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Protein Engineering Allows for Mild Affinity-based Elution of Therapeutic Antibodies

Presented here is an engineered protein domain, based on Protein A, that displays a calcium-dependent binding to antibodies. This protein, ZCa, is shown to efficiently function as an affinity ligand for mild purification of antibodies through elution with ethylenediaminetetraacetic acid. Antibodies are commonly used tools in the area of biological sciences and as therapeutics, and the most commonl

Serum proteome profiles in patients treated with targeted temperature management after out-of-hospital cardiac arrest

BACKGROUND: Definition of temporal serum proteome profiles after out-of-hospital cardiac arrest may identify biological processes associated with severe hypoxia-ischaemia and reperfusion. It may further explore intervention effects for new mechanistic insights, identify candidate prognostic protein biomarkers and potential therapeutic targets. This pilot study aimed to investigate serum proteome p

Treatment Preferences for Acute Allergic Reactions : A Discrete Choice Experiment

Background: Timely treatment of acute allergic reactions (AARs) is important to minimize reaction severity. Corticosteroid tablets dissolved in water are commonly used in mainstay treatment. A new oral film that dissolves on the tongue provides a faster and less cumbersome alternative to tablets for corticosteroid administration during AARs. This study evaluated patients' preferences for attribute

Redox chemistry of a dimanganese(II,III) complex with an unsymmetric ligand: Water binding, deprotonation and accumulative light-induced oxidation

A dinuclear manganese complex {[(Mn2L)-L-II,IIII(mu-OAc)(2)]-ClO4} has been synthesised, where L is the dianion of 2-{[bis-(pyrid-2-ylmethyl)amino]methyl}-6-{[(3,5-di-tert-butyl-2- hydroxybenzyl)(pyrid-2-ylmethyl)amino]methyl)-4-methylphenol, an unsymmetric binucleating ligand with two coordinating phenol groups. The two manganese ions, with a Mn-Mn distance of 3.498 angstrom, are bridged by the t

Modelling antibody orientation at bacterial surfaces

Varför gör vissa bakterier oss sjuka men inte andra? Hur kommer det sig att vissa bakterier lyckas överleva och infektera särskilda delar av kroppen men väldigt sällan andra? Bakterier och människor har evolverat länge tillsammans och har därmed lyckats utveckla specifika angrepps och försvarsmekanismer mot varandra. Det är känt sedan tidigare att några bakterier uttrycker proteiner med förmågan Bacteria and humans have co-evolved since their common existence. They have thereby developed very specific defence and target mechanisms against one another. Understanding the complex biomolecular processes behind these interactions can be of great use for developing treatments against bacterial diseases. The aim of this thesis project was to verify, and introduce a model for understanding, the i

The molecular basis of human igg-mediated enhancement of C4b-binding protein recruitment to group a streptococcus

Streptococcus pyogenes infects over 700 million people worldwide annually. Immune evasion strategies employed by the bacteria include binding of the complement inhibitors, C4b-binding protein (C4BP) and Factor H in a human-specific manner. We recently showed that human IgG increased C4BP binding to the bacterial surface, which promoted streptococcal immune evasion and increased mortality in mice.

LUSEM alumni amongst Swedish summer radio hosts

On 10 July and 19 July, two LUSEMs alumni are featured on the radio show Sommar i P1, a popular programme broadcasted by the Swedish public service radio. Sommar i P1 is a popular programme broadcasted by the Swedish public service radio. It features a range of storytellers and each host create their own 1.5 hour-long show – choosing their own music and what to talk about. Being a host on Sommar i

https://www.lusem.lu.se/article/lusem-alumni-amongst-swedish-summer-radio-hosts - 2025-10-23

Platser kvar på utbildning

Arbetar du med att planera och följa upp din verksamhet? Då är detta utbildningen för dig! Det finns platser kvar på utbildningen Ekonomiskt planera och följa upp verksamheten. Utbildningen består av tre delar: Första tillfället: 11 oktober (förmiddag) Andra tillfället: 18 oktober (förmiddag) Ekonomispelet: Datum meddelas senare Passa på att anmäla dig nu innan 9 oktober klockan 10:00 för att kunn

https://www.ekonomiwebben.lu.se/artikel/platser-kvar-pa-utbildning-1 - 2025-10-23

SEMINAR: Breaking Multilingual Silence in the Nordic Performing Arts

5 december 2025 09:30 till 17:00 | Teater SEMINAR: Friday, 5 December 2025, at 9:30–17:00Led by Dr. Vanja Hamidi Isacson (SE) and Director David Kozma (FI), coordinated by Post Theatre Collective (FI).Throughout the Nordic region, multilingualism is an integral part of daily life for many people. The use of multiple languages in everyday interactions is not only common but often essential. However

https://www.konstnarliga.lu.se/evenemang/seminar-breaking-multilingual-silence-nordic-performing-arts - 2025-10-23

Untitled

Untitled Master’s Dissertation Structural Mechanics JUAN CARDENAL BASTÉ Report TV SM -5150 JU A N C A RD EN A L BA STÉ D ESIG N M ETH O D FO R STR U T-B EA M C O N N EC TIO N IN H IN G ED FR A M ES DESIGN METHOD FOR STRUT-BEAM CONNECTION IN HINGED FRAMES Detta är en tom sida! Copyright © 2012 by Structural Mechanics, LTH, Sweden. Printed by Media-Tryck LU, Lund, Sweden, July, 2012 (Pl). For inform

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5150.pdf - 2025-10-23

The Stobaeus Project

Museum Stobaeanum Explore the collections of Museum Stobaeanum – the first public museum in Lund, established in the early 18th century, with roots in the cabinet of curiosities of Kilian Stobaeus (1690–1742), professor in natural philosophy and history at Lund University. Who was Kilian Stobaeus? He was a physician, a scientist, and a university vice-chancellor. Kilian Stobaeus was the man whose

https://www.historiskamuseet.lu.se/stobaeus - 2025-10-23