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Advanced therapy medicinal products (ATMPs) are complex biological products that present specific scientific and regulatory challenges during clinical development. This thesis aimed to analyse consolidated Part I considerations raised during assessment of investigational ATMP clinical trial applications (CTAs) under the Clinical Trials Regulation (CTR) to identify recurring scientific and regulato
Voluntary carbon markets (VCM) have grown significantly over the past years. However, the VCM is facing a ‘credibility crisis’ due to governance, technical, and market issues. Notably, despite the significant role of credibility in the VCM, a lack of systematic assessment frameworks in this area is discerned. To address this knowledge gap, this thesis set out to build, test, and evaluate a framewo
Objective: This review aims to consolidate contemporary literature examining the impact of physical activity (PA) and exercise on sensitisation and pain perception in individuals with chronic non-specific low back pain (cLBP). Methods: A semi-systematic approach was employed, utilising Pubmed and PEDro databases for the period between 2013-2023. Eligibility criteria included randomised control tri
Sveriges våldsutveckling har väckt debatt om införandet av säkerhetszoner som brottsförebyggande åtgärd. Lagstiftningen trädde i kraft den 25 april 2024 och ger polisen befogenhet att genomföra visitationer och husrannsakan i transportmedel utan att det behövs en konkret brottsmisstanke. Denna studie ämnar att undersöka hur poliser i Malmö, Göteborg och Stockholm resonerar kring vilka fördelar res
Vehicle-to-everything (V2X) is a promising power storage solution for the challenges succeeding the Swedish renewable energy transition. Although, it is a niche innovation facing obstacles such as inadequate infrastructure, uncertainties of battery degradation and a lack of appropriate standards, which hinders its development. This thesis explores the business case for V2X for X Shore’s electric b
Following the increasing number of climatic shocks and disasters, the poor and most vulnerable are disproportionately affected as their already exposed situation becomes further worsened. The gendered impacts of climate disasters have demonstrated how women and girls vulnerable position is exacerbated in relation to existing socio-cultural norms and inequalities, making them one of the most vulner
Biodiversity is today rapidly decreasing, and one of the main threats is land use intensification in forest landscapes. By improving the forest quality in the surrounding landscape of protected areas, the level of biodiversity could increase, and green infrastructure areas have been proposed as a method in Sweden. These areas are called Valuable Forest Areas (VFAs), and contain high densities of s
Volunteers fill an important function in the social work that constantly and in various ways goes on in our society. Without the volunteers' involvement there is a risk that many more people fall between the cracks than actually do, even in the Swedish welfare state. Since volunteers are people whose resources are finite, it is important to gain insight into what motivates, encourages and even
Large-scale restoration projects are being increasingly used to address land degradation and global climate change. While these initiatives are promising, an overemphasis on tree planting may contribute to ecological degradation and carbon loss. This thesis critically examines the AFR100 initiative in southern Africa through literature analysis and expert interviews. By integrating perspectives fr
Den här uppsatsen undersöker den svenska implementeringen av andelsbytesmekanismen för privatpersoner, som återfinns i artikel 8 i Fusions-Direktivet, hädanefter FD. Uppsatsen undersöker även hur Sverige har valt att skydda sin beskattningsrätt när aktieägaren emigrerar till en annan EU MS medan hen äger aktier erhållna via ett andelsbyte. Syftet bakom undersökningen är att utreda huruvida om den This thesis examines the Swedish implementation of the exchange of shares mechanism for individuals, found in article 8 of the Tax Merger Directive, henceforth TMD, and how Sweden has chosen to safeguard its taxation right when the shareholder holding exchanged shares emigrates to another EU MS. The purpose behind this is to examine if the Swedish im-plementation, given the more recent case-law fr
Titel: Flytande aktier, svävande siffror: spelar free float roll? Seminariedatum: 2024-05-30 Kurs: Examensarbete i finansiering (FEKH89), 15 högskolepoäng. Författare: Jeanne Lindestam, Julia Rodén, Anna Wogén Handledare: Maria Gårdängen Nyckelord: Accruals earnings management, free float, den modifierade Jones-modellen, börspsykologi, agentteori, signalteori, earnings smoothing, earnings ag
The European Union implements the Environmental Noise Directive (END), which offers a framework for evaluating and assessing environmental noise. All EU members are required to create strategic noise maps to inform the public about noise pollution and its effects. This study followed these directives and guidelines to collect the required data and employed the NORD2000 model to simulate traffic no
Barn och unga lever i en värld där de riskerar att möta svårigheter som kan påverka deras hälsa och utveckling negativt. Interventioner för att stärka barns motståndskraft behövs för att skydda mot negativa konsekvenser rotade i utmaningar under uppväxten. Traumamedveten omsorg (TMO) är en psykoedukativ intervention, som ges till vuxna i barnets närmiljö. Tidigare forskning har undersökt TMO utifrIn today’s society, children and adolescents face adversities that can impair their mental health and psychological development. Interventions that aim to strengthen children’s resilience are crucial in order to protect children from detrimental outcomes. Trauma-Informed Care (TIC) is a psychoeducational intervention, which is administered to adults in children’s environments. Previous research ha
The Disproportionate Burden-Expense Exception within the EU-U.S. Data Privacy Framework is allowing certified organisations to refuse access requests based on organisational cost or burden. The thesis is examining how this exception affects the ability of EU controllers to fulfil their obligation under Article 15(3) GDPR, when employing a U.S. processor. To answer this question, the thesis is exam
Forskningsfrågor: Hur använder sig Svenska Spel och Betsson AB av CSR och finns det någon skillnad i CSR-arbetet mellan ett privatägt och statligt ägt spelbolag? Leder företagens CSR-arbete till ökad lojalitet bland kunder och ökad legitimitet för företagen? Syfte: Undersöka hur Svenska Spel och Betsson AB använder CSR i sitt arbete, samt om detta bidrar till ökad lojalitet bland kunder och ökad Research questions: How do Svenska Spel and Betsson AB utilize CSR, and is there any difference in CSR practices between privately-owned and state-owned gambling companies? Does the companies' CSR efforts lead to increased customer loyalty and enhanced legitimacy for the companies? Purpose: To investigate how Svenska Spel and Betsson AB utilize CSR, and whether this contributes to increased c
AIMS: To investigate whether out-of-hospital cardiac arrest (OHCA) survivors had lower levels of self-reported physical activity compared to a non-cardiac arrest control group with myocardial infarction (MI), and to explore if symptoms of anxiety, depression, kinesiophobia (fear of movement) and fatigue were associated with a low level of physical activity.METHODS: Predefined case-control sub-studAIMS: To investigate whether out-of-hospital cardiac arrest (OHCA) survivors had lower levels of self-reported physical activity compared to a non-cardiac arrest control group with myocardial infarction (MI), and to explore if symptoms of anxiety, depression, kinesiophobia (fear of movement) and fatigue were associated with a low level of physical activity.METHODS: Predefined case-control sub-stud
Tool wear intensity is one of the major performance and economic indicators of metal cutting processes. Understanding and control of tool wear and its governing mechanisms enables effective and sustainable manufacturing. Known wear mechanisms include abrasive, adhesive, chemical and diffusional, where their individual or combined action leads to an overall tool degradation. In this study, we prese
Two synchrotron-based studies on 4H-pyran-4-thione, photoelectron spectroscopy and vacuum ultraviolet (VUV) absorption spectra were performed. A highly resolved structure was observed in the photoelectron spectrum (PES), in contrast to an earlier PES study, where little structure was observed. The sequence of ionic states was determined using configuration interaction and coupled cluster methods.
