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Chemical building blocks for plastics can be produced from renewable biomass feedstocks using microbial production organisms, such as yeast or bacteria, in a biorefinery. One class of chemical building blocks that are suitable for production of biobased and biodegradable plastics are dicarboxylic acids, e.g. succinic acid. In order to avoid competition with food and feed production it is desirable
Background: Severe Alpha-1-Antitrypsin deficiency (AATD), phenotype PiZZ, is a leading cause of liver disease in neonates, children, and adults. Nevertheless, the prevalence of liver disease and mortality within PiZZ adults remains unclear. Between 1972 and 1974, a cohort of 129 individuals with severe AATD (PiZZ) was identified through the Swedish national screening of 200,000 newborns. The cohor
Bridges are an important part of the traffic infrastructure, which are subjected to high safety requirements and economic consequences in case of functionality failure. Therefore, it is needed to consider potentially substantial direct and indirect risks during service life, i.e., the need for risk and robustness analyses. Over the last decades, various quantitative performance criteria have been
There is an ever-increasing demand for structural metals with higher strength. Metals can be strengthened by reducing grain size in their microstructure, but ductility is also concomitantly reduced. High strength and ductility are a desirable combination of properties for most structural engineering materials. By arranging fine grains in a continuous network that surrounds islands of coarse grains
För snart ett decennium sedan startade en intensiv debatt om flygets klimatpåverkani svenska medier. I dess kölvatten har en social rörelse för minskat flygresande tagitform – flygfrittrörelsen. Den består av individer och organisationer som tillsammansengagerar sig för minskat flygresande, dels genom att delta i kampanjer och annatpåverkansarbete, och dels genom att själva avstå flygresande.Min aThe need for demand-side climate solutions is increasingly recognized in science and society. Such solutions imply that demand for goods and services is targeted either via changes in the use of infrastructure and technology or via cultural changes in consumption and lifestyle among the global affluent. In this thesis, I explore how to enable cultural change around affluent overconsumption through
Bacteriophages vB_YpeM_fEV-1 (fEV-1) and vB_YpeM_fD1 (fD1) were isolated from incoming sewage water samples in Turku, Finland, using Yersinia pestis strains EV76 and KIM D27 as enrichment hosts, respectively. Genomic analysis and transmission electron microscopy established that fEV-1 is a novel type of dwarf myovirus, while fD1 is a T4-like myovirus. The genome sizes are 38 and 167 kb, respective
Purpose – The aim of this paper is to contribute with increased knowledge of the complex role of internal communication during a crisis like the COVID-19 pandemic. More specifically, the authors want to address the following research questions. How can the overall approach to internal crisis communication during the pandemic be interpreted, and what view of internal crisis communication does this
This report describes a system model for assessing and updating the condition state and reliability of bridge structures utilizing inspection and monitoring data. The system model was developed on the basis of an existing continuous single-cell prestressed concrete box girder. The system model consists of two integrated sub-models: a condition model for predicting the deterioration state of the bo
Subcellular membrane systems are highly enriched in dolichol, whose role in organelle homeostasis and endosomal-lysosomal pathway remains largely unclear besides being involved in protein glycosylation. DHDDS encodes for the catalytic subunit (DHDDS) of the enzyme cis-prenyltransferase (cis-PTase), involved in dolichol biosynthesis and dolichol-dependent protein glycosylation in the endoplasmic re
New Findings: What is the central question of this study? What are the temporal responses of mitochondrial respiration and mitochondrial responsivity to insulin in soleus muscle fibres from mice during the development of obesity and insulin resistance? What is the main finding and its importance? Short- and long-term feeding with a high-fat diet markedly reduced soleus mitochondrial respiration an
