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*Summary: The bacterium Escherichia coli is a common host organism for recombinant protein production. A problem encountered is the accumulation of the by-product acetate, which tends to reduce growth and protein production (1). Formation of acetate can be avoided by a proper substrate feeding strategy, but most strategies require considerable process knowledge to work well. The main problem is th
Popular Abstract in Swedish Medfödda hjärtfel hos barn är förenade med en varierande kombination av förtjockning av hjärtmuskeln, volym- och tryckbelastning av hjärtat, samt nedsatt syremättnad i blodet. Hos barn med medfödda hjärtfel, och förvärvade hjärtsjukdomar ändringar i kranskärlsblodflödet uppstå och påverka hjärtfunktionen eller leda till hjärtinfarkt. En tillförlitlig non-invasiv metod bHeart diseases in children cause different combinations of myocardial hypertrophy, increased intra-ventricular pressures, volume overload and decreased oxygen saturation. This may affect basal coronary flow and the ability of the heart to maximally increase coronary flow. Transthoracic and intracoronary Doppler techniques were used to register coronary flow and coronary flow reserve (CFR) in norma
Popular Abstract in Swedish I denna avhandling presenteras fyra nya metoder för att automatiskt mäta hjärtats förmåga att pumpa ut blod i kroppen, mäta storleken på en hjärtinfarkt samt mäta hur stor del av hjärtmuskeln som riskerade att dö vid hjärtinfarkten. Dessa nya metoder kan användas för att minska skillnader mellan mätningar gjorda av olika läkare, på olika sjukhus och i olika forskargruppIn this thesis four new algorithms are presented for automatic segmentation in cardiovascular magnetic resonance (CMR); automatic segmentation of the left ventricle, myocardial infarction, and myocardium at risk in two different image types. All four algorithms were implemented in freely available software for image analysis and were validated against reference delineations with a low bias and hig
A Single-Ion Hit Facility (SIHF) consists of a custom-build facility based in particle accelerators which offers irradiation controlling the number of delivered particles with a precise targeting localization. The irradiation spot can be confined down to the nanometre scale allowing the irradiation of subcellular compartments with a single particle. Therefore, these facilities have become a very p
Background Carrying the cyclin-dependent kinase inhibitor 2A (CDKN2A) germline mutations is associated with a high risk for melanoma. Penetrance of CDKN2A mutations is modified by pigmentation characteristics, nevus phenotypes, and some variants of the melanocortin-1 receptor gene (MC1R), which is known to have a role in the pigmentation process. However, investigation of the associations of both
Carbohydrates play a major role in many cell recognition events and metabolic pathways of living organisms. Synthetic carbohydrate receptors are of great interest for the chemical design of sugar sensors, materials for cell separation, cell immobilization, drug delivery and other biomedical/biotechnological applications. These receptors are more stable under harsh conditions and have lower cost as
The aggregating proteoglycans of the lectican family are important components of extracellular matrices. Aggrecan is the most well studied of these and is central to cartilage biomechanical properties and skeletal development. Key to its biological function is the fixed charge of the many glycosaminoglycan chains, that provide the basis for the viscoelastic properties necessary for load distributi
Expressions are derived for photoemission, which allow experimental electron energy loss data to be used for estimating losses in photoemission. The derivation builds on new results for dielectric response and mean free paths of strongly correlated systems of two-dimensional layers. Numerical evaluations are made for Bi2Sr2CaCu2O8 (Bi2212) by using a parametrized loss function. The mean free path
Introduction This study aims to clarify the role(s) of endogenous sex hormones to influence health outcomes in men, specifically to define the associations of plasma testosterone with incidence of cardiovascular events, cancer, dementia and mortality risk, and to identify factors predicting testosterone concentrations. Data will be accrued from at least three Australian, two European and four Nort
Tjänstearbetare, bland annat kvinnodominerade yrkesgrupper i offentlig välfärdssektor, står för en ökande andel av arbetskonflikter i världen. Därmed blir studier av strejker i offentlig sektor allt mer relevanta för att vidareutveckla förståelser av strejk som maktmedel. En forskningslucka finns särskilt avseende kommunalarbetares arbetsinställelser. Med målsättningen att utforska villkoren för oThe tertiary sector accounts for a rising share of labour disputes, making studies of public sector strikes increasingly relevant to the understanding of labour market power relations. With the intention of exploring conditions for public sector labour struggles, this study aims to empirically examine the extensive 2003 wage strike carried out by the Swedish Municipal Workers’ Union [Kommunal]. It
Monitoring soil moisture at the Earth'surface is of great importance for drought early warnings. Spaceborne remote sensing is a keystone in monitoring at continental scale, as satellites can make observations of locations which are scarcely monitored by ground-based techniques. In recent years, several soil moisture products for continental scale monitoring became available from the main space age
