Search results

Streptococcus pyogenes can cause invasive disease with high mortality despite adequate antibiotic treatments. To address this unmet need, we have previously generated an opsonic IgG1 monoclonal antibody, Ab25, targeting the bacterial M protein. Here, we engineer the IgG2-4 subclasses of Ab25. Despite having reduced binding, the IgG3 version promotes stronger phagocytosis of bacteria. Using atomic

Background: 4-1BB (CD137) is a co-stimulatory receptor highly expressed on tumor reactive effector T cells and NK cells, which upon stimulation prolongs persistence of tumor reactive effector T and NK cells within the tumor and induces long-lived memory T cells. 4-1BB agonistic antibodies have been shown to induce strong anti-tumor effects that synergize with immune checkpoint inhibitors. The firs

Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E

Popular science The carbon balance of the forest ecosystems is determined by the uptake and release of carbon. Forests take up carbon dioxide (CO2) by photosynthesis and release by respiration. One part of the assimilated carbon is respired back to the atmosphere by vegetation. The other part is respired by soil microbes which decompose organic material in soil. The microbial respiration is contro

Introduction The aim of this study is to determine the locations for school construction in two isolated mountainous communities in Gorno-Badakhshan Autonomous Oblast (GBAO) – Khorog and Porshnev towns. In recent decades, this region has become increasingly vulnerable to natural disasters. A major contributing factor to this vulnerability is the fact that very little land is available for human se

The interest for renewable energy within Australia is growing and the New South Wales (NSW) Government has committed to a Renewable Energy Target scheme of 20 percent renewable energy by 2020. Wind energy is a mature renewable energy resource, which has been successfully deployed for electricity generation around the world. It is further believed to be a viable option to help expand the renewable

Wind power development in Iceland is still on early stages where there are no wind farms and only a few wind turbines up and running in the whole country. However, the fast growing development of wind power that has been taking place in Europe and around the world has not gone unseen in Iceland. The interest in wind power is growing rapidly and the preparation of the development of the first wind

Kan en intelligent datormodell hjälp oss att skydda tjäderspelplatserna i de svenska skogslandskapen? Tjäderns mytomspunna spelplatser ligger dolda djupt inne i de vidsträckta svenska skogarna, och det är få som har förunnats att uppleva den fascinerande ritual som utspelar sig där varje vår. För att skydda dessa unika platser från mänsklig påverkan så finns det ett växande behov av att kunna loka