-associated invariant T (MAIT) cells, and γδ T cells. ILTCs detect transformed or stressed cells via non-classical antigen presentation pathways. For example, iNKT cells recognize CD1d-presented glycolipids, MAIT cells respond to MR1-presented

This keynote explores the borderlands of costume through the “corpo colectivo” (collective body) experiments (Lepecki 2017) initiated by Brazilian artist Lygia Clark (1920–1988) in the 1970s and Dutch textile artist Maria Blaisse’s (born 1944) ‘study of form and material possibilities’ (Marshall 2024, 144). These practices challenge conventional notions of costume offering ways to rethink costume

This brief summarizes expert knowledge on what really works to protect pollinators. To guide and assist national governments and other relevant governmental bodies in the endeavor to stop and reverse pollinator decline, this brief is intended for everyone interested in pollinator and nature restoration, from local practitioners to national and international governmental agencies.

Several ice-dammed lakes formed between the Younger Dryas moraines and the Tana River valley during the retreat of the Fennoscandian Ice Sheet over northeast Norway. Drainage of these lakes left an indelible scar on the landscape; the Gaccetávži ravine, a feature over 10 km long and up to 120 m deep. Here, we use LiDAR-derived digital terrain models, alongside field investigations and novel remote

Influenced by climate warming and sea-level rise, seacoasts in many parts of the world are undergoing regime shifts, including increased coastal erosion in the southeastern Baltic Sea. The aim of this study is to reconstruct the depositional and erosional history of the Järve coastal scarp using sediment stratigraphy, new luminescence and radiocarbon dates, ground-penetrating radar, and LiDAR data

We obtained 420 high-resolution spectra of Proxima, over 159 nights, using the Near Infra Red Planet Searcher (NIRPS). We derived 149 nightly binned radial velocity measurements with a standard deviation of 1.69 m s−1 and a median uncertainty of 55 cm s−1, and performed a joint analysis combining radial velocities, spectroscopic activity indicators, and ground-based photometry, to model the planet