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Transient Receptor Potential Ankyrin 1 (TRPA1) is a nonspecific cation channel activated by a wide range of stimuli. The polymodal receptor resides in the cell membrane of sensory neurons and plays a key role in nociceptive pain transmission. Environmental irritants such as allyl isothiocyanate, an electrophile found in wasabi, activate TRPA1. In this work, the goal was to lay the basis for struct
