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WUSCHEL (WUS) is a homeodomain transcription factor produced in cells of the niche/organizing center (OC) of shoot apical meristems. WUS specifies stem cell fate and also restricts its own levels by activating a negative regulator, CLAVATA3 (CLV3), in adjacent cells of the central zone (CZ). Here we show that the WUS protein, after being synthesized in cells of the OC, migrates into the CZ, where
Syftet med detta examensarbete har varit att undersöka täckningsprincipen i svensk rätt, med ett särskilt fokus på dess tillämpning när ansvar för medhjälp aktualiseras. Målet har varit att försöka utreda dels vilka krav gällande rätt uppställer vid uppsåtstäckningen vid medhjälp och dels bidra med ett normativt perspektiv genom att granska gällande rätt ur ett konformitets- och skuldperspektiv. D
Using all-atom Monte Carlo simulations with implicit water, combined with a cluster size analysis, we study the aggregation of A16-22, a peptide capable of forming amyloid fibrils. We consider a system of six initially randomly oriented A16-22 peptides, and investigate the thermodynamics and structural properties of aggregates formed by this system. The system is unaggregated without ordered secon
Ankylosing spondylitis (AS) is a chronic inflammatory disease in which genetic factors play a central role. The efficacy of TNF blockers has reoriented research in this field in order to explain the influence of TNF in AS pathogenesis. The objective of this study was to access the influence of single nucleotide polymorphisms (SNPs) at positions -308 and -238 of the promoter region of TNF gene on A
Abstract in UndeterminedBackground: For 2-dye microarray platforms, some missing values may arise from an un-measurably low RNA expression in one channel only. Information of such "one-channel depletion" is so far not included in algorithms for imputation of missing values.Results: Calculating the mean deviation between imputed values and duplicate controls in five datasets, we show that KNN-based
A reduced protein model with five to six atoms per amino acid and five amino acid types is developed and tested on a three-helix-bundle protein, a 46-amino acid fragment from staphylococcal protein A. The model does not rely on the widely used Go approximation, which ignores non-native interactions. We find that the collapse transition is considerably more abrupt for the protein A sequence than fo
The plant shoot apical meristem holds a stem cell niche from which all aerial organs originate. Using a computational approach we show that a mixture of monomers and heterodimers of the transcription factors WUSCHEL and HAIRY MERISTEM is sufficient to pattern the stem cell niche, and predict that immobile heterodimers form a regulatory ‘pocket’ surrounding the stem cells. The model achieves to rep
Lifetimes have been measured in a superdeformed rotational band recently identified in the N = Z nucleus 36Ar. A large low-spin quadrupole deformation (β2=0.46±0.03) is confirmed and a decrease in the collectivity is observed as the high-spin band termination at Iπ=16+ is approached. Detailed comparisons of the experimental B(E2) values with the results of cranked Nilsson-Strutinsky and large-scal
I det internationella samarbetet som rör utlämning på grund av brott finns den folkrättsliga principen aut dedere aut judicare. Den innebär att om en stat vägrar att utlämna en person, ofta mot bakgrund av att personen är medborgare i den staten, kan staten åta sig att lagföra personen för den brottslighet hen är misstänkt för. Uppsatsens fokus har varit att utreda ifall en sådan lagföring regelmä
In spite of our current knowledge regarding the biology underlying cancer genesis, reliable methods for the discovery of cancer driver (CD) genes are still in great need. The rather recent incorporation of epigenetic markers to the cancer paradigm has nevertheless opened the door for the development of new computational approaches to the problem. This work is aimed to study the enrichment of cer
The purpose with this paper is to put forward the complexity with employees’ identification with an organizations brand and the organization overall. We wish to examine the effects of internal employer branding, both through mainstream perspectives as well as through normative control. We hope to contribute with empirical support and deepen the knowledge for the impact that the brand has for the e
Backgrund: Nederman har ett långsiktigt mål att förbättra enheten i Helsingborg. Ett steg i detta är att se om det finns några förbättringar att genomföra i lagerstyrningen i form av lager- och servicenivåer. Detta då de anställda upplever dagens verktyg som ganska trubbiga för det nuvarande produktsortimenetet och att detta kanske kan förbättras genom ytterliggare en dimension på det befintliga sBackground: Nederman has a long term goal of improving their supply unit in Helsingborg. One step of this is to investigate if there are any improvements to be made in the inventory control in terms of stock levels and service level. This since the employees at Nederman believes that the existing methods are too blunt as a tool for the product range and that their methods can be improved by adding
only using electric-dipole forbidden emission lines, in what we label forbidden-line spectroscopy, we identified several energy levels in cadmium-like tungsten, W26+. The spectrum was recorded at the Shanghai permanentmagnet electron beam ion trap in the visible region. The identifications were supported by large-scale multiconfiguration Dirac-Hartree-Fock calculations which involved careful inves
Convolutional neural networks (CNNs) are used to classify directly on bone scan images in two medical tasks: classifying anterior / posterior pose, and classifying bone scan hotspots as metastatic / non-metastatic in patients with prostate cancer and suspected metastatic disease. The networks trained produce highly accurate results in both tasks and current methods are outperformed for all tested
Popular Abstract in Swedish Kontroll av fororeningar i dagens fusionsmaskiner aer ett inte alltfor stort problem. De kan dock anvandas for diagnostiskt syfte eftersom deras linjeemission avslojar ett flertal intressanta plasmaparametrar. For att kunna maeta egenskaper som jontemperatur, jondensitet och plasmarotation i ett fusionsplasma, aer det av yttersta vikt att den spektroskopiska tolkningen
We properly define off-shell K → π transition amplitudes and use them to extract information for on-shell K → ππ amplitudes within Chiral Perturbation Theory. At order p2 in the chiral expansion all three parameters of weak interaction can be determined. At order p4 we are able to fix eleven additional constants out of thirteen contributing to off-shell K → π transitions, which leaves four undeter
