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Glutathione S-transferase alpha 4 prevents dopamine neurodegeneration in a rat alpha-synuclein model of Parkinson's disease

Parkinson's disease (PD) is a common, progressive neurodegenerative disease, which typically presents itself with a range of motor symptoms, like resting tremor, bradykinesia, and rigidity, but also non-motor symptoms such as fatigue, constipation, and sleep disturbance. Neuropathologically, PD is characterized by loss of dopaminergic cells in the substantia nigra pars compacta (SNpc) and Lewy bod

Superparamagnetic iron oxide nanoparticles (SPIONs) as a multimodality imaging probe for sentinel nodes : Design and Preclinical Evaluation

Bröst- och hudcancerceller sprider sig via lymfatiska systemet och fastnar i en eller två regionala sentinel lymfnoder (SLN) där de med stor sannolikhet växer till metastaser. Därför är SLN-biopsier och relaterade histopatologiska undersökningar viktiga vid cancerdiagnostiken för att bestämma sjukdomsstatus och att från denna kunna bestämma rätt behandling. Patienter vars lymfnoder innehåller spriBreast cancer and malignant melanoma disseminate through the lymphatic system and the first metastases arise in one or two regional, sentinel lymph nodes (SLNs) draining the primary tumour site. Therefore, identification and characterization of the SLNs is of major importance for cancer staging and for choice of therapy in patients. The standard clinical procedure relies on lymphoscintigraphy afte

Stop-and-Go Controller for Adaptive Cruise Control

In the field of vehicle control, conventional cruise control systems have been available on the market for many years. During the last years, modern cars include more and more electronic systems. These systems are often governed by a computer or a network of computers programmed with powerful software. One of those new services is adaptive cruise control (ACC) (or autonomous intelligent cruise con

Istanbul Contested: Redrawing Religious/Secular Boundaries in Turkish Visual Politics

This paper discusses the increasing prominence of religious, iconic symbolism in Turkish visual politics, by focusing state sponsored expositions, cultural-cum-pedagogic events and public celebrations, orchestrated by the Turkish AKP Government and affiliated municipalities. Such public, religio-cultural and populist orchestrations of Islamic symbolism, this paper argues, are aspects of a current

Potential use of biomass for separation of lignin by hydrotropic extraction

The demand for energy in the world is increasing steadily. As the standard of living for people in the developing countries is increasing so is the net energy use per capita. The main contributor to the energy consumption is the use of fossil fuels, which is also the major emission source for carbon dioxide. Carbon dioxide is in turn one of the most significant greenhouse gases and will enhance te

Optimization of breast tomosynthesis: Computer simulations of image acquisition and glandular dose

Breast tomosynthesis (BT) is an X-ray imaging technique recently introduced as an alternative or complement to standard digital mammography (DM) in breast imaging and breast cancer screening. In BT, a set of projection images is acquired over a limited angular range and reconstructed into a volume of slice images. The method includes many possible combinations of acquisition parameters that have t

How proteins modify water dynamics

Much of biology happens at the protein-water interface, so all dynamical processes in this region are of fundamental importance. Local structural fluctuations in the hydration layer can be probed by 17O magnetic relaxation dispersion (MRD), which, at high frequencies, measures the integral of a biaxial rotational time correlation function (TCF) - the integral rotational correlation time. Numerous

Seeking explanations for recent changes in abundance of wintering Eurasian Wigeon (Anas penelope) in northwest Europe

We analysed annual changes in abundance of Eurasian Wigeon (Anas penelope) derived from mid-winter International Waterbird Census data throughout its northwest European flyway since 1988 using log-linear Poisson regression modelling. Increases in abundance in the north and east of the wintering range (Norway, Sweden, Denmark, Germany, Switzerland), stable numbers in the central range (Belgium, Net

Temporal development of ozone within the Arctic Vortex during the winter of 1991/92

In this study we address the question of temporal ozone trends on isentropic surfaces within the Arctic polar vortex during EASOE. We have combined ozone sonde data from twelve campaign stations distributed throughout the European sector of the Arctic. The development of ozone at the 425, 475, 550 and 700K levels is presented, using analysed fields of isentropic potential vorticity and isentropic