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Objective: We investigated the association between maternal use of vitamin D and omega-3 fatty acids (n-3 FAs) supplements during pregnancy and risk of islet autoimmunity (IA) in the offspring. Methods: The Environmental Determinants of Diabetes in the Young (TEDDY) Study is prospectively following 8676 children with increased genetic risk for type 1 diabetes in Finland, Germany, Sweden, and the U
Timber-concrete composite structures (TCCs) are widely gaining interest in Europe and America, because of its high strength and low energy-consumption structure. The key design point of timber-concrete composite structures are to ensure the reliability of the shear connectors. The objective of this paper was to predict structural response with finite element (FE) analysis and provide shear propert
Stroke is a life threatening medical condition that is caused either by a blood clot or a bleeding inside the brain. It is generally agreed that immediate treatment of stroke patients is crucial for their ability to recover; however, before treatment can be initiated, the stroke patient has to be diagnosed using, for example, a computed tomography scan of the brain. This, in turn, requires that th
The TRE3 research project focuses on the development of a new and innovative timber frame wall modulus for emergency housing facilities. The wall modulus, in this paper referred to as Hybrid Timber Frame (HTF) wall system, is an evolution of the traditional Light-Frame Timber (LFT) structural systems and combines the advantages and some peculiar aspects of lightweight structures to the potentialit
Background Deaths of despair (DoD)—comprising suicide, drug-related, and alcohol-related deaths— have been linked to recent slowdowns in life expectancy (LE) in the USA, but comparative cross-national evidence on their contributions to LE changes across Europe remains limited. This study quantified the age- and cause-specific contributions of DoD to changes in LE at birth across European countries
PURPOSE: Compare the radiological characteristics of screening images preceding interval cancers that occurred in women screened with digital breast tomosynthesis (DBT) plus digital mammography (DM) vs. those in women screened with DM alone.MATERIALS AND METHODS: From two randomized trials comparing DBT + DM vs. DM, 91 (43 from DBT + DM arm and 48 from DM arm) images preceding interval cancers and
We report a comprehensive characterization of the multi-layered flame structure of a burning aluminum (Al) droplet in steam, using a novel spatiotemporally resolved laser absorption imaging technique combined with detailed numerical simulations. Spatial distributions of Al vapor mole fraction in the near-surface region (r/R0 < 1.2, R0: droplet radius) are quantified by accounting for resonance bro
Aluminum combustion in steam offers a promising route for recyclable, zero-carbon cogeneration of heat and hydrogen. However, the development and validation of mechanisms and models for micron-sized Al droplet combustion is limited by the scarcity of quantitative, high spatiotemporal resolution experimental data. We combine high-speed microscopy with laser absorption imaging tomography to quantita
Towards high-efficiency energy conversion using bulk aluminum, this work presents an investigation on the generation, ignition, and combustion of molten aluminum sprays. A novel dual-gas atomization method integrated with inductive heating was developed to produce aluminum sprays at pressures below 0.5 MPa, yielding droplets with a mean size of 180 µm. Finer droplets within the spray were successf
This is the first nationwide real-world register-based family study of factor V Leiden (FVL). To determine number of diagnosed patients with FVL in Sweden and the associated risk for venous thromboembolism (VTE). The Swedish Multi-Generation Register was linked to the Swedish National patient register for the period 1964–2018. Patients with FVL (FVL heterozygotes or homozygotes) were linked to fam
INTRODUCTION: Central venous catheter (CVC) insertion is frequently required in patients with haematological diseases. Despite limited evidence, thrombocytopenia often prompts prophylactic platelet transfusion before catheterisation.METHODS: We conducted an observational before-and-after study including the first non-tunnelled CVC insertion performed in adult patients with haematological diseases
Spatial omics allows for comprehensive investigation of the tumor immune microenvironment (TIME). Stratifying patients by their TIMEs contributes with insights in tumor immune response and has the potential to guide treatment decision-making in the immuno-oncology setting. However, high-plex spatial omics approaches still suffer from high costs and limited direct clinical applicability. We address
Lifestyle interventions tend to reduce disordered eating short-term in children, but little is known about long-term changes. This study aimed to investigate changes in appetitive traits and episodes of overeating and binge-eating up to three years after a 10-week multicomponent lifestyle camp in 7–14-year-olds. Participants were referred to the lifestyle camp due to overweight/obesity, and/or psy
In the philosophical literature, it is often assumed that disinformation leads to false beliefs. However, empirical work in the social sciences has established that much disinformation rather creates uncertainty. Taking seriously these empirical findings, I develop a non-doxastic theory of disinformation which I call the “live possibility model”. The core claim of my theory is that disinformation
Background: Offering care and support to survivors of sexual violence is crucial in order to support their healing and recovery. Yet, accessing care is often challenging for survivors and especially in humanitarian settings. North Kivu, a province in the eastern part of the Democratic Republic of the Congo, has been ravaged by conflict and violence for several decades and is one of the worst human
