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I min avhandling undersöker jag varierande placering av objekt till verb i svenskans historia. Primärt undersöks placering av nominala objekt visavi negerande adverbial, och sekundärt undersöks placering av nominala objekt visavi andra argument (subjekt och objekt) i huvudsatser. Materialet som ligger till grund för avhandlingen är texter från äldre och yngre fornsvenska (1225-1526), och huvudsaklThis thesis focuses on the distribution of objects in the history of Swedish. The primary focus of the thesis is the distribution of objects relative to negation, and the secondary focus is varying order of nominal arguments in Old Swedish (1225–1526).In Modern Swedish, objects may precede the negation, often referred to as Object Shift, OS, or precede a subject, often referred to as Long Object S

While urbanization provides many opportunities to those arriving in thriving urban areas, a greater number of residents necessitates the expansion of housing and infrastructure. This is often achieved through densification, which can lead to increased noise, particularly through increased road traffic. A key challenge of promoting healthy urban planning is to understand potential health effects, e

Genetic determinants underlying most human blood groups are now clarified but variation in expression levels remains largely unexplored. By developing a bioinformatics pipeline analyzing GATA1/Chromatin immunoprecipitation followed by sequencing (ChIP-seq) datasets, we identify 193 potential regulatory sites in 33 blood-group genes. As proof-of-concept, we aimed to delineate the low-expressing com

Most definitions of cancer broadly conform to the current NCI definition: "Cancer is a disease in which some of the body's cells grow uncontrollably and spread to other parts of the body." These definitions tend to describe what cancer "looks like" or "does" but do not describe what cancer "is" or "has become." While reflecting past insights, current definitions have not kept pace with the underst

Background: Accurate blood type data are essential for blood bank management, but due to costs, few of 43 blood group systems are routinely determined in Danish blood banks. However, a more comprehensive dataset of blood types is useful in scenarios such as rare blood type allocation. We aimed to investigate the viability and accuracy of predicting blood types by leveraging an existing dataset of

The polyaneuploid cancer cell (PACC) state promotes cancer lethality by contributing to survival in extreme conditions and metastasis. Recent experimental evidence suggests that post-therapy PACC-derived recurrent populations display cross-resistance to classes of therapies with independent mechanisms of action. We hypothesize that this can occur through PACC memory, whereby cancer cells that have

Evolvability is the capacity of a population to generate heritable variation that can be acted upon by natural selection. This ability influences the adaptations and fitness of individual organisms. By viewing this capacity as a trait, evolvability is subject to natural selection and thus plays a critical role in eco-evolutionary dynamics. Understanding this role provides insight into how species

In this didactic paper, we present a theoretical modeling framework, called the G-function, that integrates both the ecology and evolution of cancer to understand oncogenesis. The G-function has been used in evolutionary ecology, but has not been widely applied to problems in cancer. Here, we build the G-function framework from fundamental Darwinian principles and discuss how cancer can be seen th

The high-prevalence blood group antigen, Sda, had been puzzling blood bankers and transfusionists for at least a decade when it was reported in 1967. The characteristic mix of agglutinates and free red blood cells (RBCs), caused by anti-Sda, is seen with the RBCs from 90 percent of individuals of European descent. However, only 2-4 percent of individuals are truly Sd(a-) and may produce anti-Sda.

The timing and connections between global cooling, marine redox conditions, and biotic turnover are underconstrained for the Late Ordovician. The second most severe mass extinction occurred at the end of the Ordovician period, resulting in ~85% loss of marine species between two extinction pulses. As the only “Big 5” extinction that occurred during icehouse conditions, this interval is an importan

Aquatic organisms are constantly at risk of being exposed to potentially harmful chemical compounds of natural or anthropogenic origin. Biological life can for instance respond to chemical stressors by changes in gene expression, and thus, certain gene transcripts can potentially function as biomarkers, i.e. early warnings, of toxicity and chemical stress. A major challenge for biomarker applicati

Cancer cells in solid tumors experience hypoxia, a condition of low O2 concentration, since their O2 demand exceeds the supply from the surrounding vasculature. However, how these cells adapt to hypoxia requires further elucidation. Here, we use a transparent phosphorescent thin film to visualize the self-generated hypoxia field of prostate cancer cells and quantify local O2 consumption rates, mea

Groundwater hydraulics and aquifer processes are largely investigated using techniques that involve some kind of borehole test pumping. Such techniques are well established in the engineering and scientific community but are resource demanding. Time series analysis offer a collection of alternative methods that can be used to evaluate groundwater processes like recharge by using natural groundwate

Recent research has indicated that machining of titanium alloys with uncoated cemented tungsten carbide tools fulfil the criteria for Kirkendall porosity. If this occurs during machining, it could contribute to the type and rate of tool wear, compromising the tools structural integrity close to the edge line within the contact zone. In this study, voids were observed at the tool-workpiece contact

Aims The Trump movement displays several key features of a populist movement with a strong leader and a broad unorganized base of followers opposed to a per-ceived liberal elite establishment. In 2024, Trump gained strong support from strata with low income, low education and Hispanic men, previously not strong support-ers of Republicans. This study investigates the preconditions for a populist mo

Tumor hypoxia plays a critical role in cancer progression and therapeutic resistance. Here, we present a protocol for the self-generation of hypoxia by metastatic cancer cells using phosphorescence-based O2 sensing. We describe steps for phosphorescent film calibration, system assembly, and real-time imaging of hypoxia development. We then detail approaches to spatially map resulting O2 gradients.

Carbon Fibre-Reinforced Polymers (CFRP) are a fast growing market of high performance materials and components. Thermally induced damage during machining processes such as drilling or routing are among the limiting factors for product quality, yet accurate temperature measurement remains challenging. This study develops a methodology which combines machinable thermocouples and IR thermometry techn