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BackgroundSexual violence is widespread in the eastern parts of the Democratic Republic of the Congo, including in the North Kivu province. Moreover, in this region survivors of sexual violence often have limited access to care and encounter a variety of barriers when seeking care and support. The aim of this study was to explore community perceptions about access to care, barriers, enablers and pBackgroundSexual violence is widespread in the eastern parts of the Democratic Republic of the Congo, including in the North Kivu province. Moreover, in this region survivors of sexual violence often have limited access to care and encounter a variety of barriers when seeking care and support. The aim of this study was to explore community perceptions about access to care, barriers, enablers and p

We hypothesize that predictable variations in environmental conditions caused by night/day cycles created opportunities and hazards that initiated information dynamics central to life’s origin. Increased daytime temperatures accelerated key chemical reactions but also caused the separation of double-stranded polynucleotides, leading to hydrolysis, particularly of single-stranded RNA. Daytime solar

Disaster risk management has seen the importance of coordination at various levels of planning and implementation, ranging from preparedness to disaster response, and in planning for long term recovery and sustainable development. This thesis aims to develop a deeper and analytical understanding of stakeholder coordination for disaster recovery. The thesis is built on case studies from the mega –d

Research question: How are organizations integrating ethical and strategic considerations into their approaches to AI implementation? Purpose: The purpose of this research is to systematically map ethical and strategic themes relevant to Artificial Intelligence Systems within the business context from a practitioner standpoint. This study aims to contribute to the understanding of this research fi

In addition to the family context, persons in the neighborhood and community are important for individual life course, socioeconomic and demographic outcomes such as education, career and family transitions. This paper aims to study how neighborhood conditions in childhood influence fertility outcomes in adulthood. Theories focusing on motivation, aspirations and attitudes or peer influence genera

BACKGROUND: Obesity rates have nearly tripled in the past 50 years, and by 2030 more than 1 billion individuals worldwide are projected to be obese. This creates a significant economic strain due to the associated non-communicable diseases. The root cause is an energy expenditure imbalance, owing to an interplay of lifestyle, environmental, and genetic factors. Obesity has a polygenic genetic arch

Background: There are multiple known associations between the ABO and RhD blood groups and disease. No systematic population-based studies elucidating associations between a large number of disease categories and blood group have been conducted. Methods: Using SCANDAT3-S, a comprehensive nationwide blood donation-transfusion database, we modelled outcomes for 1,217 disease categories including 70

The loading of terrestrially derived macroelements, such as dissolved organic carbon (DOC), total nitrogen (N), and total phosphorus (P), to inland and estuarine waters is increasing in the northern hemisphere. Thesemacroelements often limit heterotrophic bacterioplankton metabolism (production and respiration), which in turn influence food web structures, exchange of greenhouse gases between the

Risk analysis is important for safety-critical IT systems and services, both in public and private organizations. However, the actual practices and the challenges of risk analysis in these contexts have not been fully explored. This paper investigates the current practices of risk analysis by an interview-based investigation. This study investigates several factors of the risk analysis process, e.

The aim of this study was to investigate the risk of developing preeclampsia (PE) associated with gestational exposure to ambient air pollutants in southern Sweden, a low-exposure area. We used a cohort of 43,688 singleton pregnancies and monthly mean exposure levels of black carbon (BC), local and total particulate matter (PM2.5 and PM10), and NOX at the maternal residential address estimated by

Aim and objectives: To explore newly employed nurses’ socialisation in the process of introduction into an oncological clinic from the perspectives of unit managers and newly employed nurses. Background: There are managerial challenges in retaining nurses at workplaces. The way in which nurses are socialised into their work is important for their job satisfaction and retainment. Method: Qualitativ

OBJECTIVES: Chronic lung allograft dysfunction including Bronchiolitis obliterans syndrome (BOS) is common after lung transplantation. Histologically, BOS is recognized as fibrotic lesions with accumulated extracellular matrix (ECM) in small airways. Lung fibroblasts are major producers of ECM and vascular endothelial growth factor (VEGF). In this study we hypothesize that VEGF is involved in BOS

The clinically important MAM blood group antigen is present on haematopoietic cells of all humans except rare MAM-negative individuals. Its molecular basis is unknown. By whole-exome sequencing we identify EMP3, encoding epithelial membrane protein 3 (EMP3), as a candidate gene, then demonstrate inactivating mutations in ten known MAM-negative individuals. We show that EMP3, a purported tumour sup

This work is primarily about the development, validation and application of computer simulation models for intrinsically disordered proteins, both in solution and in the presence of uniformly charged, ideal surfaces. The models in question are either coarse-grained or atomistic in nature, and their applications are dependent on the specific purpose of each study. Both, Metropolis Monte Carlo and m

Municipal wastewater treatment plants are constantly forced to make improvements. The main objectives are to reduce energy consumption, to increase the treatment capacity and to improve the effluent water quality. Microsieves in combination with chemical pretreatment can potentially fulfil these objectives. In this work, experiments were mainly conducted at the large pilot scale, and supplementaryMunicipal wastewater treatment plants are constantly forced to make improvements. The main objectives are to reduce energy consumption, to increase the treatment capacity and to improve the effluent water quality. Microsieves in combination with chemical pretreatment can potentially fulfil these objectives. In this work, experiments were mainly conducted at the large pilot scale, and supplementary

The kinetics and mechanism for the overall reaction (i) (X = Cl or Br) have been studied at 25.0 °C using stopped-flow spectrophotometry. 3[AuX4]–+ 7SCN–+ 4H2O → 3[Au(SCN)2]–+ HSO4–+ HCN + 12X–+ 6H+ (i) The reaction takes place in two kinetically well separated steps. The initial, rapid process can be identified as stepwise ligand substitutions (ii) (n= 0–3) which take place via direct ligand

PURPOSE: Welders are exposed to airborne particles from the welding environment and often develop symptoms work-related from the airways. A large fraction of the particles from welding are in the nano-size range. In this study we investigate if the welders' airways are affected by exposure to particles derived from gas metal arc welding in mild steel in levels corresponding to a normal welding day

At present, air conditioning (AC) is the most effective means for the cooling of indoor space. However, its increased global use is problematic for various reasons. This is a correspondence to the supplementary opinion provided by Dr. Bin Yang, Dr. Stefano Schiavon, and Dr. Faming Wang to our paper titled “Challenges of using air conditioning in an increasingly hot climate.” The paper explored the

Mutations in the glucocerebrosidase (GBA) gene have been associated with the development of Parkinson's disease (PD). An induced pluripotent stem cell (iPSC) line was generated from a 60-year old patient diagnosed with PD and carrying a new mutation variant p.R301C in GBA. Using non-integrating Sendai virus-based technology, we utilized OCT3/4, SOX2, c-MYC and KLF4 transcription factors to reprogr

The protein parkin, encoded by the PARK2 gene, is vital for mitochondrial homeostasis, and although it has been implicated in Parkinson’s disease (PD), the disease mechanisms remain unclear. We have applied mass spectrometry-based proteomics to investigate the effects of parkin dysfunction on the mitochondrial proteome in human isogenic induced pluripotent stem cell-derived neurons with and withou