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Neuromuscular disorders are often caused by heterogeneous mutations in large, structurally complex genes. Targeting compensatory modifier genes could be beneficial to improve disease phenotypes. Here we report a mutation-independent strategy to upregulate the expression of a disease-modifying gene associated with congenital muscular dystrophy type 1A (MDC1A) using the CRISPR activation system in m
This thesis delves into two ‘edge areas’ located in and around East Jerusalem. It attempts to unfold and analyze the dynamics in these edge areas, while investigating the agency of the people present there through their own perceptions and practices towards the land, the urbanization processes, the power circulation and the structural impositions. Squeezed by a settler-colonial domination that con
Denna avhandling har tre utgångspunkter. Den första är den europeiska sociala dialogen (ESD), vilken har kritiserats för att sakna kapacitet för att förbättra arbetsvillkor i EU. Den andra är det globala systemet för kollektivavtal och förhandlingar som har utvecklats genom ITFs kampanj mot bekvämlighetsflagg (ITF FOC), vilket anses ha kapacitet att förbättra villkor för sjömän på global nivå. DenThere are three starting points for this thesis. First, there is the system of ESD, which is criticised for lacking capacity to improve the working conditions within the EU. Secondly, there is the system developed through the global ITF FOC campaign, which is considered to have capacity to improve working conditions for seafarers at a global level. Thirdly, there is the theory on self-referential
Contemporary debates on sustainability usually relies on standardised and normative categories, such as ‘social’ and ‘nature’, and on linear notions of time. This study explores a more complex perspective on the delicate borderlands between the ‘un-sustainable’ and the ‘sustainable’. A particular material and a particular place stand at the centre of attention: woollen Merino fibre on the South Am
The most severe urban flooding in cold maritime climates is due to the co-action of long-duration rainfall, snowmelt, and soil frost. Increasing winter air temperature due to climate change is projected to change the magnitude and frequency of rain-on-snow (RoS) events and increase the number of freeze–thaw cycles and midwinter snowmelt. While daily rainfall records are readily available, less is
Individual monitoring of radiation workers is essential to ensure compliance with legal dose limits and to ensure that doses are As Low As Reasonably Achievable. However, large uncertainties still exist in personal dosimetry and there are issues with compliance and incorrect wearing of dosimeters. The objective of the PODIUM (Personal Online Dosimetry Using Computational Methods) project was to im
