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Truncation of SNAP-25 reduces the stimulatory action of cAMP on rapid exocytosis in insulin-secreting cells.
SNAP-25 is important for Ca(2+)-dependent fusion of Large Dense Core Vesicles (LDCVs) in insulin-secreting cells. Exocytosis is further enhanced by cAMP-increasing agents such as GLP-1 and this augmentation includes interaction with both PKA and cAMP-GEFII. To investigate the coupling between SNAP-25 and cAMP-dependent stimulation of insulin exocytosis we have used capacitance measurements, protei
Secretory Leukocyte Protease Inhibitor inhibits neutrophil apoptosis.
SUMMARY AT A GLANCE: Secretory leukocyte proteinase inhibitor (SLPI) is a major anti-elastase barrier at the epithelial surfaces of upper respiratory tract. Our findings indicate clear up-regulation of SLPI in response to endotoxin in nasal secretions. In addition, SLPI shows dose-dependent anti-apoptotic and chemotactic effects on primary human neutrophils. ABSTRACT: Background and objective: The
Dopamine release from serotonergic nerve fibers is reduced in L-DOPA-induced dyskinesia.
Exercise and asthma: an overview.
The terms 'exercise-induced asthma' (EIA) and 'exercise-induced bronchoconstriction' (EIB) are often used interchangeably to describe symptoms of asthma such as cough, wheeze, or dyspnoea provoked by vigorous physical activity. In this review, we refer to EIB as the bronchoconstrictive response and to EIA when bronchoconstriction is associated with asthma symptoms. EIB is a common occurrence for m
Effect of charge on microvascular permeability in early experimental sepsis in the rat.
Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis.
Evolution of P-wave morphology in healthy individuals: a 3-year follow-up study.
Randomized healthservices study of human papillomavirus-based management of low-grade cytological abnormalities.
Long-term prophylaxis in severe haemophilia seems to preserve bone mineral density.
Risk of malignant melanoma in men with prostate cancer: Nationwide, population-based cohort study.
Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family.
Angptl4 maintains in vivo repopulation capacity of CD34(+) human cord blood cells.
Family history and risk of hospital treatment for varicose veins in Sweden.
Ranking of genome-wide association scan signals by different measures.
Phosphorylation and activation of phosphodiesterase type 3B (PDE3B) in adipocytes in response to serine/threonine phosphatase inhibitors: deactivation of PDE3B in vitro by protein phosphatase type 2A
Using a generalized vegetation model to simulate vegetation dynamics in northeastern USA
Models based on generalized plant physiological theory represent a promising approach for describing vegetation responses to environmental drivers on large scales but must be tested for their ability to reproduce features of real vegetation. We tested the capability of a generalized vegetation model (LPJ-GUESS) to simulate vegetation structural and compositional dynamics under various disturbance
Experimental excursions on adaptive landscapes: Density-dependent selection on egg size
Total chemical synthesis and NMR characterization of the glycopeptide tx5a, a heavily post-translationally modified conotoxin, reveals that the glycan structure is alpha-D-Gal-(1 -> 3)-alpha-D-GalNAc
The 13-amino acid glycopeptide tx5a (Gla-Cys-Cys-Gla-Asp-Gly-Trp*-Cys-Cys-Thr*-Ala-Ala-Hyp-OH, where Trp* = 6-bromotryptophan and Thr* = Gal-GalNAc-threonine), isolated from Conus textile, causes hyperactivity and spasticity when injected intracerebral ventricularly into mice. It contains nine post-translationally modified residues: four cysteine residues, two gamma-carboxyglutamic acid residues,
