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The Wnt signaling pathway is highly conserved and crucial during embryonic development. Aberrant Wnt signaling is important in several different disease processes. One such disease process is the development and progression of cancer. Malignant melanoma is a highly aggressive tumor type, in which Wnt signaling is essential. Once a melanoma tumor has spread and formed metastasis, there are few trea
Popular Abstract in Swedish Avhandlingen undersöker teologen Gustaf Wingrens (1910-2000) kyrkosyn och relaterar den till den nutida diskussionen om Svenska kyrkan som folkkyrka. Tre viktiga frågor ställs till Wingren och andra teologer och debattörer, som ingår i undersökningen, nämligen: Vad är kyrkan? (om kyrkans väsen). Vem är kyrka? (om gränser, medlemskap och auktoritet). Var är kyrkan? (om kThis thesis explores the ecclesiology of the Swedish theologian Gustaf Wingren and discusses the future of the "folk church". Three questions What, Who and Where is the Church? sustain the structure of this investigation. Wingren reflected on issues related to the openness and the identity of the church. His main concern was the interpretation the gospel as the liberating message to the guilt-ridd
The time that it takes an occupant population to reach safety when descending a stair during building evacuations is typically estimated by measureable engineering variables such as stair geometry, speed, stair density, and pre-observation delay. In turn, engineering models of building evacuation use these variables to predict the performance of egress systems for building design, emergency planni
The soon-to-be completed Grand Ethiopian Renaissance Dam (GERD), which will be the largest hydroelectric power plant and among the largest reservoirs in Africa, has highlighted the need for expanding traditional integrated water resources management to better include the cultural, social, and political complexities of large water infrastructure in development projects. The GERD will store a maximu
Popular Abstract in Swedish Trumljud är det ljud som hörs i ett rum då ett objekt, till exempel en fot, träffar golvytan i samma rum. Ökande användning av tunna och hårda golvbeläggningar, såsom parkett och laminatgolv, kan leda till ljudstarka och skarpa ljud, vilket har ökat intresset av trumljud. En prediktionsmodell för den subjektiva responsen av trumljud vid en parvis jämförelse har tagits fDrum sound is the sound produced when an object, such as a foot, hits the flooring in the room in which the receiving ear is located. Drum sound has attracted interest in recent years, particularly due to an increased use of thin floating floor constructions, such as veneer or laminate flooring, which can produce loud and sharp walking sound. A prediction model of the subjective response, in a pai
This thesis delves into two ‘edge areas’ located in and around East Jerusalem. It attempts to unfold and analyze the dynamics in these edge areas, while investigating the agency of the people present there through their own perceptions and practices towards the land, the urbanization processes, the power circulation and the structural impositions. Squeezed by a settler-colonial domination that con
During recent years, numerous studies have shown the ability of dietary fiber toprotect the colon from disease and to improve intestinal health. Beneficial healtheffects, such as the lowering of blood cholesterol levels and a reduction in the risk of coronary heart disease, are often directly related to cereal β-glucan, one of the major components of dietary fiber found in oat and barley. No defin
In England saltmarshes account for less than 0.5% of the land area; however they have a very high biodiversity value and provide significant economic and social services. Climate change, continuous coastal urbanisation and port development are serious concerns for coastal protection planners, city councils and state government agencies interested in balancing the social, economic and environmental
Background: Models describing nuclear fragmentation and fragmentation fission deliver important input for planning nuclear physics experiments and future radioactive ion beam facilities. These models are usually benchmarked against data from stable beam experiments. In the future, two-step fragmentation reactions with exotic nuclei as stepping stones are a promising tool for reaching the most neut
