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The aim of this study was to evaluate the possibility of decreasing the myelotoxicity associated with radioimmunotherapy (RIT) by extracorporeal depletion of radioimmunoconjugates (RIC) from the circulation. The optimal combination of radionuclide and the time interval between injection of the RIC and the subsequent extracorporeal depletion procedure was assessed in immunocompetent rats, with resp

Patterns of polyploid evolution in the taxonomically controversial Dactylorhiza incarnata/maculata groups were inferred genetically by analyzing 399 individuals from 177 localities for (1) four polymorphic plastid regions yielding aggregate haplotypes and (2) nuclear ribosomal ITS allele frequencies. Concordance between patterns observed in distributions of plastid haplotypes and ITS alleles rende

Popular Abstract in Swedish I denna avhandlig undersöks hur mekanisk sträckning påverkar den glatta muskulaturen som omger våra blodkärl. En ökad sträckning av blodkärlen sker till exempel vid högt blodtryck vilket leder till en förändrad struktur av kärlet, så kallad remodellering. Ett annat mekaniskt stimuli utgörs av blodets friktion mot de endotelceller som täcker blodkärlens kontaktyta mot blThe vascular wall has a remarkable capacity to adapt to mechanical forces exerted by the intraluminal blood pressure and flow. This includes rapid change in contractile tone as well as chronic alteration of vessel structure if the stimulus persists. Stretch of the intact blood vessel wall promotes growth and contractile differentiation. The molecular mechanisms involved are not well defined, but c

Popular Abstract in Swedish För att pröva om värdering av kvalitet i kollektivtrafik med Stated Preferences-metoden kan göras i brevenkäter skickades olika enkäter ut till i förväg kontaktade bussresenärer. Studien visar att metoden kan användas i brev och att typen med parvisa val i så fall bör användas. En annan studie visar att erfarenheten av det man värderar har stor betydelse för värderingenTo test whether it was possible to conduct a Stated Preference study by mail, six different types of questionnaires were sent out to previously contacted bus passengers. Several quality comparisons showed that binary choices worked best. Another study showed that the experiences of travellers are of great importance to their evaluations.

En undersökning av vittnesbördsteologin i den johanneiska skriftgruppen

In May 2003 Lund University, Sweden, ordered a new AMS facility from National Electrostatics Corp. (NEC), Wisconsin. The system is the first low energy, open air, single stage AMS system (SSAMS). The machine is equipped with a dual ion source sequential injector, which allows measurements of carbon with the masses 12, 13 and 14. The machine operates at 250 kV with the gas stripper, high energy mag

Unicompartmental knee arthroplasty (UKA) is known to have a higher risk of revision than tricompartmental arthroplasty (TKA), while UKA implants are generally less expensive than TKA implants. We estimated the costs of implants and hospital stay of both procedures and related the cost difference at primary operation to the difference in number of revisions to be expected. We compared 15,437 primar

A dosing strategy for the transient control of an exhaust after-treatment system using the NOx storage and reduction approach was developed on a heavy-duty diesel engine rig equipped with an I I I diesel engine. The catalysts were oxidation catalysts of 8.41 and NOx storage and reduction catalysts of 16.8 1 total volume. The dosing strategy has been tested in a European Transient Cycle (ETC) resul

Popular Abstract in Swedish Denna avhandling behandlar matematik, finans och dator simuleringar. I matematiska termer handlar den om tillämpad sannolikhetsteori och från ett finansiellt perspektiv handlar den om derivatprissättning. Avhandlingen är organiserad som följer. De två första kapitlen presenterar derivatprissättning och levy processer. Kapitel 3 beskriver och undersöker en simulerings mThis thesis contributes to mathematics, finance and computer simulations. In terms of mathematics this thesis concerns applied probability and Lévy processes and from the financial point of view the thesis concerns derivative pricing. Within these two areas several simulation techniques are investigated. The thesis is organized as follows. The first two chapters are to be considered as reviews on

Sequential CAT scan studies of the brain were performed in a 7-year-old boy with Listeria monocytogenes serotype 1 meningoencephalitis. The infection occurred while he was receiving maintenance chemotherapy for T-cell non-Hodgkin lymphoma. A lesion in the right hemisphere during the infection resulted in an excessive enlargement of the right ventricle 10 months later, most probably caused by arter

The new questionnaire Euroquest was designed to study effects from exposure to organic solvents, and it covers the most commonly reported symptoms associated with long-term solvent exposure. Its convergence and criterion validity were evaluated by means of comparison with the two well-established generic symptom questionnaires Symptom Checklist (SCL-90) and General Health Questionnaire (GHQ-30). M

Popular Abstract in Swedish Den viktigaste uppgiften inom den kliniska cytologin är att påvisa cancerceller i olika typer av cellprover. Många olika cancertumörer sprider sig till lungsäcken och bukhålan och ger då ofta upphov till vätska (exsudat) som innehåller cancerceller. Ofta kan cancerdiagnosen ställas på grundval av cellernas utseende men detta är inte alltid möjligt, eftersom cancercellerClinical cytology is a rapid method to detect malignancy in effusions of the serous cavities, but the morphological characteristics of the cells do not always allow diagnosis and a specific marker for malignant cells would improve the diagnostic performance. Telomerase adds telomere repeats to the chromosome ends. It is the most promising universal indicator of malignancy and the project focuses o

Recycling of the mu opioid receptor to the plasma membrane after endocytosis promotes rapid resensitization of signal transduction, whereas targeting of the delta opioid receptor (DOR) to lysosomes causes proteolytic down-regulation. We identified a protein that binds preferentially to the cytoplasmic tail of the DOR as a candidate heterotrimeric GTP-binding protein (G protein)-coupled receptor-as

To evaluate pain relief in a lumbar orthosis as a predictor for good clinical results after solid fusion, all patients scheduled for such a surgical procedure were preoperatively encouraged to use an orthosis, soft or rigid, for 3 weeks. Grade of back pain relief as a percent using the orthosis was assessed by the patients and was registered before surgery. After surgery, at 1-year follow-up, pati

Multipotent self-renewing hematopoietic stem cells (HSCs) are responsible for reconstitution of all blood cell lineages. Whereas growth stimulatory cytokines have been demonstrated to promote HSC self-renewal, the potential role of negative regulators remains elusive. Receptors for tumor necrosis factor (TNF) and Fas ligand have been implicated as regulators of steady-state hematopoiesis, and if o

Laser-induced fluorescence has been used for the identification of brain tumours in rats, which have been previously given tumour-seeking haematoporphyrin derivative. A pulsed nitrogen laser (λ=337 nm) was used in conjunction with an optical multichannel analyzer. For both inoculated RG-2 and TCVC rat-brain-tumour models, the blue autofluorescence was strongly reduced in the tumour compared with