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Objective: To determine the incidence and clinical significance of neutralizing antibody (NAb) formation in patients with relapsing multiple sclerosis ( MS) who participated in the European Interferon Beta-1a IM Dose-Comparison Study. Methods. Patients were randomized to treatment with interferon beta-1a (IFN beta-1a) 30 mu g or 60 mu g IM once weekly for up to 4 years. Serum samples obtained at b
In intact rabbit femoral artery rings pre-contracted with phenylephrine, acetylcholine (ACh; 10(-9)-10(-6) M) produces endothelium-dependent relaxation, abolished after mechanical rubbing to remove the endothelium. The response to ACh was absent at low oxygen tension (less than or equal to 4 kPa) or in the presence of sodium cyanide (1 mM). Intact rabbit jugular veins relaxed to ACh in lower conce
Multi-electrode geoelectrical imaging has become very popular and is used for many different purposes. For some of these, the inclusion of IP data would be desirable as it would allow the interpreter to distinguish between, e.g. sand formations with saltwater infiltration and clay formations or help delineate landfills. However, present-day IP measuring techniques require the use of nonpolarisable
Denna ovanligt intressanta, tvärvetenskapliga konferensvolym innehåller 13 bidrag från olika discipliner, länder och perspektiv. Den bygger på bidrag vid en konferens i Paris 1997, som utgick från skillnaden mellan Christendom och Christianity: ”Christendom is a civilisation in which (a) Christianity is the dominant religion and (b) this dominance has been backed up by social or legal compulsions”
Moisturizing creams have beneficial effects in the treatment of dry, scaly skin, but they may induce adverse skin reactions. In a randomized double-blind study, 197 patients with atopic dermatitis were treated with one of the following: a new moisturizing cream with 20% glycerin, its cream base without glycerin as placebo, or a cream with 4% urea and 4% sodium chloride. The patients were asked to
Two climate model simulations made with the Rossby Centre regional Atmospheric model version I (RCA1) are evaluated for the precipitation climate in Scania, southern-most Sweden. These simulations are driven by the HadCM2 and the ECHAM4/OPYC3 global circulation models (GCMs) for 10 years. Output from the global and the regional simulations are compared with an observational data set, constructed f
Fluorescence blinking behaviour was observed for single molecules of the conjugated polymer poly[2-methoxy,5-(2'-ethylhexyloxy)-p-phenylene-vinylene] (MEH-PPV) at 77 and 300 K. No strict qualitative dependence on temperature was observed, despite of the expected suppression of exciton migration at the low temperature. We assume MEH-PPV molecules to form dense nanoparticles with a characteristic si
Flow cytometry provides accurate relative cellular quantitation (percent abundance) of cells from diverse samples, but technical limitations of most flow cytometers preclude accurate absolute quantitation. Several quantitation standards are now commercially available which, when added to samples, permit absolute quantitation of CD4+ T cells. However, these reagents are limited by their cost, techn
Charge state distributions for (12) C and C-13 ions have been measured at the Lund Pelletron tandem accelerator for the N-2 gas stripper with a newly installed terminal pumping system in use. A comparison of the results obtained for the ion energies between 1.5 and 2.8 MeV with the foil stripper and the gas stripper without terminal pumping demonstrates the great improvement of the stripping proce
An anti-estradiol antibody with improved specificity is searched for by combining steroid analog binding studies, mutant antibodies obtained from a phage-display library and structural modeling. Three-dimensional models for the anti-estradiol antibody 57-2 were constructed by comparative model building. Estradiol and analogs were docked into the combining site and molecular dynamics simulation was
The overall aim of this thesis was to investigate families’ experiences when a child is diagnosed as having type 1 diabetes, and at one and three years after diagnosis. Since childhood health and the circumstances around it in the family have been shown to have a lasting impact on adult health and circumstances, an additional aim was to examine the long-term effect of childhood diabetes on educati
Popular Abstract in Swedish Tidstrender i prevalens, incidens och mortalitet följdes för 15000 diabetespatienter under 1991-2005. Kliniska fynd, C-peptidanalyser och öcellsantikroppar jämfördes med avseende på förmågan att särskilja typ 1 från typ 2 diabetes och faktorer som påverkade prognosen undersöktes. Incidens och ålder vid insjuknandet förhöll sig oförändrade över tid, men prevalensen ökadTime trends in prevalence, incidence and mortality was followed in 15000 diabetic patients in 1991?2005. Clinical findings, C-peptide protocols, and islet antibodies were compared in their ability to distinguish type 1 from type 2 diabetes, and factors associated with the prognosis of diabetes were explored. The incidence and the age at onset remained stable but the prevalence of diabetes increas
Our aim was to describe voluntary associations for patients with cancer in Sweden (n=108) and their activities, type and extent of member support, and the associations' collaboration with the health care system. A specially constructed questionnaire with structured and open questions was used for the investigation. The frequency of answers was 89%. The results show in the broadest sense that the a
Effects of hypoxia and glucose-free solution on the isolated rat portal vein were studied. Decrease of extracellular PO2 below 50 mm Hg caused graded inhibition of spontaneous mechanical activity; below 7 mm Hg, inhibition was complete in most preparations. Contracture force of depolarized portal vein was less sensitive to decreases in PO2. Responses to noradrenaline at all concentrations were mar
Allergy and autoimmunity are both examples of deregulated immunity characterized by inflammation and injury of targeted tissues that have until recently been considered disparate disease processes. However, recent findings have implicated mast cells, in coordination with granulocytes and other immune effector cells, in the pathology of these two disorders. The BioBreeding (BB) DRlyp/lyp rat develo
