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Recombinant factor IX Fc for the treatment of hemophilia B

Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E

Capital switching, economic crisis, and land rent : Examining discontinuation of Swedish municipal site leasehold in the 1980s

Harvey's capital switching thesis is one of the most influential contributions of Marxist geographers, providing a framework for understanding structural determinants of capital flows into urban land and built environments. Harvey's thesis has drawn criticism in subsequent debates for its lack of direct empirical support. Even decades later, several gaps remain. The most comprehensive intervention

Intraspecific variations of Dekkera/Brettanomyces bruxellensis genome studied by capillary electrophoresis separation of the intron splice site profiles

In enology, "Brett" character refers to the wine spoilage caused by the yeast Dekkera/Brettanomyces bruxellensis and its production of volatile phenolic off-flavours. However, the spoilage potential of this yeast is strain-dependent. Therefore, a rapid and reliable recognition at the strain level is a key point to avoid serious economic losses. The present work provides an operative tool to assess

Resistivity and Surface Wave Seismic Surveys in Geotechnical Site Investigations

Popular Abstract in Swedish Anpassningen av geofysiska metoder till infrastrukturtillämpningar är en viktig del i utvecklingen av geoteknisk förundersökningsmetodik. Det som här benämns geotekniska förundersökningar hänvisar till alla undersökningar som görs före eller under konstruktion, alltså sådana som syftar till att stödja och förbättra en konceptuell geologisk modell så väl som sådana som s

A multi-criteria GIS analysis for siting of utility-scale photovoltaic solar plants in county Kilkenny, Ireland

A novel broad-spectrum elastase-like serine protease from the predatory bacterium bdellovibrio bacteriovorus facilitates elucidation of site-specific IgA glycosylation pattern

The increased interest in predatory bacteria due to their ability to kill antibiotic resistant bacteria has also highlighted their inherent plethora of hydrolytic enzymes, and their potential as natural sources of novel therapeutic agents and biotechnological tools. Here, we have identified and characterized a novel protease from the predatory bacterium Bdellovibrio bacteriovorus: BspE (Bdellovibr

Dynamic site characterization for brownfield risk management

Site characterization for the design of thermoactive geostructures

Antibiotic Prophylaxis With Trimethoprim/Sulfamethoxazole Instead of Cloxacillin/Cefotaxime Increases Inguinal Surgical Site Infection Rate After Lower Extremity Revascularization

A Multi-Objective Optimization Approach for Solar Farm Site Selection: Case Study in Maputo, Mozambique

ITIS-PseKNC : Identification of Translation Initiation Site in human genes using pseudo k-tuple nucleotides composition

Impact of site-specific conjugation strategies on the pharmacokinetics of antibody conjugated radiotherapeutics

Studies on the interaction between vitamin K-dependent protein S and complement regulator C4b-binding protein: localization of binding sites and identification of a possible function of the complex.

Complement is a cascade-like system that is part of the innate immune defence. It is an explosive system, potentially harmful also for the host cells, and needs to be strictly regulated. An important down-regulator of complement is C4b-binding protein (C4BP). C4BP contains two different types of subunits, seven identical a-chains and one unique P-chain. The alpha-chains bind to C4b, C4BP's target

Site occupancy wave and charge density wave in the modulated structure of Nd_0.6Gd_0.4Se_1.85

Cultural conformity and persistence in Dickcissel song are higher in locations in which males show high site fidelity

Transradial versus trans-femoral access site in high-speed rotational atherectomy in Sweden

Recurrence, fidelity and proximity to previously visited sites throughout the annual cycle in a trans-Saharan migrant, the common cuckoo

Cultural responses to the 8.2 ka climatic event in North China : insights from the Jiahu archaeological site

Antigen-binding sites dominate the surface properties of IgG antibodies

Surgical Site Infections in Dermatologic Surgery- Clinical, diagnostic, and pathogenic aspects