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Infant and adult MLL1/KMT2A-rearranged (MLLr) leukemia represents a disease with a dismal prognosis. Here, we present a functional and proteomic characterization of in utero-initiated and adult-onset MLLr leukemia. We reveal that fetal MLL::ENL-expressing lymphomyeloid multipotent progenitors (LMPPs) are intrinsically programmed towards a lymphoid fate but give rise to myeloid leukemia in vivo, hi

Multi-junction photovoltaics approaches are being explored to mitigate thermalization losses that occur in the absorption of high-energy photons. However, the design of tandem cells faces challenges such as light reflection and parasitic absorption. Nanostructures have emerged as promising solutions due to their anti-reflection properties, which enhances light absorption. III-V nanowires (NWs) sol

The purpose of the thesis is to examine to what extent former high ranking state officials are immune for international crimes before foreign national courts. Historically national courts have recognized absolute immunity, but this approach has gradually to some extent changed after the establishment of international tribunals and the International Criminal Court in which official capacity is irre

The aim of this thesis is to gather an understanding of the creation of unlikely alliances within the environmental movement as a social movement. This is done in turn done by looking at the resistance among the environmental movement as well as grassroots organizations that arose around the proposal to build a pipeline called Keystone XL made by the Canadian oil company TransCanada in 2008. The f

Diploid potato cultivars that are propagated by True Potato Seeds (TPS) are a new potentially revolutionary way of potato breeding. Conventional breeding is based on highly heterozygous tetraploid potato varieties. Diploid potato breeding by TPS is useful to create inbred lines and from there hybrid offspring. TPS is cheaper, has almost no diseases and is easy to distribute. Diploid potatoes have Are potatoes, grown from seeds, the future? Did you know that you can grow potato plants from seeds? A potato plant has two ways to propagate itself; by the all known potato that we love to eat and by seeds that are grown in tomato-like berries above the ground. These seed producing potato plants that are as well diploid (two copies of every chromosome) instead of conventional tetraploid (4 copie

The aim of this study was to investigate the motivational work in needle exchanges. The analysis was based on two theories; a theory of Per Revstedt and the pygmalioneffect. The study is based on qualitative interviews with seven person (six women and one man) who work in needle exchanges. The interviews is later analysed. The results show that the respondents express that the goal with the motiva

The nomadic pastoralists of the Sahel are often identified as a group at the frontline of global climate change. Their existence in arid and semi-arid regions and their reliance on seasonal rainfall are among the factors that contribute to their vulnerability to drought and climate shocks. This study focuses on risks to pastoralists in Sudan, asking whether index-based livestock insurance, an innoPastoralism is a nomadic lifestyle and a livelihood system that revolves around raising livestock. By migrating seasonally in search of water and pasture for their animals, pastoralists are able to inhabit and make productive use some of the world’s harshest environments. In Sudan, where over 90% of the vast land area is covered by desert and drylands, pastoralism remains a vital feature of the co

The focus of my thesis has been the Swedish lay judges. My purpose has been to examine the Swedish system of lay judges and furthermore study it in relation to legal certainty. My major problem statement has been: In accordance with legal certainty, what advantages and disadvantages can be seen with the system of lay judges? The Swedish lay judges participate primarily in district and appellate c

My thesis ’’Responsibility to create sustainability – a concept analysis of responsibility in the sustainability reports of the Swedish fashion industry’’, investigates Hennes & Mauritz and Filippa Ks view of the concept responsibility in sustainability reports, be- fore and after the adoption of The Sustainable development goals. The purpose of this study is to uncover if the enterprises view

Syfte: Huvudsyftet med studien var att undersöka den phonicsbaserade lärappen GraphoLearns effekter på avkodningsförmågan hos svensktalande barn i tidig läsutveckling. Sekundärt var syftet att undersöka huruvida träning med GraphoLearn kan påverka hjärnstruktur. Studien kan betraktas som en pilotstudie för ett större pågående projekt. Metod: Fjorton deltagare i åldrarna 6 till 7 år inkluderades. S

I denna uppsats står rädsla för att tala i fokus. Talrädsla belyses med retorikämnet som grund, och studien tar avstamp i den svenska gymnasieskolan. Syftet med studien är att ta fram ett handfast material för hur svensklärare på gymnasieskolan kan arbeta med talrädda elever. För att uppnå syftet genomförs en litteraturstudie, där handböcker som behandlar området talrädsla studeras. I dessa handböIn this study, language anxiety is in focus. Language anxiety is studied with the subject of rhetoric as a basis, and the study is based on the Swedish upper secondary school. The aim of the study is to produce a solid material for how Swedish teachers at upper secondary school can work with students with language anxiety. In order to achieve this purpose, a literature study is carried out, in whi

An urban nature experience – an urban park where people can experience and improve the relationship between human and nature. This is an exhibition of nature in an urban environment. Here you can experience the nature with all of your senses; sight, smell, touch, sound and taste. Research has shown that the more people are exposed to nature, the more they appreciate it, and the more environmental

Våld i nära relationer och särskilt mäns våld mot kvinnor, anses idag utgöra ett allvarligt samhällsproblem. Det finns studier som visar att ungefär vart tionde barn i Sverige någon gång har upplevt våld mellan närstående vuxna. Detta kan få förödande konsekvenser för barnet i form av både fysiska och psykiska skador. Att låta barn bevittna våld eller andra brottsliga gärningar mellan närstående äViolence in close relationships and especially men’s violence against women, is today considered a social problem. There are studies showing that approximately every tenth child in Sweden has ever experienced violence between related adults. This can cause devastating consequences for a child, such as both physical and mental injuries. Letting children witness violence or other criminal acts betwe

Denna uppsats handlar om den delen av kvinnorörelsens historia där kvinnors rätt till högre statstjänster berörs. I takt med industrialiseringen förändrades det svenska samhället och medförde att kvinnor tog plats på arbetsmarknaden på ett helt annat sätt än tidigare. Sedan mitten av 1800-talet var kvinnor aktiva på den statliga arbetsmarknaden och fick tillträde till universitetsstudier i början This essay is about the part of the history of the women's movement where women's right to higher civil service is affected. In time as the industrialization happened, Swedish society changed which resulted in that women took their place in the labor market in a completely different way than before. Since the middle of the 19th century, women were active in the state labor market and gaine

To assess presence of virus DNA in skin lesions, swab samples from 82 squamous cell carcinomas of the skin (SCCs), 60 actinic keratoses (AKs), paraffin-embedded biopsies from 28 SCCs and 72 kerathoacanthomas (KAs) and fresh-frozen biopsies from 92 KAs, 85 SCCs and 92 AKs were analyzed by high throughput sequencing (HTS) using 454 or Ion Torrent technology. We found total of 4,284 viral reads, out

Arterial stiffness reflects the ageing processes in the vascular system, and studies have shown an association between reduced cognitive function and cerebral small vessel disease. Small vessel disease can be visualized as white matter hyperintensities (WMH) and lacunar infarcts but also as cerebral microbleeds on brain magnetic resonance imaging (MRI). We aimed to investigate if arterial stiffnes

BACKGROUND: To explore the level of physical activity in a population based sample of older adults; to analyze the influence of pain characteristics and fear-avoidance beliefs as predictors of physical activity among older adults reporting chronic pain. METHODS: Demographics, pain characteristics (duration, intensity), physical activity, kinesiophobia (excessive fear of movement/(re) injury), se