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Pyocyanin, a redox-active secondary metabolite produced by Pseudomonas aeruginosa, serves as a crucial virulence factor. Detection and quantification of pyocyanin can aid early diagnosis of infection. A selective and sensitive molecularly imprinted electrochemical sensor was constructed by using a green polymerization technique to deposit an ultrathin polydopamine film on an electrode modified wit
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peer-reviewed introduction article for Special Issue: Refugees and Bureaucratic Violence.Refuge: Canada’s Journal on Refugees 39 (2).https://refuge.journals.yorku.ca/index.php/refuge/issue/view/2331
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This study considers deployable structures and presents a novel optimization method that aims to improve the stiffness at the fully deployed state. The considered structures consist of curved beams that deploy through buckling when rotated. The optimization aims to maximize the structural tangent stiffness by modifying the shape of the beam elements. To accurately predict the deformation, Finite E
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Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. However, target identification warrants a better understanding of the surfaceome and how it is modulated by the tumor microenvironment. Here, we decode the surfaceome and endocytome and its remodeling by hypoxic stress in glioblastoma (GBM
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In the current work, we present a topology optimization framework for designing periodic microstructures with viscoplastic constitutive behavior under finite deformation. Materials with tailored macroscopic mechanical properties, i.e. maximum viscoplastic energy absorp- tion and prescribed Poisson's ratio, are designed by performing numerical tests of a single unit cell subjected to periodic bound
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A hierarchical multiscale model that couples a region of material described by discrete dislocation plasticity1 to a surrounding region described by conventional crystal plasticity is presented. The coupled model captures size-dependent plasticity phenomena, such as dislocation structuring and formation of geometrically necessary dislocations, that can occur at the micron scale while also capturin