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The Mini-Organo : A rapid high-throughput 3D coculture organotypic assay for oncology screening and drug development

Background: The use of in vitro cell cultures is a powerful tool for obtaining key insights into the behaviour and response of cells to interventions in normal and disease situations. Unlike in vivo settings, in vitro experiments allow a fine-tuned control of a range of microenvironmental elements independently within an isolated setting. The recent expansion in the use of three-dimensional (3D) i

Distress and profile data analysis for condition assessment in pavement management systems

Pavement data collection is the most expensive and time consuming component of Pavement Management System (PMS). Thus, possible methods of minimizing the need of such data might be critical in reducing pavement condition monitoring costs. Also the ability to relate pavement performance prediction models (frequently roughness based) to hot mix asphalt field performance models (distress based) provi

An exploration of competitiveness and caring in relation to psychopathology

Objectives. Social mentality theory outlines how specialist systems have evolved to facilitate different types of social behaviour such as caring for offspring, forming alliances, and competing for resources. This research explored how different types of self-experience are linked to the different social mentalities of competitive social ranking (focusing on gaining and defending one's social posi

New contact allergens are formed during vulcanization of rubber

In rubber materials, both natural rubber and synthetic rubber, several different contact allergenic chemicals are added to the batch before vulcanization. These compounds are relevant for investigation of rubber allergy of workers in rubber factories. The number of workers in the rubber industry has declined, owing to increased automation of the process; however, the number of users of rubber prod

Design and validation of Segment - freely available software for cardiovascular image analysis

Background: Commercially available software for cardiovascular image analysis often has limited functionality and frequently lacks the careful validation that is required for clinical studies. We have already implemented a cardiovascular image analysis software package and released it as freeware for the research community. However, it was distributed as a stand-alone application and other researc

Performance improvement of automated melanoma diagnosis system by data augmentation

Color information is an important tool for diagnosing melanoma. In this study, we used a hyper-spectral imager (HSI), which can measure color information in detail, to develop an automated melanoma diagnosis system. In recent years, the effectiveness of deep learning has become more widely accepted in the field of image recognition. We therefore integrated the deep convolutional neural network wit

Implementation of knowledge-based palliative care in nursing homes and pre-post post evaluation by cross-over design: a study protocol

BackgroundThe demography of the world is changing as the population is ageing. Because of this change to a higher proportion of older people, the WHO has called for improved palliative care for older persons. A large number of all deaths in the industrialised world occur while older people are living in nursing homes and therefore a key question becomes how the principles of palliative care can be

OS089. Elevated levels of the heme scavenger alpha-1-microglobulin in maternal plasma at the end of first trimester in patients who subsequently develop preeclampsia

INTRODUCTION: Resent research has revealed an increased concentration of free fetal hemoglobin (HbF) in maternal serum from patients who subsequently develops preeclampsia (PE). In a previous study of 96 patients we have shown that HbF in combination with the heme-scavenger alpha-1-microglobulin (A1M) are potential predictive biomarkers of PE.OBJECTIVES: In this validating case-control study we ai

Precision mapping of gene expression and proteins in the brain using gene editing and barcoded viral vectors

The human brain is a masterpiece of intricate design and impeccable functionality. It serves as the ultimate command center for our thoughts, sensations, and actions, which define our very existence. This organ operates flawlessly, with billions of neurons working in perfect harmony to process information, create memories, and regulate our emotions. The brain's neural network is composed of trilli

A Swedish Dilemma : Culture and Rule of Law in Swedish Sickness Insurance

Sverige har både beskrivits som modernt, liberaldemoratiskt och djupt humanitärt; och som mer eller mindre förmodernt, halvauktoritärt och benäget att kränka svaga gruppers rättigheter. I den här avhandlingen undersöks detta svenska dilemma i en rättsantropologisk tradition, med studier av konfliktlösningspraktiker som ett sätt att förstå förhållandet mellan lag och kultur.Detaljerade data från tj

Rose hip supplementation increases energy expenditure and induces browning of white adipose tissue

Background: Overweight and obesity are widespread chronic disorders defined as excessive fat accumulation, and are major risk factors for several chronic diseases including type 2 diabetes, coronary heart disease, high blood pressure and fatty liver. Changes in lifestyle such as increased physical activity and a healthy diet can be crucial tools for treating obesity. Intake of rose hip, the fruit