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In the present study, we characterize the binding of divalent cations to insulin in aqueous salt solutions by means of capillary electrophoresis and molecular dynamics simulations. The results show a strong pH dependence. At low pH, at which all the carboxylate groups are protonated and the protein has an overall positive charge, all the cations exhibit only weak and rather unspecific interactions
Human exposure to radio frequency (RF) electromagnetic fields should not exceed the exposure limits set by the relevant regulatory guidelines. In this paper, we provide approaches to determine upper bounds of maximum exposure from multiple antennas. When the total transmitted power is fixed, the maximum exposure can be determined by an eigenvalue decomposition. If an individual antenna has additio
Feedforward control schemes to compensate for disturbances are very well known in process control. In those control approaches, PID controllers are usually considered in the feedback loop, where nominal design for both feedback and feedforward controllers are commonly performed. This paper presents a robustness analysis to study how uncertainties can affect the classical feedforward control scheme
Timescale uncertainties between paleoclimate reconstructions often inhibit studying the exact timing, spatial expression and driving mechanisms of climate variations. Detecting and aligning the globally common cosmogenic radionuclide production signal via a curve fitting method provides a tool for the quasi-continuous synchronization of paleoclimate archives. In this study, we apply this approach
This paper proposes a simple and improved approach of estimating MIMO capacity from antenna magnitude patterns, i.e., the antenna patterns are phaseless. The simple approach synthesizes the phases according to the antenna spacing, and it compares favorably with an existing approach based on random phase synthesis. Moreover, the simple approach can be improved by taking into account the correlation
We discuss in this paper the relevance of the territorial scalar approach in the analysis of biodiversity conservation and natural resource exploitation. We do this by using an empirical case study focused on the use of the forest ecosystems by diverse stakeholders in Korup region, South West Cameroon.Our aim is to contextualize biodiversity conservation in Korup National Park in a larger territor
The effective use of multiple antenna systems in compact terminal devices is plagued by the problems of mutual coupling and spatial correlation. Consequently, increasing the number of antennas per unit volume results in rapidly diminishing returns after an upper limit is reached. We review recent advances on this topic of closely coupled antennas, including several existing techniques that may be
Background: Controversy exists as to the health effects of exposure to asphalt and crumb rubber modified (CRM) asphalt, which contains recycled rubber tyres. Objective: To assess exposures and effects on airway symptoms, lung function and inflammation biomarkers in conventional and CRM asphalt road pavers. Methods: 116 conventional asphalt workers, 51 CRM asphalt workers and 100 controls were inve
In the last century, starch present in foods was considered to be completely digested. However, during the 1980s, studies on starch digestion started to show that besides digestible starch, which could be rapidly ors lowly hydrolysed, there was a variable fraction that resisted hydrolysis by digestive enzymes. That fraction was named resistant starch (RS )and it encompasses those forms of starch t
Background: Perioperative complications can affect outcomes after gastrectomy for cancer, with high mortality and morbidity rates ranging between 10 and 40%. The absence of a standardized system for recording complications generates wide variation in evaluating their impacts on outcomes and hinders proposals of quality-improvement projects. The aim of this study was to provide a list of defined ga
Background: Although low birthweight (LBW) babies represent only 15.5% of global births, it is the leading underlying cause of deaths among newborns in countries where neonatal mortality rates are high. In Uganda, like many other sub-Saharan African countries, the progress of reducing neonatal mortality has been slow and the contribution of low birthweight to neonatal deaths over time is unclear.
Background: In recent years, our group has developed electro-optical remote sensing methods for the monitoring and classification of aerofauna. These methods include active lidar methods and passive, so-called dark-field methods that measure scattered sunlight. In comparison with satellite- and airborne remote sensing, our methods offer a spatiotemporal resolution several orders of magnitude highe
Climate change and variability are likely to increase in most parts of the world, leading to more extreme events, which may increase the stress on already threatened water resources. This study focuses on the effects of the El Niño Southern Oscillation in the rainfall of Pucara basin and in the groundwater levels of the Punata alluvial fan in the Bolivian sub-Andes. Climate change and variability
We examine the effect of birth weight on health throughout childhood, adolescence, and early adulthood, focusing on two health outcomes: all-cause and cause-specific hospitalizations and sickness absences. The outcomes are important, not only from a health perspective but also from a labor market perspective, as the inability to fully participate in the labor force due to impaired health is known
The analysis of aggregates of therapeutic proteins is crucial in order to ensure efficacy and patient safety. Typically, the analysis is performed in the finished formulation to ensure that aggregates are not present. An important question is, however, what happens to therapeutic proteins, with regard to oligomerization and aggregation, after they have been administrated (i.e., in the blood). In t
BACKGROUND: Acute myocardial infarct (AMI) size depicted by late gadolinium enhancement cardiovascular magnetic resonance (CMR) is increasingly used as an efficacy endpoint in randomized trials comparing AMI therapies. Infarct size is quantified using manual planimetry (MANUAL), visual scoring (VISUAL), or automated techniques using signal-intensity thresholding (AUTO). Although AUTO is considered
Expression of fat mass and obesity-associated gene (FTO) and ADP-ribosylation factor-like 15 (ARL15) in human islets is inversely correlated with HbA1c. However, their impact on insulin secretion is still ambiguous. Here in, we investigated the role of FTO and ARL15 using GRINCH (Glucose-Responsive Insulin-secreting C-peptide-modified Human proinsulin) clonal rat β-cells. GRINCH cells have inserte
The overall objective of this thematic session is to present new research and discuss how different cultures and communities sense the world by paying attention to one of its more accessible manifestations: language. We bring together scholars who work on various aspects of how sensory perceptions are verbally manifested and use different methodologies, from experimental to discourse-based. The ge
