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Association of int2/hst1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis
HER-2/neu and INT2 proto-oncogene amplification in malignant breast tumors in relation to reproductive factors and exposure to exogenous hormones
Design Beyond Zoning : Negotiating Architectural Form and Bulk Restrictions at HL23
This article uses Neil M. Denari’s HL23 condominium tower in West Chelsea, New York City, as the lens through which to focus on the architectural design pathway in discretionary reviews to negotiate architectural form and bulk restrictions. The argument states that creative architectural forms can appropriate an unorthodox site configuration in accord with planning objectives and that review proce
Increased vimentin in human α- and β-cells in type 2 diabetes
Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease
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Since the mid 1970's, when Adey discovered that extremely-low-frequency electromagnetic field (ELF EMF) may affect the calcium ions efflux from various cells, bioeffects of non-ionizing radiation (NIR) have become the subject of growing interest and numerous research projects. At present, the fact that NIR exerts both stimulatory and inhibitory effects on different physiological cellular parameter
Elucidating recent history by tracing genetic affinity of three 16th century miners from Sweden
Objectives: Sala Silver Mine in central Sweden was an important manufacturer of silver from at least the 16th till the early 20th century, with production peaking in the 16th, mid 17th and 19th centuries. The job opportunities offered by the mine attracted people to the area resulting in the development of a small township with an associated cemetery in the vicinity of the mining center. People af
Self-sampling with HPV mRNA analyses from vagina and urine compared with cervical samples
Prevalence of osteoporosis and incidence of hip fracture in women--secular trends over 30 years.
Truncation of SNAP-25 reduces the stimulatory action of cAMP on rapid exocytosis in insulin-secreting cells.
SNAP-25 is important for Ca(2+)-dependent fusion of Large Dense Core Vesicles (LDCVs) in insulin-secreting cells. Exocytosis is further enhanced by cAMP-increasing agents such as GLP-1 and this augmentation includes interaction with both PKA and cAMP-GEFII. To investigate the coupling between SNAP-25 and cAMP-dependent stimulation of insulin exocytosis we have used capacitance measurements, protei
Secretory Leukocyte Protease Inhibitor inhibits neutrophil apoptosis.
SUMMARY AT A GLANCE: Secretory leukocyte proteinase inhibitor (SLPI) is a major anti-elastase barrier at the epithelial surfaces of upper respiratory tract. Our findings indicate clear up-regulation of SLPI in response to endotoxin in nasal secretions. In addition, SLPI shows dose-dependent anti-apoptotic and chemotactic effects on primary human neutrophils. ABSTRACT: Background and objective: The
Dopamine release from serotonergic nerve fibers is reduced in L-DOPA-induced dyskinesia.
Exercise and asthma: an overview.
The terms 'exercise-induced asthma' (EIA) and 'exercise-induced bronchoconstriction' (EIB) are often used interchangeably to describe symptoms of asthma such as cough, wheeze, or dyspnoea provoked by vigorous physical activity. In this review, we refer to EIB as the bronchoconstrictive response and to EIA when bronchoconstriction is associated with asthma symptoms. EIB is a common occurrence for m