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Lymph node metastases as only qualifier for stage IV serous ovarian cancer confers longer survival than other sites of distant disease – a Swedish Gynecologic Cancer Group (SweGCG) study

Background: The International Federation of Gynecology and Obstetrics (FIGO) ovarian cancer staging system includes no sub-stage for lymph nodes (LN) as only distant disease manifestation. We explore the prognostic implication of LN as only stage IV classifier in serous ovarian cancer. Method: This is a nation-wide, population-based study on 551 women with serous stage IV cancers diagnosed between

Comparison of soldier fly (Diptera: Stratiomyidae) and thick-headed fly (Diptera: Conopidae) diversity at two trapping sites

Jämförelse av två flugfamiljers mångfald i två olika naturtyper Djurs mångfald är inte bara intressant utan även viktigt för att vår värld ska fungera i harmoni och kretsloppen ska slutas och gå runt. Vissa djur behövs för att bryta ned vissna växter och andra för att hålla insekters antal i schack. Några djur kan även vara tecken på om naturen mår bra eller dåligt. Olika naturtyper är hem för olBiodiversity is a big part of the understanding of our life and its surroundings. Only a fraction of the earth’s species are known and many are yet to be found. When describing new species often both molecular and morphological data is needed to fully resolve cryptic taxa. In this study, the diversity of two Diptera families, soldier flies (Stratiomyidae) and thick-headed flies (Conopidae), have b

Structure and dynamics of the active site of hen egg-white lysozyme from atomic resolution neutron crystallography

Hen egg-white lysozyme (HEWL) is a widely used model protein in crystallographic studies and its enzymatic mechanism has been extensively investigated for decades. Despite this, the interaction between the reaction intermediate and the catalytic Asp52, as well as the orientation of Asn44 and Asn46 side chains, remain ambiguous. Here, we report the crystal structures of perdeuterated HEWL and D2O b